Abstract
Among many side-effects following (L-3,4-dihydroxyphenylalanine) treatment short-lasting aphrodisiac action has in some cases been found in male and female parkinsonian patients (Hyyppä et al. 1970, Calne and Sandler 1970, Jenkins and Groh 1970). Whether this phenomenon is directly due to the action of L-dopa treatment has not been confirmed exactly. However, plenty of neuroendocrino-logic data about the role of dopamine (DA), as well as of other monoamines in the hypothalamic regulatory function of gonadotrophic hormones (Fuxe and Hökfelt 1969, McCann 1970) make possible to understand the action of L-dopa on the sexual functions. Firstly, L-dopa might increase the content of DA in the regions which are important in mediating sexual behaviour and/or gonadotrophin secretion. Secondly, L-dopa treatment might act through the metabolism of other monoamines in those brain regions.
Supported by grants from the Sigrid Jusélius Foundation and the National Research Council for Medical Sciences, Finland.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ahlenius, S., Eriksson, H., Larsson, K., Modigh, K. and Södersten, P. (1971): Psychopharmacologia (Berl.)20, 383.
Antön-Tay, F., Chou, C., Anton, S. and Wurtman, R. J. (1968): Science162, 277.
Bartholini, G. and Pletscher, A. (1968): J. Pharmacol. exp. Ther.161, 14.
Bartholini, G., DaPrada, M.and Pletscher, A. (1968): J. Pharm. Pharmacol.20, 228.
Brown, P. S. (1971): Neuroendocrinology7, 183.
Butcher, L. L. and Engel, J. (1969): Brain Res.15, 233.
Calne, D. B. and Sandler, M. (1970): Nature (Lond.)226, 21.
Carlsson, A. (1964): Acta neuroveg. (Wien)26, 484.
Chang, C. C. (1964): Int. J. Neuropharmacol, 3, 643.
Curzon, G. and Green, A. R. (1970): Brit. J. Pharmacol.39, 653.
Dörner, G. and Staudt, J. (1969): Neuroendocrinology5, 103.
Fraschini, F., Collu, R. and Martini, L. (1971): In: The Pineal Gland. Ciba Foundation Symposium. Churchill-Livingstone, London, p. 259.
Fuxe, K. and Hökfelt, T. (1969): In: Frontiers in Neuroendocrinology. Ed. by W. F. Ganong and L. Martini. Oxford LTniv. Press, New York. p. 47.
Hornykiewicz, O. (1966): Pharmacol. Rev.18, 925.
Hyyppä, M., Rinne, U. K. and Sonninen, V. (1970): Acta neurol, scand.46, Suppl. 43, 223.
Jenkins, R. B. and Groh, R. H. (1970): Lancet II, 177.
Kambeei, I. A., Mical, R. S. and Porter, J. C. (1970): Endocrinology87, 1.
Kordon, C. (1969): Neuroendocrinology4, 129.
Larsson, K. (1966): Physiol. Behav.1, 255.
Maickel, R. P., Cox, R. H. Jr., Saillant J. and Miller, F. P. (1968): Int. J. Neuropharmacol.7, 275.
McCann, S. M. (1970): Fed. Proc.29, 1888.
Meyerson, B. J. (1964): Acta physiol. scand.63, Suppl. 241.
Orthner, H. (1968): In: Die Sexualität des Menschen. Handbuch der medizinischen Sexualforschung. Ed. by H. Giese. Ferdinand Enke, Stuttgart, p. 446.
O’Steen, W. K. (1965): Endocrinology77, 937.
Rajaniemi, H. and Niemi, M.(1971): (In preparation).
Rinne, U. K., Sonninen, V. and Hyyppä, M. (1971): Life Sci.10, 549.
Szentágothai, J., Flerkö, B., Mess, B. and Halász, B. (1968): Hypothalamic Control of the Anterior Pituitary. Akadémiai Kiadó, Budapest.
Tagliamonte, A., Tagliamonte, P., Gessa, G. L. and Brodie, B. B. (1969): Science166, 1433.
Van Rossum, J., Wijffels, C. and Rijntjes, N.(1969): Europ.J. Pharmacol.7, 337.
Whalen, R. E. and Luttge, W. G. (1970): Science169, 1000.
Wurtman, R. J., Chou, C. and Rose, C. (1970): J. Pharmacol, exp. Ther.174, 351. 304
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Akadémiai Kiadó, Budapest, Hungary
About this chapter
Cite this chapter
Hyyppä, M., Lehtinen, P., Rinne, U.K. (1973). L-Dopa: Its Action on Sexual Behaviour and Brain Monoamines of the Rat. In: Lissák, K. (eds) Hormones and Brain Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2007-4_32
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2007-4_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2009-8
Online ISBN: 978-1-4684-2007-4
eBook Packages: Springer Book Archive