The Effect of Natural and Synthetic Estrogens on the Excretion of BSP by the Liver
There is now general agreement that cholestasis and/or impairment of certain liver functions can be caused by a wide variety of steroids, including androgens (1), estrogens (1–5), progestins (1,6,7) and bile salts (8,9). (For a recent review and bibliography, see Song and Kappas (10)). Many of these steroids are synthetic or unsaturated steroids, often alkylated at the 17 position. This discussion will emphasize the capacity of natural estrogens to impair hepatic excretion of sulfobromophthalein in man, and will examine certain structural aspects of this activity in the rat.
KeywordsBile Salt Bile Flow Synthetic Estrogen Natural Estrogen Bile Acid Excretion
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