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Neurochemical Effects of Viral Infections in the Central Nervous System

  • K. W. Rammohan
  • A. A. Farooqui
  • L. A. Horrocks
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Abstract

In recent years it has become apparent that dysfunction of virus-infected cells occurs by a variety of mechanisms. Cells can harbor viruses and be unaffected, with regard to vital functions of cell division or cell differentiation. Similarly, virus persistence has been observed in vivo in the absence of any clinical illness, and these observations collectively raise the question as to what leads to cellular dysfunction in the course of a viral infection. Correlations of changes in specific molecular events to alterations in cellular function have recently been studied in a number of viral infections. Although a complete review of all viral systems studied in this regard is beyond the scope of this review, basic mechanisms highlighted by specific viral infections will be discussed such that many mechanisms by which viruses cause central nervous system (CNS) dysfunction will become evident.

Keywords

Rabies Virus Measle Virus Semliki Forest Virus Glycosyl Transferase Neurochemical Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • K. W. Rammohan
    • 1
  • A. A. Farooqui
    • 2
  • L. A. Horrocks
    • 2
  1. 1.Department of NeurologyOhio State UniversityColumbusUSA
  2. 2.Department of Physiological ChemistryOhio State UniversityColumbusUSA

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