Characterization of Mouse Hepatitis Virus-Reactive T Cell Clones
- 489 Downloads
Mouse hepatitis virus (MHV) is a member of the family Coronaviridae and known to induce various types of disease, hepatitis, enteritis and encephalitis in mice depending upon the host strain, age, and immune status1. Using nude or immunomodulated mice, T cell-mediated immunity in MHV infections was suggested to play an important role.2, 3 By the adoptive transfer of spleen cells from immune euthymic mice the growth of MHV in the recipient nude mice was inhibited, and the transfer effect was abolished by treating immune spleen cells with anti-BAT serum and complement3.
KeywordsCell Clone Spleen Cell Stimulator Cell Mouse Hepatitis Virus Hind Footpad
- 6.S. Kyuwa and K. Fujiwara, Delayed-type hypersensitivity in mouse hepatitis virus infection in mice, Japan J. Exp. Med. 54: 81 (1984).Google Scholar
- 10.K. Fujiwara, Problems in checking innaparent infections in laboratory mouse colonies. An attempt at serological checking by anamnestic response, in: “Defining of the laboratory animals”, H. A. Scheneider, ed., National Academy of Science, Washington, D. C. (1971).Google Scholar
- 15.D. P. Dialynas, Z. S. Quan, K. A. Wall, A. Pierres, J. Quintan, M. R. Loken, M. Pierres, and F. W. Fitch, Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Lue-3/T4 molecule, J. Immunol. 131: 2445 (1983).PubMedGoogle Scholar
- 21.R. D. Schrier, L. I. Pizer, and J. W. Moorhead, Type-specific delayed hypersensitivity and protective immunity induced by isolated herpes simplex virus glycoprotein, J. Immuni. 130: 1413 (1983).Google Scholar