Acquired Subclinical Diabetes Mellitus in Women Receiving Oral Contraceptive Agents
Although several conflicting observations have been reported concerning the effects of oral contraceptive agents on standard glucose tolerance tests, there is little doubt that the frequency of abnormal steroid-provocative glucose tolerance tests (GTT) is extraordinarily high among subjects on this regimen. diPaola and I co-workers (1) and Gershberg and associates (2) have observed independently that the incidence of positive steroid tests in: women receiving agents containing mestranol ranges from 45 to 85 percent or 10 to 20-fold greater than a general population. These findings imply that oral contraceptives induce an acquired form of subclinical diabetes mellitus. Possible etiologies of this defect and its reversibility after discontinuation of birth control medications are the subjects of this presentation.
KeywordsInsulin Response Ideal Body Weight Negative Family History Birth Control Pill Cortisone Acetate
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