The Parkinsonian Syndrome and its Dopamine Correlates

  • Margaret M. Hoehn
  • Thomas J. Crowley
  • Charles O. Rutledge
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 90)


The urinary excretion of free dopamine in 37 untreated parkinsonian patients correlated negatively with the severity of rigidity and akinesia (p<0.025) and with total neurologic deficit (p<0.05). In a parallel study of psychiatric patients, those with the lowest levels of urinary free dopamine before treatment were the most vul nerable to, and developed the most severe, secondary parkinsonian rigidity (p<0.005), akinesia (p<0.05), and total deficit (p<0.01) when they were subsequently treated for two weeks with trifluoperazine. In neither study was there a significant correlation between free urinary dopamine and tremor.

These studies directly associate the level of free dopamine in the urine with the severity of the parkinsonian syndrome. Therefore, although many peripheral sources contribute to urinary free dopamine, a small decrease in the level may actually reflect the severity of the disturbance of central dopamine metabolism and the known deficiency of dopamine in the neurons of the parkinsonian brain.


Psychiatric Patient Parkinsonian Patient Neurologic Deficit Score Extrapyramidal Sign Parkinsonian Sign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Margaret M. Hoehn
    • 1
  • Thomas J. Crowley
    • 2
  • Charles O. Rutledge
    • 3
  1. 1.Departments of NeurologyUniversity of Colorado Medical CenterDenverUSA
  2. 2.Departments of PsychiatryUniversity of Colorado Medical CenterDenverUSA
  3. 3.Department of Pharmacology and ToxicologyUniversity of Kansas School of PharmacyLawrenceUSA

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