Kinins and Anti-Inflammatory Drugs

  • H. O. J. Collier
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

In 1959, we showed that bradykinin elicits bronchoconstriction in the guinea-pig and that a small dose of aspirin or phenylbutazone abolishes this response to bradykinin, without diminishing the bronchoconstrictor effect of histamine or 5-hydroxytryptamine (1, 2). Several of the properties of this antagonism suggested that it occurred at bradykinin receptors on the smooth muscle (3,4; but when bronchoconstriction induced by the Hounslow preparation of slow-reacting substance in anaphylaxis (SRS-A-H), which acted at different receptors, also proved to be blocked by antiphlogistic acids (5) and when several other paradoxical features of the antagonism emerged, we proposed that aspirin exerted its effect at a point on the route leading to or from the specific receptors (5,6) and later suggested that this might involve the release of an intermediary substance (7). Piper and Vane (8) have now shown that such a mechanism exists in guinea-pig isolated lungs, in that antiphlogistic acids block the release of rabbit-aorta contracting substance. The background and implications of this story are outlined here, with particular reference to kinins. A brief discussion of its bearing on the mode of action of aspirin has already appeared (9).

Keywords

Peritoneal Exudation Antinociceptive Action Potency Ratio Bradykinin Receptor Collier Table 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. (1).
    COLLIER, H.O.J., HOLGATE, J.A., SCHACHTER, M. & SHORLEY, P.G. J.Physiol.Lond., 149, 54P (1959).Google Scholar
  2. (2).
    COLLIER, H.O.J., HOLGATE, J.A., SCHACHTER, M. & SHORLEY, P.G. Br.J.Pharmac.Chemother., 15, 290 (1960).Google Scholar
  3. (3).
    COLLIER, H.O.J. & SHORLEY, P.G. Br.J.Pharmac.Chemother., 15, 601 (1960).Google Scholar
  4. (4).
    COLLIER, H.O.J. Biochem.Pharrnac, 10, 47 (1962).CrossRefGoogle Scholar
  5. (5).
    BERRY, P.A. & COLLIER, H.O.J. Br.J.Pharmac.Chemother., 23, 201 (1964).Google Scholar
  6. (6).
    COLLIER, H.O.J., JAMES, G.W.L. & SCHNEIDER, C. Nature, Lond., 212, 411 (1966).CrossRefGoogle Scholar
  7. (7).
    COLLIER, H.O.J. In Advances in Pharmacology and Chemotherapy, Academic Press, New York. In press (1969).Google Scholar
  8. (8).
    PIPER, P.J. & VANE, J.R. Nature, Lond., 223, 29 (1969).CrossRefGoogle Scholar
  9. (9).
    COLLIER, H.O.J. Nature, Lond., 223, 35 (1969).CrossRefGoogle Scholar
  10. (10).
    STERN, P. & BAšAGIć, E. Lancet, ii, 870 (1968).CrossRefGoogle Scholar
  11. (11).
    GUZMAN, F., BRAUN, C., LIM, R.K.S., POTTER, G.D. & RODGERS, D.W. Archs.int.Pharmacodyn.Ther., 149, 571 (1964).Google Scholar
  12. (12).
    GJURIS, V., HEICKE, B. & WESTERMANN, E. Arch.exp.Path.Pharmak., 248, 540 (1964).CrossRefGoogle Scholar
  13. (13).
    DEFFENU, G., PEGRASSI, L. & LUMACHI, B. J.Pharm.Pharmac., 18, 135 (1966).CrossRefGoogle Scholar
  14. (14).
    EMELE, J.F. & SHANAMAN, J. Proc.Soc.exp.Biol.Med., 114, 680 (1963).PubMedGoogle Scholar
  15. (15).
    COLLIER, H.O.J., DINNEEN, L.C., JOHNSON, C.A. & SCHNEIDER, C. Br.J.Pharmac.Chemother., 32, 295 (1968).Google Scholar
  16. (16).
    LIM, R.K.S., MILLER, D.G., GUZMAN, F., RODGERS, D.W., ROGERS, R.W., WANG, S.K., CHAO, P.Y. & SHIH, T.Y. Clin.Pharmac.Ther., 8, 521 (1967).Google Scholar
  17. (17).
    NORTHOVER, B.J. & SUBRAMANIAN, B. Br.J.Pharmac.Chemother., 17, 107 (1961).Google Scholar
  18. (18).
    VARGAFTIG, B.B. Experientia, 22, 182 (1966).PubMedCrossRefGoogle Scholar
  19. (19).
    COLLIER, H.O.J., DINNEEN, L.C., PERKINS, A.C. & PIPER, P.J. Arch.exp.Path.Pharmak., 259., 159 (1968).Google Scholar
  20. (20).
    BERRY, P.A. Slow-reacting Substance in Anaphylaxis (SRS-A): its Release, Actions and Antagonism. Thesis for Ph.D. p. 91 London: Council for National Academic Awards (1966).Google Scholar
  21. (21).
    BHOOLA, K.D., COLLIER, H.O.J., SCHACHTER, M. & SHORLEY, P.G. Br.J.Pharmac.Chemother., 19, 190 (1962).Google Scholar
  22. (22).
    VARGAFTIG, B.B., DE MIRANDA, E.P. & LACOUME, B. Nature, Lond., 222, 883 (1969).CrossRefGoogle Scholar
  23. (23).
    COLLIER, H.O.J. & SHORLEY, P.G. Br.J.Pharmac.Chemother., 20, 345 (1963).Google Scholar
  24. (24).
    COLLIER, H.O.J. & JAMES, G.W.L. Br.J.Pharmac.Chemother., 30, 283 (1967).Google Scholar
  25. (25).
    COLLIER, H.O.J., JAMES, G.W.L. & PIPER, P.J. Br.J.Pharmac. Chemother., 34, 76 (1968).Google Scholar
  26. (26).
    GREEFF, K. & MOOG, E. Arch.exp.Path.Pharmak., 248, 204 (1964).Google Scholar
  27. (27).
    JAQUES, R. Helv.physiol.Acta, 23, 156 (1965).Google Scholar
  28. (28).
    LIM, R.K.S., GUZMAN, F., RODGERS, D.W., GOTO, K., BRAUN, C., DICKERSON, C.D. & ENGLE, R.J. Archs. int.Pha rmacodyn.Ther., 152., 25 (1964).Google Scholar
  29. (29).
    COLLIER, H.O.J. & LEE, I.R. Br.J.Pharmac.Chemother., 21, 155 (1963).Google Scholar
  30. (30).
    LEWIS, G.P. In Salicylates: an International Symposium, ed. Dixon, A.St.J., Martin, B.K., Smith, M.J.H. & Wood, P.H.N., p. 134. London: Churchill (1963).Google Scholar
  31. (31).
    COLLIER, H.O.J., HAMMOND, A.R. & WHITELEY, B. Nature, Lond., 200, 176 (1963).CrossRefGoogle Scholar
  32. (32).
    NIEMEGEERS, C.J.E., VERBRUGGEN, F.J. & JANSSEN, P.A.J. J.Pharm. Pharmac., 16, 810 (1964).CrossRefGoogle Scholar
  33. (33).
    SEED, J.C. Clin.Pharmac.Ther., 6, 354 (1965).Google Scholar
  34. (34).
    WHITTLE, B.A. Br.J.Pharmac.Chemother., 22, 246 (1964).Google Scholar
  35. (35).
    HENDERSHOT, L.C. & FORSAITH, J. J.Pharmac.exp.Ther., 125, 237 (1959).Google Scholar
  36. (36).
    ADAMS, S.S. & COBB, R. In Salicylates:an International Symposium, ed. Dixon, A.St.J., Martin, B.K., Smith, M.J.H. & Wood, P.H.N. p. 127. London: Churchill (1963).Google Scholar
  37. (37).
    O’BRIEN, J.R. Lancet, i, 779 (1968).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • H. O. J. Collier
    • 1
  1. 1.Parke-Davis & Co.Hounslow, MiddlesexEngland

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