Coronaviruses pp 455-463 | Cite as

Genetically-Determined Sensitivity to MHV3 Infections is Expressed in Vitro in Lymphoid Cells and Macrophages

  • J. M. Dupuy
  • L. Lamontagne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)


Natural resistance of mice to viruses is an excellent model to study genetically-controlled virus-lymphoid cell interactions. Hepatitis virus type 3 (MHV3) infection displays various types of sentivity according to the mouse strains tested: resistance, full susceptibility to acute disease or semisusceptibility which is characterized by the occurrence of persistent viral infection with development of neurological signs. A/J strain mice are resistant to MHV3 infection but immunosuppressive treatments can abrogate the resistance1. Protection of newborn mice against MHV3 infection requires the transfer of several populations originating from adult syngeneic donors: adherent spleen cells, thymocytes and a third population present in the non-adherent spleen cell fraction, in peritoneal exudate and bone marrow cells2.


Peritoneal Exudate Peritoneal Exudate Cell Mouse Hepatitis Virus Infectious Viral Particle Persistent Viral Infection 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. M. Dupuy
    • 1
  • L. Lamontagne
    • 1
  1. 1.Immunology Research Center, Institut Armand-Frappier, and Dépt Sciences BiologiquesUniversité du Québec à MontréalMontréalCanada

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