• Stanford Wessler
  • E. Thye Yin


The concept that altered coagulation of the blood plays a role in thrombosis has a respectable lineage. Richard Wiseman was perhaps the first to apply the newly acquired knowledge of the circulation to the etiology of intravascular coagulation. In 1676, Wiseman described the properties of a thrombus and stated that intravascular coagulation was related, in part, to systemic alterations in the circulating blood (1). This concept, however, was destined to dominate neither the investigation of Wiseman’s day, nor of subsequent generations. Although Virchow almost 200 years after Wiseman mentioned hypercoagulability almost, as it were, in passing (2), data in support of the concept were not forthcoming.


Clotting Factor Prothrombin Activator Blood Clotting Factor Vein Segment Bovine Plasma 
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Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • Stanford Wessler
    • 1
    • 2
  • E. Thye Yin
    • 1
    • 2
  1. 1.Department of MedicineThe Jewish Hospital of St. LouisSt. LouisUSA
  2. 2.Department of MedicineThe Washington University School of MedicineSt. LouisUSA

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