Mechanism of Action of β-Lactamases and DD-Peptidases

  • Jean-Marie Frère
  • Bernard Joris
  • Françoise Jacob
  • André Matagne
  • Didier Monnaie
  • Marc Jamin
  • Médar Hadonou
  • Catherine Bourguignon-Bellefroid
  • Louis Varetto
  • Jean-Marc Wilkin
  • Alain Dubus
  • Christian Damblon
  • Maggy Adam
  • Philippe Ledent
  • Fabien De Meester
  • Moreno Galieni
Chapter
Part of the NATO ASI Series book series (NSSA, volume 207)

Abstract

The introduction of penicillins as antibacterial agents probably represents one of the major breakthroughs of chemotherapy during the present century. However, the bacterial world did not remain without reaction and resistance to strains started to appear almost as soon as penicillin utilisation became popular. This resulted in an endless race between the chemists and the microbiologists on one side and the bacteria on the other, the formers discovering and synthesizing new compounds while the latters found new tricks to escape their lethal action so that the ß-lactam family now comprises molecules of widely different structures of which the ß-lactam ring remains the only common feature (Figure 1A).

Keywords

Serine Residue Neisseria Gonorrhoeae Peptidoglycan Biosynthesis Transpeptidation Reaction Serine Hydroxyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Jean-Marie Frère
    • 1
  • Bernard Joris
    • 1
  • Françoise Jacob
    • 1
  • André Matagne
    • 1
  • Didier Monnaie
    • 1
  • Marc Jamin
    • 1
  • Médar Hadonou
    • 1
  • Catherine Bourguignon-Bellefroid
    • 1
  • Louis Varetto
    • 1
  • Jean-Marc Wilkin
    • 1
  • Alain Dubus
    • 1
  • Christian Damblon
    • 1
  • Maggy Adam
    • 1
  • Philippe Ledent
    • 1
  • Fabien De Meester
    • 1
  • Moreno Galieni
    • 1
  1. 1.Center for Protein Engineering and Laboratoire d’EnzymologieUniversité de Liège, Institut de Chimie, B6, Sart TilmanLiègeBelgium

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