Temperature-Sensitive Mutants of MHV-A59
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Sequencing of complete coronavirus genomes will soon be accomplished, and the size and locations of all of the viral genes and the amino acid sequence of the gene products will then be apparent. These important advances will be a major aid to understanding the fascinating biology and pathogenesis of this group of viruses. The next goal will be to understand the interactions of viral macromolecules during coronavirus replication, and to identify domains on the viral proteins which are responsible for these molecular interactions.
KeywordsWild Type Virus Nucleocapsid Protein Complementation Group Mouse Hepatitis Virus Viral Structural Protein
- Holmes, K.V., 1984, Assembly of Coronaviridae, Chapter 7, pp. 100–119 in “Assembly of Enveloped RNA Viruses”, M. DuBois-Dalcq, K.V. Holmes, and B. Rentier, eds., Springer-Verlag, Vienna.Google Scholar