Characteristics of the Uptake and Release of Glutamic Acid in Synaptosomes from Rat Cerebral Cortex. Effects of Ouabain

  • G. Takagaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 69)


It is often described that glutamic acid seems probably to be a major excitatory transmitter in the mammalian CNS. Glutamic acid is very rapidly taken up from the medium into mammalian cerebral slices and synaptosomes. And it is released from either of them on depolarization effected by electrical pulses and elevated medium potassium. These properties of glutamic acid have been studied extensively and discussed in relation to its possible physiological transmitter role in CNS, although the in vitro techniques certainly involve highly unphysiological conditions 4, 8, 9.


Glutamic Acid Glutamate Transport Amino Acid Fraction High Affinity Uptake System Cerebral Slice 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • G. Takagaki
    • 1
  1. 1.Department of NeurochemistryTokyo Metropolitan Institute for NeurosciencesFuchu-shi, TokyoJapan

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