Influence of the Cell Cycle on the Infectious Titer of Murine Hepatitis Virus, Strain A59
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Several studies have emphasized the importance of the cell growth phase in the gene expression of retroviruses and the polyomavirus SV40. On the other hand, scarce studies have correlated the efficiency of replication of other viruses with the cell cycle. Joseph et al. (1975) showed a 10,000-fold increase in Measles virus production after mitogenic stimulation of acutely infected lymphocytes. Ogura et al. (1984) correlated Sendai virus production in persistently infected cells with the cell growth phase. However, the observation only stemmed from a comparison of resting or actively growing cells. The same approach was used by Pons et al. (1983), who showed a 20- to 60-fold increase in respiratory syncytial virus production in actively growing HEp-2 cells.
KeywordsRespiratory Syncytial Virus Virus Production Mitogenic Stimulation Mouse Hepatitis Virus Cell Growth Phase
- Supported by National Sciences and Engineering Research Council of Canada (Grant UO387 and Scholarship to P.J.T.).Google Scholar