Biochemical Aspects of the Regenerating Goldfish Visual System

  • Bernard W. Agranoff
  • Thomas S. Ford-Holevinski
Chapter
Part of the Advances in Neurochemistry book series (volume 22)

Abstract

Why some nerves regenerate and others do not is a question of direct relevance for investigators who wish to establish a proper treatment of traumatic injuries as well as of degenerative and developmental disorders of the nervous system. At present, knowledge is rapidly unfolding regarding the participation of intrinsic as well as extrinsic factors that have been implicated on the basis of a number of experimental models in a variety of species. An example of the dependence of regeneration on extrinsic factors is the finding that neurites from CNS neurons will grow if provided with PNS supporting cells. This can be seen following implantation of an autograft of sciatic nerve in the rat CNS (Benfey and Aguayo, 1982). Although such experiments can be used to support the hypothesis that extrinsic factors regulate regeneration, it can also be argued that neurons that regenerate following axotomy are able to do so because they possess a genetic potential that is not expressed in neurons that cannot. This concept of an intrinsic neuronal regulation of regeneration is supported by the demonstration of growth-associated proteins (GAPs; see Chapters 10 and 11) that appear in the axons of nerves that can regenerate but not in those that do not. It may eventually be proven that both extrinsic and intrinsic mechanisms play a role (Bunge et al., 1978; Bray et al., 1981), and it is likely to be the case that neuronal and nonneuronal cells interact such that each cell type induces altered metabolism in the other.

Keywords

Optic Nerve Ganglion Cell Neurite Outgrowth Retinal Ganglion Cell Axonal Transport 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Bernard W. Agranoff
    • 1
  • Thomas S. Ford-Holevinski
    • 1
  1. 1.Department of Biological Chemistry and Mental Health Research InstituteUniversity of MichiganAnn ArborUSA

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