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Coronaviruses pp 333-342 | Cite as

Pathogenic Characteristics of Neutralization-Resistant Variants of JHM Coronavirus (MHV-4)

  • J. O. Fleming
  • M. D. Trousdale
  • S. A. Stohlman
  • L. P. Weiner
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

One of the most interesting aspects of murine coronaviruses is their ability to cause model, experimental neurological diseases in animals (1–10). In this situation, disease obviously depends on complex interactons between virus, host, and environment. The initial focus of our group has been to consider the specifically viral determinants of disease. We have adopted this approach because the virus is the least complex element of this biological system. Hopefully, the elucidation of viral components which play critical roles during disease will provide a basis for more general explanations of pathogenesis, including consideration of the host and environment.

Keywords

Rabies Virus Plaque Form Unit Mouse Hepatitis Virus Double Variant Murine Coronavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Weiner LP, Pathogenesis of demyelination induced by a mouse hepatitis virus (JHM virus). Arch. Neurol. 1973; 18: 298–303.CrossRefGoogle Scholar
  2. 2.
    Lampert PW, Sims JK, Kniazeff AJ. Mechanism of demyelination in JHM virus encephalomyelitis. Electronmicroscopic studies. Acta. Neuropathologica. 1973; 24: 76–85.PubMedCrossRefGoogle Scholar
  3. 3.
    Sorenson O, Percy D, and Dales S. In vivo and in vivo models of demyelination diseases. III. JHM virus infection of rats. Arch. Neurol. 1980; 37: 478–484.CrossRefGoogle Scholar
  4. 4.
    Stohlman SA, and Weiner LP. Chronic central nervous system demyelination in mice after JHM virus infection. Neurology 1981; 31: 38–44.PubMedCrossRefGoogle Scholar
  5. 5.
    Wege H, Siddell S, ter Meulen V. The biology and pathogenesis of coronaviruses. Curr. Top. Microbiol. Immunol. 1982; 99: 165–200.PubMedCrossRefGoogle Scholar
  6. 6.
    Martin JR, Nathanson N. Animal models of virus-induced demyelination. Prog. Neuropathol. 1979; 4: 27–50.Google Scholar
  7. 7.
    Dal Canto MC, Rabinowitz SG. Experimental models of virus-induced demyelination of the central nervous system. Ann. Neurol. 1982; 11: 109–127.CrossRefGoogle Scholar
  8. 8.
    Fleming JO. Animal models of multiple sclerosis. Mayo Clin. Proc. 1985; 60: 490–492.PubMedGoogle Scholar
  9. 9.
    Hirano N, Goto N, Makino S, Fujiwara K. Persistent infection with mouse hepatitis virus, JHM strain, in DBT cell culture. Adv. Exp. Med. Biol. 1981; 142: 301–308.PubMedGoogle Scholar
  10. 10.
    Knobler RL, Lampert PW, Oldstone MBA. Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4. Nature 1982; 298: 279–280.PubMedCrossRefGoogle Scholar
  11. 11.
    Laver WG. The use of monoclonal antibodies to investigate antigenic drift in influenza virus. In: Hurrell JGR, ed. Monoclonal hybridoma antibodies: techniques and applications. Boca Raton: CRC Press, 1982; 104–117.Google Scholar
  12. 12.
    Laver WG, Air GM, Webster RG, Markoff LJ. Amino acid sequence changes in antigenic variants of type A influenza N2 neuraminidase. Virology 1982; 122: 450–460.PubMedCrossRefGoogle Scholar
  13. 13.
    Evans DMA, Minor PD, Schild GC, Almond JW. Critical role of an eight amino sequence of VPI in neutralization of poliovirus type 3. Nature 1983; 304: 459–462.PubMedCrossRefGoogle Scholar
  14. 14.
    Knossow M, Daniels RS, Douglas AR, Skehel JJ, Wiley DC. Three-dimensional structure of an antigenic mutant of the influenza virus hemagglutinin. Nature 1984; 311: 678–680.PubMedCrossRefGoogle Scholar
  15. 15.
    Seif IP, Coulon P, Rollin PE, Flamand A. Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein. J. Virol. 1985; 53: 926–934.PubMedGoogle Scholar
  16. 16.
    Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J. Virol. 1986; 59: 90–97.PubMedGoogle Scholar
  17. 17.
    Dietzschold B, Wiktor TJ, Trojanowsi JQ, Macfarlan RI, Wunner WH, Torres-Anjel MJ, Koprowsky H. Differences in cell-to-cell spread of pathogenic and apathogenic rabies virus in vivo and in vivo. J. Virol. 1985; 56: 12–18.PubMedGoogle Scholar
  18. 18.
    Gonzales-Scarano F, Janssen RS, Najjar JA, Pobjecky, Nathanson N. An avirulent Gl glycoprotein variant of La Crosse bonyavirus with defective fusion function. J. Virol. 1985; 54: 757–763.Google Scholar
  19. 19.
    Love AR, Rydbeck R, Kristensson K, Orrell C, Norrby E. Hemagglutinin-neuraminidase glycoprotein as a determinant of pathogenicity in mumps virus hamster encephalitis: analysis of mutants selected with monoclonal antibodies. J. Virol. 1985; 53: 67–74.PubMedGoogle Scholar
  20. 20.
    Dalziel RG, Lampert PW, Talbot PJ, Buchmeier MJ. Site specific alteration of murine hepatitis virus type-4 (MHV-4) peplomer glycoprotein E2 results in reduced neurovirulence. J. Virol. 1986: 59: 463–471.PubMedGoogle Scholar
  21. 21.
    Portner A, Webster RG, Bean WJ. Similar frequencies of antigenic variants in Sendai, vesicular stomatitis, and influenza A viruses. Virology 1980; 104: 235–238.PubMedCrossRefGoogle Scholar
  22. 22.
    Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, and Vande Pol S. Rapid evolution of RNA genomes. Science 1982; 215: 1577–1585.PubMedCrossRefGoogle Scholar
  23. 23.
    Siddell S, Wege H, ter Meulen V. The structure and replication of coronaviruses. Curr. Top. Micro. Immunol. 1982; 99: 131–163.CrossRefGoogle Scholar
  24. 24.
    Fleming JO, Trousdale MD, El-Zaatari FAK, Stohlman SA, and Weiner LP. Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies. J. Virol. 1986; 58: 869–875.PubMedGoogle Scholar
  25. 25.
    Fleming JO, Trousdale MD, Bradbury JK, Stohlman SA, and Weiner LP. Experimental demyelination induced by coronavirus JHM (MHV-4): molecular identification of a viral determinant of paralytic disease. Microb. Pathogen. 1987; in press.Google Scholar
  26. 26.
    Stohlman SA, Brayton PR, Fleming JO, Weiner LP, Lai MMC. Murine coronaviruses: isolation and characterization of two plaque morphology variants of the JHM neurotropic strain. J. Gen. Virol. 1982; 63: 265–275.PubMedCrossRefGoogle Scholar
  27. 27.
    Stohlman SA, Fleming JO, Paton CD, Lai MMC. Synthesis and subcellular localization of the murine coronavirus nucleocapsid protein. Virology 1983; 130: 527–532.PubMedCrossRefGoogle Scholar
  28. 28.
    Fleming JO, Stohlman SA, Harmon RC, Lai MMC, Frelinger JA, Weiner LP. Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus. Virology 1983; 131: 296–307.PubMedCrossRefGoogle Scholar
  29. 29.
    Fields BN, Greene MI. Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment. Nature 1982; 300: 19–23.PubMedCrossRefGoogle Scholar
  30. 30.
    Makino S, Stohlman SA, Lai MMC. Leader sequences of murine coronavirus mRNA can be freely reassorted: evidence for the role of free leader RNA in transcription. Proc. Natl. Acad. Sci. USA 1986; 83: 4204–4208.PubMedCrossRefGoogle Scholar
  31. 31.
    Brayton PR, Lai MMC, Patton CD, Stohlman SA. Characterization of two RNA polymerase activities induced by mouse hepatitis virus. J. Virol. 1982; 42: 847–853.PubMedGoogle Scholar
  32. 32.
    Wege H, Dorries R, Wege H. Hybridoma antibodies to the murine coronavirus JHM: characterization of epitopes on the peplomer protein (E2). J. Gen. Virol. 1984; 65: 1931–1942.PubMedCrossRefGoogle Scholar
  33. 33.
    Talbot PJ, Salmi AA, Knobler RL, Buchmeier MJ. Topographical mapping of epitopes on the glycoproteins of murine hepatitis virus-4 (strain JHM): correlation with biological activities. Virology 1984; 132: 250–260.PubMedCrossRefGoogle Scholar
  34. 34.
    Schmidt I, Skinner M, Siddell S. Nucleotide sequence of the gene encoding the surface projection glycoprotein of coronavirus MHV-JHM. J. Gen. Virol. 1987; 68: 47–56.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. O. Fleming
    • 1
  • M. D. Trousdale
    • 1
  • S. A. Stohlman
    • 1
  • L. P. Weiner
    • 1
  1. 1.Departments of Neurology and MicrobiologyUniversity of Southern California Medical SchoolLos AngelesUSA

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