Cerebral Permeability Phenomena in Epilepsy

  • Leontino Battistin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 69)


In recent years cerebral permeability has become of increasing interest in neurosciences, and the structural and functional complexity of the brain barriers has been the object of various studies15. It is becoming increasingly clear that the movements of metabolites into and out of brain cells occur through active processes of uptake, exit, and exchange; these processes are likely to play an important role in the control of cerebral metabolite levels, and therefore in the control of cerebral metabolism and functionl14, 20, 4, 15.


Amino Acid Uptake Subcortical Area Rabbit Brain Generalize Convulsion Epileptogenic Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bakay, L., Alterations of the brain barrier system in pathological states. In A. Lajtha (Ed.), Handbook of Neurochemistry, Vol.VII, Plenum, New York, 1972, pp.417–427.CrossRefGoogle Scholar
  2. 2.
    Battistin, L., Grynbaum, A., and Lajtha, A., Energy dependence of amino acid uptake in brain slices. Brain Research, 16 (1969) 187–197.CrossRefPubMedGoogle Scholar
  3. 3.
    Battistin, L., Grynbaum, A., and Lajtha, A., Distribution and uptake of amino acids in various regions of the cat brain in vitro, J.Neurochem., 16 (1969) 1459–1468.CrossRefPubMedGoogle Scholar
  4. 4.
    Battistin, L., and Lajtha, A., Regional distribution and movement of amino acid in the brain, J.neurol.Sei. (Amst.), 10 (1970) 313–322.CrossRefGoogle Scholar
  5. 5.
    Battistin, L., Grynbaum, A., and Lajtha, A., The uptake of various amino acids by the mouse brain in vivo. Brain Research, 29 (1971) 85–99.CrossRefPubMedGoogle Scholar
  6. 6.
    Battistin, L., Varotto, M., Zanchin, G., Trevisan, C., De Lorenzi, A., Cerebral amino acid uptake in vitro after drug-induced convulsions. 5th International Meeting of the I.S.N., Barcelona, September 1975. pp.447 (abstract).Google Scholar
  7. 7.
    Battistin, L., Varotto, M., and De Lorenzi, A., Amino acid uptake in vivo by the mouse brain after drug-induced convulsions. Brain Research, 89 (1975) 215–224.CrossRefPubMedGoogle Scholar
  8. 8.
    Berl, S., Takagaki, G., and Purpura, D.P., Metabolic and pharmacological effects of injected amino acids and ammonia on cortical epileptogenic lesions, J.Neurochem., 7 (1961) 198–209.CrossRefGoogle Scholar
  9. 9.
    Cohen, S.R., The estimation of extracellular space of brain tissue in vitro. In N. Marks and R. Rodnight (Eds.), Research Methods in Neurochemistry, Vol.1, Plenum Press, New York, 1972, pp.179–219.CrossRefGoogle Scholar
  10. 10.
    Cohen, S.R., Blasberg, R., Levi, G., and Lajtha, A., Compart- mentation of the inulin space in mouse brain slices, J.Neurochem., 15 (1968) 707–720.CrossRefPubMedGoogle Scholar
  11. 11.
    Cutler, R.W.P., Lorenzo, A.V., and Barlow, C.F., Changes in blood- brain permeability during pharmacologically induced convulsions, In A. Lajtha and D.H. Ford (Eds.), Brain Barrier System, Progress in Brain Research, Vol.29, Elsevier, Amsterdam, 1968, pp.367–378.CrossRefGoogle Scholar
  12. 12.
    Guidotti, A., Badiani, G., and Pepeu, G., Taurine distribution in cat brain, J.Neurochem., 19 (1972) pp.431–435.CrossRefPubMedGoogle Scholar
  13. 13.
    Kandera, J., Levi, G., and Lajtha, A., Control of cerebral metabolites levels. II. Amino acid uptake and levels in various areas of the rat brain, Arch.Biochem, 126 (1968)249–260.CrossRefPubMedGoogle Scholar
  14. 14.
    Lajtha, A., Transport as control mechanism of cerebral metabolite levels. In A. Lajtha and D.H. Ford (Eds.), Brain Barrier Systems, Progress in Brain Research, Vol.29, Elsevier, Amsterdam, 1968, pp.201–218.CrossRefGoogle Scholar
  15. 15.
    Lee, J.C., Evolution in the concept of the blood-brain barrier phenomenon. In H.M. Zimmerman (Ed.), Progress in Neuropathology, Grune and Stratton, New York, 1971, pp.84–145.Google Scholar
  16. 16.
    Levi, G., Kandera, J., Lajtha, A., Control of cerebral metabolite levels. I. Amino acid uptake and levels in various species, Arch. Biochem., 119 (1967) 303–311.CrossRefPubMedGoogle Scholar
  17. 17.
    Levin, E., Wolosiuk, R., Scilli, G., and Glanczepigel, R., In vitro incubation of brain hemispheres. Fluid spaces and amino acid uptake, Neurol. (Minneapolis) 20 (1970) 584–593.CrossRefGoogle Scholar
  18. 18.
    Lorenzo, A.V., Shirahige, J., Liang, M., and Barlow, C.F., Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures, Amer.J.Physiol., 223 (1972) 268–277.CrossRefPubMedGoogle Scholar
  19. 19.
    Lovell, R.A., Some neurochemical aspects of convulsions, In A. Lajtha (Ed.), Handbook of Neurochemistry, Vol.6, Plenum Press, New York, 1971, 63–102.Google Scholar
  20. 20.
    Neame, K.D., Transport, metabolism, and pharmacology of amino acids in brain. In A.N. Davison and J. Dobbing (Eds.), Applied Neurochemistry, Blackwell, Oxford, 1968, pp.119–177.Google Scholar
  21. 21.
    Oja, S.S., and Lahdesmaki, P., Is taurine an inhibitory neurotransmitter? Med. Biol. 52 (1974) 138–143.PubMedGoogle Scholar
  22. 22.
    Perry, T.L., Sanders, H.D., Hansen, S., Lesk, D., Kloster, M., and Gravlin, L., Free amino acids and related compounds in five regions of biopsied cat brain, J.Neurochem., 19 (1972) 2651–2656.CrossRefPubMedGoogle Scholar
  23. 23.
    Purpura, D.P., Girado, M., Smith, T.G., Gomez, J.A., Synaptic effects of systemic aminobutyric acid in cortical regions of increased vascular permeability, Proc.Soc.Exp.Biol.Med., 97 (1958) 348–353.CrossRefPubMedGoogle Scholar
  24. 24.
    Van Gelder, N.M., and Courtois, A., Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy, Brain Research, 43 (1972) 477–484.CrossRefPubMedGoogle Scholar
  25. 25.
    Van Gelder, N.M., Antagonism by taurine of cobalt induced epilepsy in cat and mouse. Brain Research, 47 (1972) 157–165.CrossRefPubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Leontino Battistin
    • 1
  1. 1.Clinica delle Malattie Nervose e MentaliUniversita di PadovaPadovaItaly

Personalised recommendations