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The Effect of Natural and Synthetic Estrogens on the Excretion of BSP by the Liver

  • R. H. Palmer
  • T. F. GallagherJr.
  • M. N. Mueller
  • A. Kappas

Abstract

There is now general agreement that cholestasis and/or impairment of certain liver functions can be caused by a wide variety of steroids, including androgens (1), estrogens (1–5), progestins (1,6,7) and bile salts (8,9). (For a recent review and bibliography, see Song and Kappas (10)). Many of these steroids are synthetic or unsaturated steroids, often alkylated at the 17 position. This discussion will emphasize the capacity of natural estrogens to impair hepatic excretion of sulfobromophthalein in man, and will examine certain structural aspects of this activity in the rat.

Keywords

Bile Salt Bile Flow Synthetic Estrogen Natural Estrogen Bile Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • R. H. Palmer
    • 1
    • 2
  • T. F. GallagherJr.
    • 1
    • 2
  • M. N. Mueller
    • 1
    • 2
  • A. Kappas
    • 1
    • 2
  1. 1.Department of Medicine and Argonne Cancer Research HospitalThe University of ChicagoChicagoUSA
  2. 2.The Rockefeller UniversityNew YorkUSA

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