Pathogenic Characteristics of Neutralization-Resistant Variants of JHM Coronavirus (MHV-4)
- 600 Downloads
One of the most interesting aspects of murine coronaviruses is their ability to cause model, experimental neurological diseases in animals (1–10). In this situation, disease obviously depends on complex interactons between virus, host, and environment. The initial focus of our group has been to consider the specifically viral determinants of disease. We have adopted this approach because the virus is the least complex element of this biological system. Hopefully, the elucidation of viral components which play critical roles during disease will provide a basis for more general explanations of pathogenesis, including consideration of the host and environment.
KeywordsRabies Virus Plaque Form Unit Mouse Hepatitis Virus Double Variant Murine Coronavirus
- 6.Martin JR, Nathanson N. Animal models of virus-induced demyelination. Prog. Neuropathol. 1979; 4: 27–50.Google Scholar
- 11.Laver WG. The use of monoclonal antibodies to investigate antigenic drift in influenza virus. In: Hurrell JGR, ed. Monoclonal hybridoma antibodies: techniques and applications. Boca Raton: CRC Press, 1982; 104–117.Google Scholar
- 18.Gonzales-Scarano F, Janssen RS, Najjar JA, Pobjecky, Nathanson N. An avirulent Gl glycoprotein variant of La Crosse bonyavirus with defective fusion function. J. Virol. 1985; 54: 757–763.Google Scholar
- 25.Fleming JO, Trousdale MD, Bradbury JK, Stohlman SA, and Weiner LP. Experimental demyelination induced by coronavirus JHM (MHV-4): molecular identification of a viral determinant of paralytic disease. Microb. Pathogen. 1987; in press.Google Scholar