Advertisement

Effects of Estrogens and Progesterones on Collagen Metabolism

  • Stephen M. Krane

Abstract

In attempting to evaluate effects of estrogens and progestational compounds on bone, it is important to consider how the components of the organic matrix may be affected. Bone consists of an inorganic mineral phase, which comprises approximately two thirds of the weight of the tissue, and an organic phase which is largely the protein collagen. Today I shall discuss selected studies on the effects of estrogens and progesterones on metabolism of collagen not only in bone but in other connective tissues as well. It is necessary, however, to review briefly some aspects of the chemistry and biology of collagen (1,2) in order to evaluate the results of such studies.

Keywords

Collagen Synthesis Bone Collagen Collagen Metabolism Label Amino Acid Soluble Collagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ramachandran, G.N. and Gould, B.S. (Eds.) A Treatise on Collagen. Academic Press, London and New York, 1968. Vol. 1, 2A and 2B.Google Scholar
  2. 2.
    Seifter, S. and Gallop, P.M.: The structure proteins, in The Proteins, H. Neurath (Ed.). Academic Press, New York, 1966, pp. 153–458.Google Scholar
  3. 3.
    Piez, K.A.: Cross-linking of collagen and elastin. Ann. Rev. Biochem. 37:547–570, 1968.PubMedCrossRefGoogle Scholar
  4. 4.
    Gross, J.: Studies on the formation of collagen.II. The influence of growth rate on neutral salt extracts of guinea pig dermis. J. Exp. Med. 107:265–277, 1958.PubMedCrossRefGoogle Scholar
  5. 5.
    Tanzer, M.L.: Experimental lathyrism. Int. Rev. Connective Tissue Res. 3:91–112, 1965.Google Scholar
  6. 6.
    Nimni, M.E. and Bavetta, L.A.: Collagen defect induced by penicillamine. Science 150:905–907, 1965.PubMedCrossRefGoogle Scholar
  7. 7.
    Nimni, M.E.: A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. I. Metabolic and functional abnormalities in soft tissues. J. Biol. Chem. 243: 1457–1466, 1968.PubMedGoogle Scholar
  8. 8.
    Harris, E.D., Jr. and Sjoerdsma, A.: Effect of penicillamine on human collagen and its possible application to treatment of scleroderma. Lancet 2:996–999, 1966.PubMedCrossRefGoogle Scholar
  9. 9.
    Smith, Q.T. and Allison, D.J.: Changes of collagen content in skin, femur and uterus of 17 ß-estradiol benzoate-treated rats. Endocrinol. 79:486–492, 1966.CrossRefGoogle Scholar
  10. 10.
    Kao, K.-Y.T., Hitt, W.E. and McGavack, T.H.: Connective tissue XIII. Effect of estradiol benzoate upon collagen synthesis by sponge biopsy connective tissue. Proc. Soc. Exp. Biol. Med. 119:364–367, 1965.PubMedGoogle Scholar
  11. 11.
    Henneman, D.H.: Effect of estrogen on in vivo and in vitro collagen biosynthesis and maturation in young and old female guinea pigs. Endocrinol. 83:678–690, 1968.CrossRefGoogle Scholar
  12. 12.
    Young, M.M., Jasani, C., Smith, D.A. and Nordin, B.E.C.: Some effects of ethinyl oestradiol on calcium and phosphorus metabolism in osteoporosis. Clin. Sci. 34:411–417, 1968.Google Scholar
  13. 13.
    Katz, F.H. and Kappas, A.: The effect of natural estrogens on hydroxyproline excretion in man. J. Clin. Invest. 44: 1063, 1965.Google Scholar
  14. 14.
    Kühn, K., Stecher, K., Iwangoff, P., Hammerstein, F., Durruti, M., Holzmann, H. and Körting, G.W.: Studies on the metabolism of collagen III. The incorporation of (14C) glycine into the collagen of rats treated with progesterone. Biochem. Z. 343:528–536, 1965.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • Stephen M. Krane
    • 1
  1. 1.Departments of MedicineHarvard Medical School and Massachusetts General HospitalBostonUSA

Personalised recommendations