Advertisement

Progesterone: Mechanism of Action

  • B. W. O’Malley

Abstract

In 1672, Regner de Graaf first published a description of the corpus luteum and recognized that the presence of a corpus luteum is associated with a fetus in utero. The definitive experiments of Comer (1), Allen and Reynolds (2) showed that pregnancy in rabbits is controlled by a product of the corpus luteum — the ovarian steroid progesterone. Nevertheless, at present there is no unifying concept which would define the major role of progesterone in animal tissues. Furthermore, the biochemical actions of this steroid at the molecular level of cell metabolism have been so elusive that it is difficult even to construct a good hypothetical mechanism of action. The biologic effects of progesterone may be grouped as follows: (1) uterine endometrial cells are transformed in such a way that they may receive the early embryo and facilitate its implantation; (2) myometric activity is suppressed, aiding in retention of the embryo during implantation and growth prior to normal parturition; (3) numerous and varied metabolic parameters may be altered which may have no direct impact on maintenance and termination of pregnancy.

Keywords

Amino Acid Metabolism Myometrial Cell Uterine Muscle General Protein Synthesis Oviduct Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Comer, G.W.: The Hormones in Human Re product ion Princeton University Press, Princeton, p. 281 (1947).Google Scholar
  2. 2.
    Reynolds, S.R.M.: Physiology of the Uterus. P.B. Hoeber, Inc., New York p.611 (1949).Google Scholar
  3. 3.
    Csapo, A. Brook Lodge Symposium of Progesterone, Brook Lodge Press, Augusta, Michigan, p. 7 (1961).Google Scholar
  4. 4.
    Goto, M. and Csapo, A.: Biol. Bull. 115:335 (1958).Google Scholar
  5. 5.
    Marshall, J. and Csapo, A.: Biol. Bull. 117:419 (1959).Google Scholar
  6. 6.
    Mueller, G.C.: J. Biol. Chem. 204:77 (1953).PubMedGoogle Scholar
  7. 7.
    Wagatsuma, T., Sullivan, W.J. and Kumar, D.: Amer. J. Obstet. Gynecol. 98:1050 (1967).Google Scholar
  8. 8.
    Varricchio, F.: Arch. Biophys. 121:187 (1967).CrossRefGoogle Scholar
  9. 9.
    Brant, J.W.A. and A.V. Nalbandov: Poultry Sei. 35:692 (1956).Google Scholar
  10. 10.
    O’;Malley, B.W., McGuire, W.L. and Korenman, S.G.: Biochem. Biophys. Acta. 145:204 (1967).Google Scholar
  11. 11.
    Hertz, R., Fraps, R.M. and Sebrell, W.E.: Proc. Soc. Exptl. Biol. Med. 52:142 (1943).Google Scholar
  12. 12.
    Korenman, S.G. and O’;Malley, B.W.: Endocrinology 83:11 (1968).PubMedCrossRefGoogle Scholar
  13. 13.
    Korenman, S.G. and O’;Malley, B.W.: Biochem. Biophys. Acta 140:174 (1967).Google Scholar
  14. 14.
    O’;Malley, B.W. and Korenman, S.G.: Life Sciences 6:1953 (1967).CrossRefGoogle Scholar
  15. 15.
    O’;Malley, B.W.: Biochemistry 6: 2546 (1967).CrossRefGoogle Scholar
  16. 16.
    McGuire, W.L. and O’;Malley, B.W.: Biochem. Biophys. Acta 157:187 (1968).PubMedGoogle Scholar
  17. 17.
    Barker, K.L. and Warren, J.C.: Proc. Natl. Acad. Sci. 56:1298 (1966).PubMedCrossRefGoogle Scholar
  18. 18.
  19. 19.
    O’;Malley, B. W. and McGuire, W. L.: Proc. Natl. Acad. Sci. 60: 1527 (1968).CrossRefGoogle Scholar
  20. 20.
    Hahn, Church, R.B., Gorbman, A. and Willmot, L.: Gen. Comp. Endocrinology (in press).Google Scholar
  21. 21.
    Soeira, R., Birnboim, H. C., and Darnell, J. E.: J.Mol. Biol.19: 362 (1966).CrossRefGoogle Scholar
  22. 22.
    Shearer, R. W., and McCarthy, B. J.: Biochemistry 6: 283 (1967).PubMedCrossRefGoogle Scholar
  23. 23.
    O’;Malley, B. W., McGuire, W. L., Kohler, P. O., and Korenman, S. G.: Recent Progress in Hormone Research, Vol. 29 (1969), in press.Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • B. W. O’Malley
    • 1
  1. 1.Endocrinology Branch, National Cancer InstituteNational Institutes of HealthMarylandUSA

Personalised recommendations