Clinical Course and Laboratory Data in Hypertension Associated with Oral Contraceptives

  • J. A. Luetscher
  • M. H. Weinberger
  • A. J. Dowdy
  • G. W. Nokes


During the past two years, four reports have appeared, indicating that hypertension occurs in some women taking estrogengestagen combinations for control of conception or menstrual irregularities. Swaab (1) suggested that blood pressure could increase markedly during the use of oral contraceptives. Laragh (2) presented data on eleven patients with hypertension during contraceptive administration. In six of these patients, hypertension was first noted after starting medication. Six of the eight patients who stopped medication showed improvement or disappearance of the hypertension. In two cases, hypertension reappeared when medication was re-instituted. Woods (3) reported six patients with hypertension which was precipitated or aggravated by oral contraceptives.


Oral Contraceptive Plasma Renin Activity Plasma Renin Primary Aldosteronism Aldosterone Secretion 
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  1. 1.
    Swaab, L.I.: Blood pressure and oral contraception, in Proceedings of Second International Congress on Hormonal Steroids, Milan, Romanoff, E.B. and Martini, L. (eds.) Excerpta Medica Foundation, p. 198.Google Scholar
  2. 2.
    Laragh, J.H., Sealey, J.E., Ledingham, J.G.G. and Newton, M.A.: Oral contraceptives. Renin, aldosterone and high blood pressure. J. Amer. Med. Assoc. 201:918–922 (1967).CrossRefGoogle Scholar
  3. 3.
    Woods, J.W.: Oral contraceptives and hypertension. Lancet 2:653–654 (1967).PubMedCrossRefGoogle Scholar
  4. 4.
    Tyson, J.E.A.: Oral contraception and elevated blood pressure. Amer. J. Obstet. Gynec. 100;875–876 (1968).PubMedGoogle Scholar
  5. 5.
    Weinberger, M.H., Dowdy, A.J., Nokes, G.W. and Luetscher, J.A.: Plasma renin activity and aldosterone secretion in hypertensive patients during high and low sodium intake and administration of diuretic. J. Clin. Endocr. 28:359 (1968).PubMedCrossRefGoogle Scholar
  6. 6.
    Weinberger, M.H., Dowdy, A.J., Nokes, G.W. and Luetscher, J,A.: Reversible increases in plasma renin activity, aldosterone secretion, and blood pressure in women taking oral contraceptive preparations. Clin. Res. 16:150 (1968).Google Scholar
  7. 7.
    Helmer, O.M. and Griffith, R.S.: The effect of the administration of estrogens on the renin-substrate (hypertensinogen) content of rat plasma. Endocrinology 51:421 (1952).PubMedCrossRefGoogle Scholar
  8. 8.
    Brown, J.J., Davies, D.L., Doak, P.B., Lever, A.F. and Robertson, J.I.S.: Plasma renin in normal pregnancy. Lancet ii:900 (1963).CrossRefGoogle Scholar
  9. 9.
    Helmer, O.M. and Judson, W.E.: Influence of high renin substrate levels on renin-angiotensin system in pregnancy. Amer. J. Obstet. Gynec. 99:9–17 (1967).PubMedGoogle Scholar
  10. 10.
    Crane, M.G., Heitsch, J., Harris, J. and Johns, V.J., Jr.: Effect of ethinyl estradiol (estinyl) on plasma renin activity. J. Clin Endocr. 26:1403 (1966).CrossRefGoogle Scholar
  11. 11.
    11: Newton, M.A., Sealey, J.E., Ledingham, J.G.G. and Laragh, J.H,: High blood pressure and oral contraceptives. Amer. J. Obstet. Gynec. 101:1037–1045 (1968).Google Scholar
  12. 12.
    Boucher, R., Veyrat, R., deChamplain, J. and Genest, J.: New procedures for measurement of human plasma angiotensin and renin activity levels. Canad. Med. Assoc. J. 90:194 (1964).PubMedGoogle Scholar
  13. 13.
    Laidlaw, J.C., Ruse, J.L. and Gomall, A.G.: The influence of estrogen and progesterone on aldosterone excretion. J. Clin.Endocr. 22:161 (1962).PubMedCrossRefGoogle Scholar
  14. 14.
    Layne, D.S., Meyer, C.J., Vaishwanar, P.S. and Pincus, G.: The secretion and metabolism of Cortisol and aldosterone in normal and in steroid treated women. J. Clin. Endocr. 22:107 (1962).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • J. A. Luetscher
    • 1
  • M. H. Weinberger
    • 1
  • A. J. Dowdy
    • 1
  • G. W. Nokes
    • 1
  1. 1.Department of MedicineStanford Medical CenterPalo AltoUSA

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