Advertisement

The Effects of Gonadal Hormones and Contraceptive Steroids on Tryptophan Metabolism

  • D. P. Rose

Abstract

The pathway by which tryptophan is metabolized to yield nicotinic acid ribonucleotide has been the subject of considerable interest in recent years. Abnormal urinary excretion of metabolites of this pathway in vitamin B6 deficiency has led to the extensive use of a tryptophan load test for the study of pyridoxine requirements in man (1–3).

Keywords

Urinary Excretion Quinolinic Acid Ethinyl Estradiol Anthranilic Acid Gonadal Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Greenberg, L.D., Bohr, D.F., McGrath, H., and Rinehart, J.F.: Xanthurenic acid excretion in the human subject on a py- ridoxine-deficient diet. Arch. Biochem. 21:237–239 (1949).PubMedGoogle Scholar
  2. 2.
    O’Brien, D. and Jensen, C.B.: Pyridoxine dependency in two mentally retarded subjects. Clin. Sci. 24:179–186 (1963).Google Scholar
  3. 3.
    Yess, N., Price, J.M., Brown, R.R., Swan, P.B., and Linkswiler, H.: Vitamin Bg depletion in man: Urinary excretion of tryptophan metabolites. J. Nutr. 84:229–236 (1964).PubMedGoogle Scholar
  4. 4.
    Ogasawara, N., Hagino, Y., and Kotake, Y.: Kynurenine transaminase, kynureninase, and the increase of xanthurenic acid excretion. J. Biochem. (Tokyo) 52: 162–166 (1962).Google Scholar
  5. 5.
    Sprince, H., Lowy, R.S., Folsome, C.E., and Behrman, J.S.: Studies on the urinary excretion of ’ xanthurenic acid’ during normal and abnormal pregnancy; a survey of the excretion of ’xanthurenic acid’ in normal non-pregnant, normal pregnant, pre-eclamptic, and eclamptic women. Am. J. Obstet. Gynec. 62: 84–92 (1951).PubMedGoogle Scholar
  6. 6.
    Wachstein, M. and Lobel, S.: Abnormal tryptophan metabolites in human pregnancy and their relation to deranged vitamin & metabolism. Proc. Soc. Exptl. Biol. Med. 86:624–627 (1954).Google Scholar
  7. 7.
    Brown, R.R., Thornton, M. J., and Price, J.M.: The effect of vitamin supplementation on the urinary excretion of tryptophan metabolites by pregnant women. J. Clin. Invest. 40:617–623 (1961).PubMedCrossRefGoogle Scholar
  8. 8.
    Hernandez, T.: Tryptophan metabolite excretion in pregnancy after a tryptophan load. Fed. Proc. 23:136 (1964).Google Scholar
  9. 9.
    Michael, A.F., Drummond, K.N., Doeden, D., Anderson, J.A., and Good, R.A.: Tiryptophan metabolism in man. J. Clin. Invest. 43: 1730–1746 (1964).PubMedCrossRefGoogle Scholar
  10. 10.
    Rose, D.P.: The influence of sex, age and breast cancer on tryptophan metabolism. Clin. Chim. Acta 18:221–225 (1967).PubMedCrossRefGoogle Scholar
  11. 11.
    Brown, J.B.: Urinary excretion of oestrogens during the menstrual cycle. Lancet i:320–323 (1955).Google Scholar
  12. 12.
    Rose, D.P.: The influence of oestrogens on tryptophan metabolism in man. Clin. Sci. 31:265–272 (1966).PubMedGoogle Scholar
  13. 13.
    Price, J.M., Thornton, M.J., and Mueller, L.M.: Tryptophan metabolism in women using steroid hormones for ovulation control. Am. J. Clin. Nutr. 20:452–456 (1967).PubMedGoogle Scholar
  14. 14.
    Rose, D.P., Brown, R.R., and Price, J.M.: Metabolism of tryptophan to nicotinic acid derivatives by women taking oestrogen-progestogen preparations. Nature 219:1259–1260 (1968).PubMedCrossRefGoogle Scholar
  15. 15.
    Gluecksohn-Waelsch, S., Greengard, P., Quinn, G.P., and Teicher, L.S.: Genetic variations of an oxidase in mammals. J. Biol. Chem. 242: 1271–1273 (1967).PubMedGoogle Scholar
  16. 16.
    Rose, D.P.: Penicillamine and pyridoxine in man. Lancet i: 489–490 (1966).CrossRefGoogle Scholar
  17. 17.
    Brown, R.R., Yess, N., Price, J.M., Linkswiller, H., Swan, P., and Hankes, L.V.: Vitamin Bg depletion in man: urinary excretion of quinolinic acid and niacin metabolites. J. Nutr. 87: 419–423 (1965).PubMedGoogle Scholar
  18. 18.
    Civen, M. and Knox, W.E.: The independence of hydrocortisone and tryptophan inductions of tryptophan pyrrolase. J. Biol. Chem. 234:1787–1790 (1959).PubMedGoogle Scholar
  19. 19.
    Altman, K. and Greengard, 0.: Correlation of kynure- nine excretion with liver tryptophan pyrrolase levels in disease and after hydrocortisone induction. J. Clin. Invest. 45:1527–1534 (1966).PubMedCrossRefGoogle Scholar
  20. 20.
    Rose, D.P. and McGinty, F.: The influence of adrenocortical hormones and vitamins upon tryptophan metabolism in man. Clin. Sci. 35:1–9 (1968).PubMedGoogle Scholar
  21. 21.
    Greengard, P., Kalinsky, H.J., and Manning, T.J.: Tryptophan pyrrolase activity during pregnancy. Biochim. Biophys. Acta 156: 198–199 (1968).PubMedCrossRefGoogle Scholar
  22. 22.
    Rose, D.P. and Brown, R.R.: In preparation.Google Scholar
  23. 23.
    Mainardi, L.: Aspetti de metabolismo del triptofano nella gravidanza di animali di specie diversa. Acta Vitaminol. (Milan) 3:110–116 (1957).Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • D. P. Rose
    • 1
  1. 1.University Department of Chemical PathologyThe Royal InfirmarySheffield S6 3DAEngland

Personalised recommendations