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Mammalian Glycosyltransferases

Their Role in the Synthesis and Function of Complex Carbohydrates and Glycolipids
  • Harry Schachter
  • Saul Roseman

Abstract

The general process for the synthesis of complex carbohydrates is that of transglycosylation:
$${\text{G - O - R}}_{\text{1}} {\text{ + R}}_{\text{2}} {\text{ - OH}} \rightleftharpoons {\text{G - O - R}}_{\text{2}} {\text{ + R}}_{\text{1}} {\text{ - OH}}$$
G—O—R1 is the glycosyl donor which is usually a sugar phosphate compound such as a sugar nucleotide. R2—OH is the acceptor, which can be an alcohol, a sugar phosphate, a monosaccharide, or an oligosac-charide. The discovery of glycogen synthetase by Leloir and Cardini (1957) established the role of sugar nucleotides in complex carbohydrate assembly in vivo; phosphorylase was seen to play a catabolic role under physiologic conditions. Sugar nucleotides are, from a thermodynamic point of view, superior donors for complex carbohydrate assembly; these “high-energy” compounds are now known to be the glycosyl donors involved in glycoprotein and glycosphingolipid biosynthesis (see Part B of this chapter).

Keywords

Sialic Acid Blood Group Cholera Toxin Sugar Nucleotide Bovine Colostrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Harry Schachter
    • 1
  • Saul Roseman
    • 2
  1. 1.Department of BiochemistryHospital for Sick ChildrenTorontoCanada
  2. 2.Department of Biology and the McCollum Pratt InstituteThe Johns Hopkins UniversityBaltimoreUSA

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