Advertisement

Oral Contraceptives and High Blood Pressure: Changes in Plasma Renin, Renin Substrate and Aldosterone Excretion

  • J. H. Laragh
  • M. A. Newton
  • J. E. Sealey
  • J. G. G. Ledingham

Abstract

In this communication I will review for you studies, stimulated by clinical observations in certain of our hypertensive patients, which first suggested the possibility of a cause and effect relationship between the use of oral contraceptives and either the development or enhancement of high blood pressure.

Keywords

Oral Contraceptive High Blood Pressure Plasma Renin Activity Plasma Renin Renin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Laragh, J.H., Sealey, J.E., Ledingham, J.G.G. and Newton, M.A.: Oral contraceptives. Renin, aldosterone and high blood pressure. J.A.M.A. 201;918 (1967).PubMedCrossRefGoogle Scholar
  2. 2.
    Helmer, O.M. and Griffith, R.S.: The effect of the administration of estrogens on the renin-substräte (hypertensinogen) content of rat plasma. Endocrinology 51: 421 (1952).PubMedCrossRefGoogle Scholar
  3. 3.
    Layne, D.S., Meyer, C. J., Vaishwanar, P.S. and Pincus, G.: The secretion and metabolism of Cortisol and aldosterone in normal and in steroid-treated women. J. Clin. Endocr. 22: 107 (1962).PubMedCrossRefGoogle Scholar
  4. 4.
    Laidlaw, J.C., Ruse, J.L. and Gomall, A.G.: The influence of estrogen and progesterone on aldosterone excretion. J. Clin. Endocr.22:161 (1962).PubMedCrossRefGoogle Scholar
  5. 5.
    Brown, J.J., Davies, D.L., Doak, P.B., Lever, A.F. and Robertson, J.I.S.: Plasma renin in normal pregnancy. Lancet ii: 900 (1963).CrossRefGoogle Scholar
  6. 6.
    Winer, B.M.: Renin in pregnancy and the menstrual cycle. J. Clin. Invest. 44: 112 (1965).Google Scholar
  7. 7.
    Genest, J., de Champlain, J. Veyrat, R., Boucher, R., Tremblay, G.Y,, Strong, C.G., Koiw, E. and Marc-Aurele, J.: Role of the renin-angiotensin system in various physiological and pathological states in Proc. Council for High Blood Pressure Research 13:97 (1964).Google Scholar
  8. 8.
    Crane, M.G., Heitsch, J., Harris, J. and Johns, V.J., Jr.: Effect of ethinyl estradiol (estinyl) on plasma renin activity. J. Clin. Endocr. 26: 1403 (1966).CrossRefGoogle Scholar
  9. 9.
    Woods, J.W.: Oral contraceptives and hypertension. Lancet ii: 653 (1967).CrossRefGoogle Scholar
  10. 10.
    Laragh, J.H., Sealey, J.E. and Sommers, S.C.: Patterns of adrenal secretion and urinary excretion of aldosterone and plasma renin activity in normal and hypertensive subjects. Circ. Res. Suppl. I, 18 & 19: 1–158, 1966.Google Scholar
  11. 11.
    Laragh, J.H., Sealey, J.E. and Klein, P.D.: The presence and effect of isotope fractionation in isotope dilution analysis: A factor in the measurement of aldosterone secretory rates in man, in Radiochemical Methods of Analysis, Vienna: International Atomic Energy Agency, 2: 353 (1965).Google Scholar
  12. 12.
    Pickens, P.T., Bumpus, F.M., Lloyd, A.M., Smeby, R.R. and Page, I.H.: Measurement of renin activity in human plasma. Circ. Res. 17:438 (1965).PubMedGoogle Scholar
  13. 13.
    Haas, E., Goldblatt, H. and Gipson, E.C.: Extraction, purification and acetylation of human renin and the production of anti-renin to human renin. Arch. Biochem. 110:438 (1965).CrossRefGoogle Scholar
  14. 14.
    Haas, E. and Goldblatt, H.: Kinetic constants of the human renin and human angiotensinogen reaction. Circ. Res. 20:45 (1967).PubMedGoogle Scholar
  15. 15.
    Skinner, S.L.: Improved assay methods for renin "concentration" and "activity" in human plasma. Circ. Res. 29: 391 (1967).Google Scholar
  16. 16.
    Swaab, L.I.: Blood pressure and oral contraception. Proceedings of Second International Congress on Hormonal Steroids, Milan, Italy, Amsterdam, Excerpta Medica Foundation, 1966, p. 198.Google Scholar
  17. 17.
    Shapiro, A.P.: Personal communication.Google Scholar
  18. 18.
    Thomas, C.B.: Some observations on the relationship between weight changes following sodium restriction and those associated with the menstrual cycle in normal young women. Ann. Int. Med. 39:289 (1953).PubMedGoogle Scholar
  19. 19.
    Braun-Menendez, E., Fasciola, J.C., Leloir, L.F., Muno, J.M. and Taquini, A.C.: Renal Hypertension, Springfield, 111. Charles C. Thomas, Publisher, p. 130, (1946).Google Scholar
  20. 20.
    Meyer, C.J., Layne, D.S., Tait, J.F. and Pincus, G.: The binding of aldosterone to plasma proteins in normal, pregnant and steroid-treated women. J. Clin. Invest. 40:1663 (1961).PubMedCrossRefGoogle Scholar
  21. 21.
    Ayers, C.R.: Plasma renin activity and renin-substräte concentration in patients with liver disease. Circ. Res. 20:594 (1967).PubMedGoogle Scholar
  22. 22.
    Cole, M.: Strokes in young women using oral contraceptives. Arch. Int. Med. 120:551 (1967).CrossRefGoogle Scholar
  23. 23.
    The Veterans Administration Co-operative Urological Research Group: Treatment and survival of patients with cancer of the prostrate. Surg. Gyn. & Ob. 124:1011 (1967).Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • J. H. Laragh
    • 1
  • M. A. Newton
    • 1
  • J. E. Sealey
    • 1
  • J. G. G. Ledingham
    • 1
  1. 1.Department of Medicine, College of Physicians and Surgeons, and the Presbyterian Hospital in the City of New YorkColumbia UniversityUSA

Personalised recommendations