Certain Aspects of Drug Distribution to Brain

  • William H. Oldendorf
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 69)


The wall of the general capillary (tissues other than brain) is freely permeable to all small molecules but the brain capillary wall, the blood-brain barrier (BBB), is impermeable to many small molecules but permeable to certain others. The fundamental difference between these quite different capillary permeability characteristics is diagrammed in Fig. 1. In general capillaries, blood plasma solutes exchange with the more stationary pericapillary extracellular fluid (ECF) largely by diffusion through clefts between the cells making up the capillary wall. This exchange is, accordingly, via extracellular pathways.


Capillary Wall Brain Uptake Relative Affinity Tritiated Water Capillary Cell 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • William H. Oldendorf
    • 1
    • 2
  1. 1.Veterans AdministrationBrentwood HospitalLos AngelesUSA
  2. 2.UCLA School of MedicineLos AngelesUSA

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