Transport of Dopamine in Discrete Areas of the Striatum and of Cerebral Cortex in the Rat
For many years, the catecholaminergic innervation of the cerebral cortex in the rat was assumed to be only represented by the arborisations of the dorsal noradrenergic pathway. However, a quantity of dopamine (DA) slightly higher than that expected if DA was only the precursor of noradrenaline (NA) was found in this structure. It was thus postulated that the relatively high content of DA was related to the presence of dopaminergic terminals26. Two complementary approaches were available to test this hypothesis. The first one consisted of detecting some properties of dopaminergic terminals following the selective destruction of the noradrenergic ascending pathway. The second was to simultaneously identify specific properties of each type of catecholaminergic terminal in the cerebral cortex of normal rats. Since DA and NA are taken up in dopaminergic and noradrenergic terminals respectively by specific uptake processes, the estimation of the uptake of these amines could be used in these studies as an index of the specific properties of each type of catecholaminergic terminal.
KeywordsCerebral Cortex Brain Research Electrolytical Lesion Dopaminergic Innervation Dopaminergic Terminal
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