I.C.I. 73602 — A Potent Anti-Rhinovirus Compound
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Guanidine has been known for a long time as a selective inhibitor of replication of small RNA viruses in tissue culture.1 The biochemical basis for this activity was traced to an inhibition of the synthesis of viral RNA polymerase,2 and thus was specific for viral replication, leaving cellular replication and function unaffected. The antiviral activity of guanidine cannot however be demonstrated in vivo, consequently much work has been carried out to try to find useful antiviral activity in derivatives of guanidine.