Coronaviruses pp 333-342 | Cite as

Pathogenic Characteristics of Neutralization-Resistant Variants of JHM Coronavirus (MHV-4)

  • J. O. Fleming
  • M. D. Trousdale
  • S. A. Stohlman
  • L. P. Weiner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)


One of the most interesting aspects of murine coronaviruses is their ability to cause model, experimental neurological diseases in animals (1–10). In this situation, disease obviously depends on complex interactons between virus, host, and environment. The initial focus of our group has been to consider the specifically viral determinants of disease. We have adopted this approach because the virus is the least complex element of this biological system. Hopefully, the elucidation of viral components which play critical roles during disease will provide a basis for more general explanations of pathogenesis, including consideration of the host and environment.


Rabies Virus Plaque Form Unit Mouse Hepatitis Virus Double Variant Murine Coronavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. O. Fleming
    • 1
  • M. D. Trousdale
    • 1
  • S. A. Stohlman
    • 1
  • L. P. Weiner
    • 1
  1. 1.Departments of Neurology and MicrobiologyUniversity of Southern California Medical SchoolLos AngelesUSA

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