The Role of Sex Hormones in the Metabolism of Drugs and Other Foreign Compounds by Hepatic Microsomal Enzymes

  • T. E. Gram
  • J. R. Gillette


It has long been recognized that there is a sex difference in the duration of action of many drugs administered to intact animals. For example, after the administration of certain barbiturates to male and female rats, females sleep considerably longer than do males (1,2,3). A sex difference in the duration of hypnosis (sleeping time) has also been reported for certain strains of mice but, in contrast to rats, males sleep longer than do females (4,5). Examples of such sex differences in other animal species are rare.


Drug Metabolism Liver Microsome Microsomal Enzyme Gonadal Hormone Hepatic Microsome 
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Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • T. E. Gram
    • 1
  • J. R. Gillette
    • 1
  1. 1.Laboratory of Chemical Pharmacology, National Heart InstituteNational Institutes of HealthBethesdaUSA

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