Effect of Gonadal Hormones on Adrenocortical Secretion and Its Significance

  • F. H. Katz


Alterations of adrenocortical secretion during pregnancy and differences between males and females of various species have been extensively studied for many years and it would be beyond the limitation of this brief survey to attempt to cover this entire field. We will therefore review the highlights of work done in this area especially as it affects our understanding of normal human physiology and alterations that occur with hormone treatment in man. In addition, work from our laboratory will be discussed.


Sodium Excretion Secretion Rate Cortisol Secretion Gonadal Hormone Ethinyl Estradiol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gemzell, C.A.: Blood levels of 17-hydroxycorticosteroids in normal pregnancy. J. Clin. Endocrin. Metab. 13:898 (1953).CrossRefGoogle Scholar
  2. 2.
    Taliaferro, I., Cobey, F. and Leone, L.: Effect of diethylstilbestrol on plasma 17-hydroxycorticosteroid levels in humans. Proc. Soc. Exp. Biol. Med. 92:742 (1956).PubMedGoogle Scholar
  3. 3.
    Wallace, E.Z., Silberberg, H.I. and Carter, A.C.: Effect of ethinyl estradiol on plasma 17-hydroxycorticosteroids, ACTH responsiveness, and hydrocortisone clearance in man. Proc. Sei. Exp. Biol. Med. 95:805 (1957).Google Scholar
  4. 4.
    Sandberg, A.A., Woodruff, M., Rosenthal, H., Nienhouse, S. and Slaunwhite, W.R.: Transcortin: a corticosteroid-binding protein of plasma. VII. Half-life in normal and estrogen-treated subjects. J. Clin. Invest. 43:461 (1964).PubMedCrossRefGoogle Scholar
  5. 5.
    Katz, F.H. and Kappas, A.: The effects of estradiol and estriol on plasma levels of Cortisol and thyroid hormone-binding globulins and on aldosterone and Cortisol secretion rates in man. J. Clin. Invest. 46:1768 (1967).PubMedCrossRefGoogle Scholar
  6. 6.
    Plager, J.E., Schmidt, K.G. and Staubitz, W.J.: Increased unbound Cortisol in the plasma of estrogen-treated subjects. J. Clin. Invest. 43:1066 (1964).PubMedCrossRefGoogle Scholar
  7. 7.
    Doe, R.P., Dickinson, P.B., Swain, W.R., Zinneman, H.H. and Seal, U.S.: Nonprotein-bound 17-OHCS at 9 A.M. and 9 P.M. in normals, pregnancy, estrogen-treated females and males with cancer of the prostrate. Program, 49th meeting of the Endocrine Society, Abstract No. 80 (1967).Google Scholar
  8. 8.
    Katz, F.H. and Shannon, I.L.: Parotid fluid Cortisol and cortisone. In preparation.Google Scholar
  9. 9.
    Peterson, R.E., Nokes, G., Chen, P.S. and Black, R.L.: Estrogens and adrenocortical function in man. J. Clin. Endocrin. Metab. 20:495 (1960).CrossRefGoogle Scholar
  10. 10.
    Cope, C.L. and Black, E.: The hydrocortisone production in late pregnancy. J. Obstet. Gynec. Brit. Emp. 66:404 (1959).CrossRefGoogle Scholar
  11. 11.
    Migeon, C.J., Kenny, F.M. and Taylor, F.H.: Cortisol production rate. VIII. Pregnancy. J. Clin. Endocrin. Metab. 28:661 (1968).CrossRefGoogle Scholar
  12. 12.
    Layne, D.S., Meyer, C. J., Vaishwanar, P.S. and Pincus, G.: The secretion and HBtabolism of Cortisol and aldosterone in normal and in steroid treated women. J. Clin. Endocr. Metab. 22:107 (1962).PubMedCrossRefGoogle Scholar
  13. 13.
    Gray, M.J., Strausfeld, K.S., Watanabe, M., Sims, E.A.H. and Solomon, S.: Aldosterone secretory rates in the normal menstrual cycle. J. Clin. Endocrin. Metab. 28:1269 (1968).CrossRefGoogle Scholar
  14. 14.
    Watanabe, M., Meeker, I., Gray, M.J., Sims, E.A.H. and Solomon, S.: Secretion rate of aldosterone in normal pregnancy. J. Clin. Invest. 42:1619 (1963).PubMedCrossRefGoogle Scholar
  15. 15.
    Crane, M.G., Heitsch, J., Harris, J.J. and Johns, V.J.: Effect of ethinyl estradiol (Estinyl) on plasma renin activity. J. Clin. Endocrin. Metab. 26:1403 (1966).CrossRefGoogle Scholar
  16. 16.
    Brown, J.J., Davies, D.L., Doak, P.B., Lever, A.F. and Robertson, J.I.S.: Serial estimation of plasma renin concentration during pregnancy and after parturition. J. Endocrin. 35:373 (1966).CrossRefGoogle Scholar
  17. 17.
    Landau, R.L. and Lugibihl, K.: Inhibition of the sodium- retaining influence of aldosterone by progesterone. J. Clin. Endocrin. Metab. 18:1237 (1958).CrossRefGoogle Scholar
  18. 18.
    Landau, R.L. and Lugibihl, K.: The catabolic and natriuretic effects of progesterone in man. Recent Prog. Hormone Res. 17:249 (1961).Google Scholar
  19. 19.
    Laidlaw, J.C., Ruse, J.L. and Gomall, A.G.: The influence of estrogen and progesterone on aldosterone excretion. J. Clin. Endocrin. Metab. 22:161 (1962).CrossRefGoogle Scholar
  20. 20.
    Kagawa, C.M. and Jacobs, R.S.: Action of testosterone in blocking urinary electrolyte effects of desoxycorticosterone. Proc. Soc. Exp. Biol. Med. 120:512 (1959)Google Scholar
  21. 21.
    Williamson, E.E.: Natriuretic action of certain adrenocortical androgens. Steroids 6:365 (1965).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • F. H. Katz
    • 1
  1. 1.Section of Endocrinology, Department of MedicineLoyola University, Stritch School of MedicineHinesUSA

Personalised recommendations