Postmenopausal Parkinsonism: Brain Iron Overload?

  • Charles N. Still
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 90)


Records of 11 postmenopausal parkinsonism patients were evaluated in comparison with those of 11 postmenopausal depression patients. None had a history of encephalitis, stroke, drug-induced or toxic extrapyramidal disorders, or active bleeding within six months before admission. There was no significant differences between the two groups with regard to time interval from menopause to onset of symptoms, height, weight, or age at first admission. Both groups showed normal height, hemoglobin, hematocrit, and erythrocyte counts. Parkinsonism patients were underweight and had a shorter interval from menopause to onset of symptoms (12.4 ± 1.9 vs. 16.8 ± 2.5 yr.). These findings are compatible with the hypothesis that in parkinsonism, hereditary pre disposition to positive body iron balance may be associated with alteration of the blood-brain barrier in parkinsonism.


Iron Deficiency Anemia Erythrocyte Count Ventrolateral Nucleus Urinary Iron Excretion Single Etiology 
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  1. Barbeau, A. and Boileau, J.L. (1969). Mobilizable iron in Parkin son’s disease. Neurology 19 ,314.Google Scholar
  2. Dantzler, M.U. (1972). Final Comprehensive Report. Comprehensive Nutritional Health Survey. p. 6. State Board of Health, Columbia, South Carolina.Google Scholar
  3. Diem, K. and Lentner, C. (1970). Scientific Tables. Seventh Edition. p. 711, Geigy Pharmaceuticals, Ardsley, New York.Google Scholar
  4. Earle, K.M. (1968). Studies on Parkinson’s disease including X-ray fluorescent spectroscopy of formalin fixed brain tissue. J. Neuropath. Exp. Neurol. 27 ,1–14.CrossRefPubMedGoogle Scholar
  5. Elwood, P.C. (1971). Epidemiological aspects of iron deficiency in the elderly. Gerontol. Clin. 13 ,2–11.CrossRefGoogle Scholar
  6. Elwood, P.C., Rees, G., and Thomas, J.D.R. (1968). Community study of menstrual iron loss and its association with iron deficiency anemia. In the Brit. J. Prev. Soo. Med. 22 ,127–131.Google Scholar
  7. Gowers, W.R. (1888). A Manual of Diseases of the Nervous System. Volume 2, p. 588, Churchill, London.Google Scholar
  8. Green, D.E. and Golberger, R.F. (1967). Molecular Insights into the Living Process, pp. 183–212, Academic Press, New York.Google Scholar
  9. Greenfield, J.G. (1955). The Pathology of Parkinson’s Disease. In James Parkinson (1755–1824) ,(Critchley, M., Ed.) pp. 219–243. Macmillan, London.Google Scholar
  10. Hallgren, B. and Sourander, P. (1958). The effect of age on the non-haemin iron in the human brain. J. Neuroohem. 3 ,41–51.CrossRefGoogle Scholar
  11. Kondo, K. Kurland, L.T. and Schull, W.J. (1973). Parkinson’s disease: genetic analysis and evidence of a multifactorial etiology. Mayo Clin. Proceedings 48 ,465–475.Google Scholar
  12. Kurland, L.T., Hauser, W.A., Okazaki, H., and Nobrega, F.T. (1969). Epidemiologic studies of parkinsonism with special reference to the cohort hypothesis. In Third Symposium of Parkinson’s Disease ,pp. 12–16, Livingstone, Edinburgh.Google Scholar
  13. Oldendorf, W.H., Cornford, M., and Brown, W.J. (1976). The large apparent metabolic work capacity of the blood-brain barrier. Arch. Neurol. (Chicago) 33 ,390.Google Scholar
  14. Parkinson, J. (1817). An Essay on the Shaking Palsy. pp. 1–66. Sherwood, Neely, and Jones, London.Google Scholar
  15. Poskanzer, D.C. and Schwab, R.S. (1963). Cohort analysis of Parkinson’s syndrome: evidence for a single etiology related to subclinical infection about 1920. J. Chron. Bis. 16 ,961–973.CrossRefGoogle Scholar
  16. Rojas, G., Asenjo, A., Chiorino, R., Aranda, L., Rocamora, R. and Donoso, P. (1965). Cellular and subcellular structure of the ventrolateral nucleus of the thalamus in Parkinson disease. Deposits of iron. Confin. Neurol. 26 ,362–376.CrossRefPubMedGoogle Scholar
  17. Still, C.N. (1974). Blood, bread, iron and the aging brain. J. South Carolina Med. Assoc. 70 ,279–284.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Charles N. Still
    • 1
  1. 1.William S. Hall Psychiatric Institute, and the Department of Neuropsychiatry and Behavioral ScienceThe University of South Carolina School of MedicineColumbiaUSA

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