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Pathogenesis of Bronchial Asthma

  • Michael H. Grieco
Chapter
Part of the Comprehensive Immunology book series (COMIMUN, volume 6)

Abstract

Bronchial asthma, a disease referred to in the Hippocratic writings, was vividly described by Aretaeus in the second century. Galen thought of asthma as the result of the accumulation of thick secretions coming down from the brain via conduits to the upper and lower respiratory tracts. The vagal nervous system and heredity were implicated as etiological factors by Eberle’s treatise on the practice of medicine published in 1830 in Philadelphia. Thereafter numerous authors thought of spasmodic asthma as the result of perverted innervation of the vagi based on experimental demonstration that stimulation of the vagus nerve produced contraction of the bronchi. These reports and observations culminated in the hypothesis of Eppinger and Hess (1915) that asthma is due to functional imbalance of the autonomic nervous system resulting from vagotonia and excessive cholinergic activity and in the local “organ vagotonia” concept of Takino (1946).

Keywords

Mast Cell Histamine Release Airway Smooth Muscle Small Airway Mast Cell Degranulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abe, K., Watanabe, N., Kumagai, M., Mouri, T., Seki, T., and Yoshinaga, K., 1967, Circulating plasma kinin in patients with bronchial asthma, Experientia 23: 626–631.CrossRefPubMedGoogle Scholar
  2. Adolphson, R. L., Abern, S. B., and Townley, R. G.N 1970, Demonstration of alpha adrenergic receptors in human respiratory smooth muscle, Clin. Res. 18: 629–633.Google Scholar
  3. Ahlquist, R. P., 1948, A study of the adrenergic receptors, Am. J. Physiol. 153: 586–606.PubMedGoogle Scholar
  4. Allen, D. H., Mathison, D. A., Wagner, P. D., Arroyave, C. M., Ploy, E., and Tan, E. M., 1977, Mediator release during methacholine-induced bronchoconstriction in asthmatic patients, 34 Annual Meeting, American Academy of Allergyn Feb. 27-Mar. 1, Abstr. 40.Google Scholar
  5. Alston, W. C., Patel, K. R., and Kerr, J. W., 1974, Response of leukocyte adenyl cyclase to isoprenaline and effect of alpha-blocking drugs in extrinsic asthma, Br. Med. J. 1: 90–93.CrossRefPubMedGoogle Scholar
  6. American Thoracic Society Committee on Diagnostic Standards for Nontuberculous Diseases, 1962, Definitions and classification of chronic bronchitis, asthma, and pulmonary emphysema, Am. Rev. Respir. Dis. 85: 762–766.Google Scholar
  7. Anand, S. C., Itkin, I. H., and Kind, L. S., 1968, Effect of influenza vaccine on methacholine (mecholyl) sensitivity in patients with asthma of known and unknown origin, J. Allergy 42: 187–92.CrossRefGoogle Scholar
  8. Anthracite, R. F., Vachon, L., and Knapp, P. H., 1971, Alpha-adrenergic receptors in the human lung, 33: 481–488.Google Scholar
  9. Apold, J., and Asknes, L., 1977, Correlation between increased bronchial responsiveness to histamine and diminished plasma cyclic adenosine monophosphate response after epinephrine in asthmatic children, J. Allergy Clin. Immunol. 59: 343–347.CrossRefPubMedGoogle Scholar
  10. Arkins, J. A., Schleuter, D. P., and Fink, J. N., 1968, The effect of corticosteroids on methacholine inhalation in symptomatic bronchial asthma, J. Allergy 41: 209–216.CrossRefPubMedGoogle Scholar
  11. Arroyave, C. M., Stevenson, D. D., and Vaughan, J. H., 1977, Plasma complement changes during bronchospasm provoked in asthmatic patients, Clin. Allergy 7: 173–180.Google Scholar
  12. Assem, E. S. K., and Turner-Warwick, M., 1976, Cytophilic antibodies in ronchopulmonary aspergilloma and cryptogenic pulmonary eosinophilia, Clin. Exp. Immunol. 26: 67–77.Google Scholar
  13. Astin, T. W., and Penman, R. W. B., 1967, Airway obstruction due to hypoxemia in patients with chronic lung disease, Am. Rev. Respir. Dis. 95: 567–577.PubMedGoogle Scholar
  14. Austen, K. F., and Orange, R. P., 1975, Bronchial asthma: The possible role of the chemical mediators of immediate hypersersivivity in the pathogenesis of subacute chronic disease, Am. Rev. Respir. Dis. 112: 423–436.PubMedGoogle Scholar
  15. Bazaral, M., Orgel, H. A., and Hamburger, R. N., 1974, Genetics of IgE and allergy: Serum IgE levels in twins, J. Allergy Clin. Immunol. 54: 288–304.CrossRefGoogle Scholar
  16. Beall, G. N., 1963, Plasma histamine concentrations in allergic diseases, J. Allergy 34: 8–16.CrossRefPubMedGoogle Scholar
  17. Beavo, J. A., Hardman, J. G., and Sutherland, E. W., 1971, Stimulation of adenosine 3’,5’monophosphate hydrolysis by guanosine 3’-5’ monophosphate, J. Biol. Chem. 246: 3841–3847.PubMedGoogle Scholar
  18. Berger, A. J., Mitchell, R. A., and Severinghaus, J. W., 1977, Regulation of respiration N. Engl. J. Med. 297 :92–97, 138–143, 194–201.Google Scholar
  19. Berkovitz, S., Millian, S. J., and Snyder, R. D., 1970, The association of viral and mycylosma infections with recurrence of wheezing in the asthmatic child Ann. Allergy 28 :43–49.Google Scholar
  20. Berman, S. Z., Mathison, D. A., Stevenson, D. D., Tan, E. M., and Vaughan, J. H., 1975, Transtracheal aspiration studies in asthmatic patients in relapse with “infective” asthma and in subjects without respiratory disease, J. Allergy Clin. Immunol. 56: 206–214.CrossRefPubMedGoogle Scholar
  21. Berry, J. B., and Brighton, W. D., 1977, Familial human short-term sensitizing (IgG S-TS) antibody Clin. Allergy 7 :401–406.Google Scholar
  22. Bhat, K. N., Arroyave, C. M., Marney, S. R., Jr., Stevenson, D. D., and Tan, E. M., 1976, Plasma histamine changes during provoked bronchospasm in asthmatic patients, J. Allergy Clin. Immunol. 58: 647–656.CrossRefPubMedGoogle Scholar
  23. Bienenstock, J., and Johnston, N., 1976, A morphologic study of rabbit bronchial lymphoid aggregate and lymphoepithelium, Lab. Invest. 35: 343–349.Google Scholar
  24. Blair, T. H., Grensberg, S. B., and Stevens, P. M., 1976, Effects of rhinovirus infection on pulmonary function of healthy human volunteers Am. Rev. Resp. Dis. 114 :95–102.Google Scholar
  25. Boat, T., and Kleinerman, J., 1975, Human respiratory tract secretions. 2. Effect of cholinergic and adrenergic agents on in vitro release of protein and mucous glycoprotein, Chest 67: 325–329.CrossRefGoogle Scholar
  26. Bogart, D. B., and Stechschulte, D. J., 1974, Release of platelet activating factor from human lung, Clin. Res. 22:652 (abstr.).Google Scholar
  27. Bouhuys, A., 1976, Experimental asthma in man and in animals, in: Bronchial Asthma: Mechanisms and Therapeutics (E. B. Weiss and M. S. Segal, eds.), pp. 457–470, Little, Brown, Boston. Breeze, R. G., and Wheeldon, E. B., 1977, The cells of the pulmonary airways, Am. Rev. Respir. Dis. 116: 705–777.Google Scholar
  28. Brocklehurst, W. E., 1958, The action of 5-hydroxytryptamine on smooth muscle, in: 5-Hydroxytryptamine (G. P. Lewis, ed.), Pergamon, New York.Google Scholar
  29. Brocklehurst, W. E., 1968, Pharmacological mediators of hypersensitivity reaction, in: Clinical Aspects of Immunology ( P. G. H. Gell and R. R. A. Coombs, eds.), Blackwell, Oxford.Google Scholar
  30. Brostoff, J., Mowbray, J. F., Kapoor, H., Hollowell, S. J., Rudolf, M., and Saunders, K. B., 1976, 80% of patients with intrinsic asthma are homozygous for HLA W6, Lancet 2: 872–873.Google Scholar
  31. Bryant, D. H., Burns, M. W., and Lazarus, L., 1975, Identification of IgG antibody as a carrier of reaginic activity in asthmatic subjects J. Allergy Clin. Immunol. 56 :417–428.Google Scholar
  32. Brown, N. E., McFadden, E. R., Jr., and Ingram, R. H., Jr., 1977, Relative contribution of large and small airways to flow limitation in normal subjects before and after atropine and isoproterenol, J. Clin. Invest. 59: 696–701.CrossRefGoogle Scholar
  33. Burnstock, G., 1970, Smooth Muscle (E. Bullbring, A. F. Brading, A. W. Jones, and T. Tometa, eds.), pp. 1–16, Williams and Wilkins, Baltimore.Google Scholar
  34. Burnstock, G., Satchell, D. L., and Smythe, A., 1972, A comparison of the excitatory and inhibitory effects of nonadrenergic, noncholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species, Br. J. Pharmacol. 46: 234–241.CrossRefPubMedGoogle Scholar
  35. Busse, W. W., 1977, Decreased granulocyte response to isoproterenol in asthma during upper respiratory infections Am. Rev. Respir. Dis. 115 :783–791.Google Scholar
  36. Busse, W. W., and Sosman, J., 1977, Decreased H2 histamine response of granulocytes of asthmatic patients J. Clin. Invest. 59:1080–1087.Google Scholar
  37. Busse, W. W., Reed, C. E., and Hoehne, J. H., 1972, II. Demonstration of ragweed antigen in airborne particules smaller than pollen J. Allergy Clin. Immunol. 50 :289–293.Google Scholar
  38. Busse, W. W., Cooper, W., Warshauer, D., Dick, E., and Albrecht, R., 1978, Altered granulocyte isoproterenol and H-2 histamine response by in vitro influenza virus, 34th Annual Meeting, American Academy of Allergy, Abstr. 68.Google Scholar
  39. Cabezas, G. A., Graf, P. D., and Nadel, J. A., 1971, Sympathetic versus parasympathetic nervous regulation of airways in dogs, J. Appl. Physiol. 51: 651–655.Google Scholar
  40. Callerame, M. L., Condemi, J. J., Ishizaka, K., Johansson, S. G. O., and Vaughan, J. H., 1971a, Immunoglobulins in bronchial tissues from patients with asthma with special reference to immunoglobulin E, J. Allergy 47: 187–194.Google Scholar
  41. Callerame, M. L., Condemi, J. J., Bohrod, M. G., and Vaughan, J. H., 1971b, Immunologic reactions of bronchial tissues in asthma, N. Engl. J. Med. 284: 459–464.CrossRefPubMedGoogle Scholar
  42. Cardell, B. S., and Pearson, R. S. B., 1959, Death in asthmatics Thorax 14 :341–346 Google Scholar
  43. Casterline, C. L., Evans, R., III, and Ward, G. W., Jr., 1976, The effect of atropine and albuterol aerosols on the human bronchial response to histamine, J. Allergy Clin. Immunol. 58: 67–613.CrossRefGoogle Scholar
  44. Cate, T. R., Roberts, J. S., Russ, M. A., and Pierce, J. A., 1973, Effects of common colds on pulmonary function, Am. Rev. Respir. Dis. 108: 858–865.Google Scholar
  45. Chan-Yeung, M., 1977, The effect of Sch 1000 and disodium cromoglycate on exercise-induced asthma, Chest 71: 320–323.CrossRefPubMedGoogle Scholar
  46. Clancy, R., and Bienenstock, J., 1974, The proliferative response of bronchus-associated lymphoid tissue after local and systemic immunization, J. Immunol. 112: 1997–2001.PubMedGoogle Scholar
  47. Cockcroft, D. W., Killian, D. N., Mellon, J. J. A., and Hargreave, F. E., 1977, Protective effect of drugs on histamine-induced asthma, Thorax 32: 429–437.CrossRefPubMedGoogle Scholar
  48. Coffey, R. G., and Middleton, E., Jr., 1973, Relrease of histamine from mast cells by lysosomal cationic proteins: Possible involvement of adenylate cyclase and adenosine triphosphatase in pharmacologic regulation, Int. Arch. Allergy 45: 593–599.CrossRefPubMedGoogle Scholar
  49. Coffey, R. G., and Middleton, E., Jr., 1974, Effects of glucocorticosteroids on the urinary excretion of cyclic AMP and electrolytes by asthmatic children, J. Allergy Clin. Immunol. 54: 41–53.CrossRefPubMedGoogle Scholar
  50. Coffey, R. G., and Middleton, E., Jr., 1975, Increased adenosine triphosphatase activity in platelets of asthmatic children, Int. Arch. Allergy Immunol. 48: 171–181.Google Scholar
  51. Coffey, R. G., Hadden, J. W., Hadden, E. M., and Middleton, E., Jr., 1971, Stimulation of ATPase by norepinephrine: An alpha-adrenergic receptor mechanisms, Fed. Proc. 30: 497 (abstr.).Google Scholar
  52. Coffey, R. G., Hadden, J. W., and Middleton, E., Jr., 1974, Increased adenosine triphosphatase in leukocytes of asthmatic children, J. Clin. Invest. 54: 138–146.Google Scholar
  53. Connell, J. T., 1971, Asthmatic deaths: Role of the mast cell, J. Am. Med. Assoc. 215:769–776. Conolly, M. E., and Greenacre, J. K., 1976, The lymphocyte beta adrenergic receptor in normal subjects and patients with bronchial asthma, J. Clin. Invest. 58: 1307–1316.Google Scholar
  54. Cooke, R. A., and Vander Veer, A., 1916, Human sensitization J. Immunol. 1 :216–226.Google Scholar
  55. Cookson, D. U., and Reed, C. E., 1963, A comparison of the effects of isoproterenol in the normal and asthmatic subject, Am. Rev. Respir. Dis. 88: 636–641.PubMedGoogle Scholar
  56. Cotton, D. J., Bleecker, E. R., Fischer, S. P., Graf, P. D., Gold, W. M., and Nadel, J. A., 1977, Rapid shallow breathing after Ascaris suum antigen inhalation: Role of vagus nerves, J. Appl. Physiol. 42: 107–111.Google Scholar
  57. Cuthbert, M. F., 1972, Prostaglandins and bronchial smooth muscle Thorax 27 :263–274.Google Scholar
  58. Davies, R. J., Butcher, B. T., O’Neil, C. E., and Salvaggio, J. E., 1977, The in vitro effect of toluene diisocyanate on lymphocyte cyclic adenosine monophosphate production by isoproterenol, prostaglandin and histamine J. Allergy Clin. Immunol. 60 :223–228.Google Scholar
  59. Dawson, W., and Tomlinson, R., 1974, Effect of cromoglycate and eicosatrienoic acid on the release of prostaglandins and SRS-A from immunologically challenged guinea pig lungs, Br. J. Pharmacol. 52: 107–112.CrossRefGoogle Scholar
  60. De Kock, M. A., Nadel, J. A., Zui, S., Colebatch, H. J. H., and Olsen, C. R., 1966, New method for perfusing bronchial arteries: Histamine bronchoconstriction and apnea, J. Appl. Physiol. 21: 185–192.Google Scholar
  61. Dolovich, M. B., Sanchis, J., and Rossman, C., 1976, Aerosol penetrance: A sensitive index of peripheral airways obstruction, J. Appl. Physiol. 40: 468–472.PubMedGoogle Scholar
  62. Drazen, J. M., and Austen, K. F., 1974a, Atropine modification of the pulmonary effects of chemical mediators in the guinea pig, J. Appl. Physiol. 38: 834–837.Google Scholar
  63. Drazen, J. M., and Austen, K. F., 1974b, Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2,, on pulmonary mechanics in the guinea pig, J. Clin. Invest. 53: 1679–1685.CrossRefPubMedGoogle Scholar
  64. Dunhill, M. S., 1960, The pathology of asthma, with special reference to changes in the bronchial mucosa, J. Clin. Pathol. 13: 27–39.CrossRefGoogle Scholar
  65. Ellefsen, P., and Tos, M., 1972, Goblet cells in human trachea: Quantitative studies of a pathological biopsy material, Arch. Otolaryngol. 95: 547–555.Google Scholar
  66. Empey, D. M., Laitinen, L. A., Jacobs, L., Gold, W. M., and Nadel, J. A., 1976, Mechanisms of bronchial hyperactivity in normal subjects after upper respiratory tract infection, Am. Rev. Respir. Dis. 113: 131–139.PubMedGoogle Scholar
  67. Eppinger, H., and Hess, L., 1915, Vagotonia: A Clinical Study in Vegetative Neurology, Nervous and Mental Disease Publishing Co., New York.Google Scholar
  68. Farr, R. S., 1970, The need to re-evaluate acetylsalicylic acid (aspirin), J. Allergy 45: 321–328.CrossRefPubMedGoogle Scholar
  69. Field, J., Allegra, J., Trautlein, J., Demers, L., Gillin, M., and Zelis, R., 1976, Measurement of plasma prostaglandins during exercise-induced bronchospasm, J. Allergy Clin. Immunol. 58: 581–585.CrossRefPubMedGoogle Scholar
  70. Fink, J. N., Moore, V. L., and Barboriak, J. J., 1975, Cell-mediated hypersensitivity in pigeon breeders, Int. Arch. Allergy Immunol. 49: 831–837.CrossRefGoogle Scholar
  71. Fish, J. E., Rosenthal, R. R., Batra, G., Menkes, H., Summer, W., Permutt, S., and Norman, P., 1976, Airway responses to methacholine in allergic and nonallergic subjects, Am. Rev. Respir. Dis. 113: 579–586.PubMedGoogle Scholar
  72. Fish, J. E., Rosenthal, R. R., Summer, W. R., Menkes, H., Norman, P. S., and Permutt, S., 1977, The effect of atropine on acute antigen-mediated airway constriction in subjects with allergic asthma, Am. Rev. Respir. Dis. 115: 371–379.PubMedGoogle Scholar
  73. Frohlich, F., 1949, Die “Helle Zellle” der Bronchialschleimhaut and ihre Beziehungen zum Problem des Chemoreceptoren, Frankfurt Z. Pathol. 60: 517–543.Google Scholar
  74. Gallin, J. I., Sandler, J. A., Clyman, R. I., Manganiello, V. C., and Vaughan, M., 1978, Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion, J. Immunol. 120: 492–496.PubMedGoogle Scholar
  75. Gerber, M. A., Paronetto, F., and Kochwa, S., 1971, Immunohistochemical localization of IgE in asthmatic lungs, Am. J. Pathol. 62: 339–349.Google Scholar
  76. Gillsepie, E., Valentine, M. D., and Lichtenstein, L. M., 1974, Cyclic AMP metabolism in asthma: Studies with leukocytes and lymphocytes, J. Allergy Clin. Immunol. 53: 27–33.CrossRefGoogle Scholar
  77. Goetzl, E. J., and Austen, K. F., 1976, Structural determinants of the eosinophil chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis, J. Exp. Med. 144: 1424.CrossRefPubMedGoogle Scholar
  78. Gold, W. M., 1977, Neurohumoral interactions in airways, Am. Rev. Respir. Dis. Suppl. 115:127–137. Gold, W. M., Kessler, G. R., and Yu, D. Y. C., 1972, Role of vagus nerve in experimental asthma in allergic dogs, J. Appl. Physiol. 33: 719–725.Google Scholar
  79. Grant, J. A., Dupree, E., and Thueson, D. 0., 1977, Complement-mediated release of histamine from human leukocytes. III. Possible regulatory role of microtubules and microfilaments, J. Allergy Clin. Immunol. 60: 306–311.Google Scholar
  80. Green, K., Hedqvist, P., and Svanborg, N., 1974, Increased plasma levels of 15-keto-13,14 dehydroprostaglandin F2c, after allergen-provoked asthma in man, Lancet 2: 1419–1422.CrossRefPubMedGoogle Scholar
  81. Grieco, M. H., and Pierson, R. N., Jr., 1970, Cardiopulmonary effects of methacholine in asthmatic and normal subjects, J. Allergy 45: 195–207.CrossRefPubMedGoogle Scholar
  82. Grieco, M. H., and Pierson, R. N., 1971, Mechanism of bronchoconstriction due to beta adrenergic blockade, J. Allergy Clin. Immunol. 48: 143–152.CrossRefPubMedGoogle Scholar
  83. Grieco, M. H., Pierson, R. N., Jr., and Pi-Sunyer, F. X., 1968, Comparison of the circulatory and metabolic effects of isoproterenol, epinephrine and methoxamine in normal and asthmatic subjects, Am. J. Med. 44: 863–872.CrossRefPubMedGoogle Scholar
  84. Griffin, J. P., Kamburoff, P. L., and Prime, P. J., 1972, Thymoxamine and airway obstruction, Lancet 1: 1288–1294.CrossRefPubMedGoogle Scholar
  85. Gross, G. N., Souhrada, J. F., and Farr, R. S., 1974, The long-term treatment of an asthmatic patient using phentolamine, Chest 66: 397–401.CrossRefPubMedGoogle Scholar
  86. Guirgis, H. M., and McNeill, R. S., 1969, The nature of the adrenergic receptors in isolated human bronchi, Thorax 24: 613–615.CrossRefPubMedGoogle Scholar
  87. Haddock, A. M., Patel, K. R., Alston, W. C., and Kerr, J. W., 1975, Response of lymphocyte guanyl cyclase to propranolol, noradrenaline, thymoxamine, and acetylcholine in extrinsic bronchial asthma, Br. Med. J. 1: 357–359.CrossRefGoogle Scholar
  88. Hage, E., Hage, J., and Juel, G., 1977, Endocrine-like cells of the pulmonary epithelium of the human adult lung, Cell. Tissue Res. 1978: 39–45.Google Scholar
  89. Hall, W. J., Douglas, R. G., Jr., and Hyde, R. W., Roth, F. K., Cross, A. S., and Speers, D. M., 1976, Pulmonary mechanics after uncomplicated influenza, Am. Rev. Respir. Dis. 113: 141–147.Google Scholar
  90. Harris, J. 0., Bice, D., and Salvaggio, J. E., 1976, Cellular and humoral bronchopulmonary immune response of rabbits immunized with thermophilic actinomyces antigen, 114: 29–43.Google Scholar
  91. Hayes, J. A., 1976, The pathology of bronchial asthma, in: Bronchial Asthma Mechanisms and Therapeutics ( E. B. Weiss and M. S. Segal, eds.), pp. 347–381, Little, Brown, Boston.Google Scholar
  92. Herxheimer, H., and Stresemann, E., 1961, The effect of bradykinin aerosol in guinea-pigs and in man, J. Physiol. (London) 158: 38.Google Scholar
  93. Hoehne, J. H., and Reed, C. E., 1971, Where is the allergic reaction in ragweed asthma ? J. Allergy Clin. Immunol. 48: 36–39.CrossRefPubMedGoogle Scholar
  94. Hoffman, D. R., and Haddad, Z. H., 1974, Diagnosis of IgE-mediated reactions to food antigens by radioimmunoassay, J. Allergy Clin. Immunol. 54: 165–173.CrossRefPubMedGoogle Scholar
  95. Hogg, J. C., Macklem, P. T., and Thurlbeck, W. M., 1968, Site and nature of airway obstruction in chronic obstructive lung disease, N. Engl. J. Med. 278: 1355–1360.CrossRefPubMedGoogle Scholar
  96. Hubscher, T., 1975, Role of the eosinophil in the allergic reactions. I. EDI- an eosinophil-derived inhibitor of histamine release, J. Immunol. 114: 1379–1384.PubMedGoogle Scholar
  97. Hudgel, D. W., Cooper, D., and Souhrada, J., 1976, Reversible restrictive lung disease simulating asthma, Ann. Intern. Med. 85: 328–332.PubMedGoogle Scholar
  98. Hyman, A. L., Spannhake, E. W., and Kadowitz, P. J., 1978, Prostaglandins and the lung, Am. Rev. Respir. Dis. 117: 111–136.PubMedGoogle Scholar
  99. Ida, S., Hooks, J. J., Siraganian, R. P., and Notkins, A. L., 1977, Enhancement of IgE-mediated histamine release from human basophils by viruses—Role of interferon, J. Exp. Med. 145: 892–898.CrossRefPubMedGoogle Scholar
  100. Ingram, R. H., Jr., Wellman, J. J., McFadden, E. R., Jr., and Mead, J., 1977, Relative contribution of large and small airways to flow limitation in normal subjects before and after atropine and isoproterenol, J. Clin. Invest. 59: 696–703.CrossRefPubMedGoogle Scholar
  101. Itkin, I. H., and Anand, S. C., 1970, The role of atropine as a mediator blocker of induced bronchial obstruction, J. Allergy 45: 178–186.CrossRefPubMedGoogle Scholar
  102. Jeffrey, P., and Reid, L., 1973, Intraepithelial nerves in normal rat airways: A quantitative electron microscopic study, J. Anat. 114: 35–42.Google Scholar
  103. Jenne, J. W., Chick, T. W., Strickland, R. D., and Wall, F. J., 1977a, A comparison of beta adrenergic function in asthma and chronic bronchitis, J. Allergy Clin. Immunol. 60: 341–356.CrossRefGoogle Scholar
  104. Jenne, J. W., Chick, T. W., Strickland, R. D., and Wall, F. J., 1977b, Subsensitivity of beta responses during treatment with a long-acting beta-2 preparation, J. Allergy Clin. Immunol. 59: 383–390.CrossRefPubMedGoogle Scholar
  105. Johanson, W. G., Jr., Pierce, A. K., and Sanford, J. P., 1969, Pulmonary function in uncomplicated influenza, Am. Rev. Respir. Dis. 100: 141–146.PubMedGoogle Scholar
  106. Johansson, S. G. 0., 1967, Raised levels of a new immunoglobulin class (IgND) in asthma, Lancet 2: 951–955.CrossRefPubMedGoogle Scholar
  107. Kaliner, M., 1976, The cholinergic nervous system and immediate hypersensitivity. I. Eccrine sweat responses in allergic patients, J. Allergy Clin. Immunol. 58: 308–315.Google Scholar
  108. Kaliner, M. A., Orange, R. P., and Austen, K. F., 1972, Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. IV. Enhancement of cholinergic and alpha adrenergic enhancement of mediator release, J. Exp. Med. 1936: 556–567.Google Scholar
  109. Kariman, K., and Lefkowitz, R. J., 1977, Decreased beta-adrenergic receptor bindings in lymphocytes from patients with bronchial asthma, Clin. Res., 503A (abstr.).Google Scholar
  110. Karr, R. M., Davies, R. J., Butcher, B. T., Lehrer, S. B., Wilson, M. R., Dharmarajan, V., and Salvaggio, J. E., 1978, Occupational asthma, J. Allergy Clin. Immunol. 61: 54–65.CrossRefPubMedGoogle Scholar
  111. Kay, A. B., and Austen, K. F., 1971, The IgE-mediated release of eosinophil chemotactic factor from human lung, J. Immunol. 107: 899–902.PubMedGoogle Scholar
  112. Kelly, M. T., and White, A., 1974, An inhibitor of histamine release from human leukocytes, J. Clin. Invest. 53: 1343–1348.CrossRefPubMedGoogle Scholar
  113. Kessler, G. F., Austin, J. H. M., Graf, P. D., Gamsu, G., and Gold, W. M., 1973, Airway constriction in experimental asthma in dogs: Tantalum bronchographic studies, J. Appl. Physiol. 35: 703–709.PubMedGoogle Scholar
  114. Kilburn, K. H., 1968, A hypothesis for pulmonary clearance and its applications, Am. Rev. Respir. Dis. 98: 449–453.PubMedGoogle Scholar
  115. Kiviloog, J., 1975, The effect of pretreatment with atropine in exercise-induced bronchoconstriction, Pediatrics. Suppl. 56: 940–941.Google Scholar
  116. Klotz, S. D., and Berstein, C., 1950, The use of dibenamine in the severe asthmatic state and related chronic pulmonary conditions, Ann. Allergy 8: 767–771.PubMedGoogle Scholar
  117. Kontou-Karakitsos, K., Salvaggio, J. E., and Mathews, K. P., 1975, Comparative nasal absorption of allergens in atopic and nonatopic subjects, J. Allergy Clin. Immunol. 55: 241–248.CrossRefPubMedGoogle Scholar
  118. Krell, R. D., Chakrin, L. W., and Wardell, J. R., Jr., 1976, The effect of cholinergic agents on a canine model of allergic asthma, J. Allergy Clin. Immunol. 58: 19–30.CrossRefPubMedGoogle Scholar
  119. Kumar, L., and Newcomb, R. W., 1970, Effect of living measles vaccine on bronchial sensitivity of asthmatic children to methacholine, J. Allergy 45: 104 (abstr.).Google Scholar
  120. Laitinen, L. A., Elkin, R. B., Empey, D. W., Jacobs, L., Mills, J., Gold, W. M., and Nadel, J. A., 1976, Changes in bronchial reactivity after administration of live attenuated influenza virus, Am. Rev. Respir. Dis. 113: 194 (abstr.).Google Scholar
  121. Lang, P., Goel, Z., and Grieco, M. H., 1978, Subsensitivity of T lymphocytes to sympathomimeticGoogle Scholar
  122. and cholinergic stimulation in bronchial asthma, J. Allergy Clin. Immunol. 61: 248–254.Google Scholar
  123. Laros, C. D., 1971, Local chemical regulation of the flow resistance in the bronchial tree and pulmonary circulation, Respiration 28: 120–128.CrossRefPubMedGoogle Scholar
  124. Lauweryns, J. M., and Goodeeris, P., 1975, Neuroepithelial bodies in the human child and adult lung, Am. Rev. Respir. Dis. 111: 469–476.PubMedGoogle Scholar
  125. Lee, T.-P., Kue, J. F., and Greengard, P., 1972, Role of muscarinic cholinergic receptors in regulation of guanosine 3’5’-cyclic monophosphate content in mammalian brain, heart muscle and intestinal smooth muscle, Proc. Natl. Acad. Sci. 69: 3287–3291.CrossRefPubMedGoogle Scholar
  126. Lefkowitz, R. J., 1976, ß-Adrenergic receptors, recognition and regulation, New Engl. J. Med. 295: 323–328.Google Scholar
  127. Lehrer, S. B., Tan, E. M., and Vaughan, J. H., 1974, Extraction and partial purification of the histamine-sensitizing factor of Bordetella pertussis, J. Immunol. 113: 18–26.PubMedGoogle Scholar
  128. Lett-Brown, M. A., and Leonard, E. J., 1977, Histamine-induced inhibition of normal basophil chemotaxis to C5a, J. Immunol. 118: 815–821.PubMedGoogle Scholar
  129. Levine, B. B., Stember, R. H., and Fotino, M., 1972, Ragweed hay fever: Genetic control and linkage to HI-A haplotypes, J. Allergy Clin. Immunol. 51: 81 (abstr.).Google Scholar
  130. Lewis, R. A., and Austen, K. F., 1977, Nonrespiratory functions of pulmonary cells: The mast cell, Fed. Proc. 36: 2676–2682.Google Scholar
  131. Lichtenstein, L. M., and Gillespie, E., 1973, Inhibition of histamine release by histamine controlled by H-2 receptor, Nature (London) 244: 287–292.CrossRefGoogle Scholar
  132. Lichtenstein, L. M., and Margolis, S., 1968, Histamine release in vitro: Inhibition by catecholamines and methylxanthines, Science 161: 902–906.CrossRefPubMedGoogle Scholar
  133. Logsdon, P. J., Middleton, E., Jr., and Coffey, R. G., 1972, Stimulation of leukocyte adenyl cyclase by hydrocortisone and isoproterenol in asthmatic and non-asthmatic subjects, J. Allergy Clin. Immunol. 50: 45–56.CrossRefPubMedGoogle Scholar
  134. Logsdon, P. J., Carnright, D. V., Middleton, E., Jr., and Coffey, R. G., 1973, The effect of phentolamine on adenylate cyclase and on isoproterenol stimulation in leukocytes from asthmatic and nonasthmatic subjects, J. Allergy Clin. Immunol. 52: 148–157.CrossRefPubMedGoogle Scholar
  135. Lumsden, T., 1923, Observations on the respiratory centres in the cat, J. Physiol. (London) 57: 153–162.Google Scholar
  136. Luparello, T. J., Leist, N., Laurie, E. J., and Sweet, P., 1970, The interaction of psychologic stimuli and pharmacologic agents on airway reactivity in asthmatic subjects, Psychosom. Med. 32: 509–515.Google Scholar
  137. Maccia, C. A., Gallagher, J. S., Ataman, G., Glueck, H. I., Brooks, S. M., and Bernstein, I. L., 1977, Platelet thrombopathy in asthmatic subjects with elevated immunoglobulin E, J. Allergy Clin. Immunol. 59: 101–108.CrossRefPubMedGoogle Scholar
  138. Mann, S. P., 1971, The innervation of mammalian bronchial smooth muscle: The localization of catecholamines and cholinesterases, Histochem. J. 3: 319–325.Google Scholar
  139. Marcelle, R., Bottin, R., and Jiechmes, J., 1968, Réactions bronchomatrices de l’homme sans après blocage des récepteurs ß adrénergiques, Acta Allérgol. 23: 11–17.Google Scholar
  140. Marsh, D. G., and Bias, W. B., 1974, Control of specific allergic response in man: HL-A associated and IgE-regulatory genes, Fed. Proc. 33: 774 (abstr.).Google Scholar
  141. Marsh, D. G., Bias, W. B., Hse, S. H., and Goodfriend, L., 1973, Association of the HL-A 7 cross-reacting group with a specific reaginic antibody response in allergic man, Science 179: 691–696.CrossRefPubMedGoogle Scholar
  142. Marsh, D. G., Bias, W. B., and Ishizaka, K., 1974, Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity, Proc. Natl. Acad. Sci. 71: 3588–3593.CrossRefPubMedGoogle Scholar
  143. Mathe, A. A., 1977, Prostaglandins and the lung in: The Prostaglandins, Vol. 3 (P. W. Ramwell, ed.), pp. 169–180, Plenum, New York.Google Scholar
  144. Mathe, A. A., and Hedqvist, P., 1975, Effect of prostaglandins F2. and E2 on airway conductance in healthy subjects and asthmatic patients, Am. Rev. Respir. Dis. 111: 313–320.PubMedGoogle Scholar
  145. Mathe, A. A., and Knapp, P. H., 1969, Decreased plasma free fatty acids and urinary epinephrine in bronchial asthma, N. Engl. J. Med. 281: 234–238.CrossRefPubMedGoogle Scholar
  146. Mathe, A. A., Aström, A., and Persson, N. A., 1971, Some bronchodilating responses of human isolated bronchi: Evidence for the existence of alpha adrenoreceptors, J. Pharm. Pharmacol. 23: 905–911.CrossRefPubMedGoogle Scholar
  147. Mathe, A. A., Hedqvist, P., Strandberg, K., and Leslie, C. A., 1977, Aspects of prostaglandin function in the lung, N. Engl. J. Med. 296:850–855, 910–914.Google Scholar
  148. Mayrhofer, G., Bazin, H., and Gowans, J. L., 1976, Nature of cells binding anti-IgE in rats immunized with Nippostrongylus brasiliensis: IgE synthesis in regional nodes and concentration in mucosal mast cells, Eur. J. Immunol. 6: 537–544.CrossRefPubMedGoogle Scholar
  149. McCarter, J. H., and Vazquez, J. J., 1966, The bronchial basement membrane in asthma, Arch. Pathol. 82: 328–336.Google Scholar
  150. McFadden, E. R., Jr., Ingram, R. H., Jr., and Haynes, R. L., 1977, Predominant site of flow limitation and mechanisms of post-exertional asthma, J. Appl. Physiol. 42: 746–752.PubMedGoogle Scholar
  151. McIntosh, K., Ellis, E. R., and Hoffman, L. S., 1973, The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children, J. Pediatr. 82: 578–582.CrossRefPubMedGoogle Scholar
  152. Middleton, E., Jr., and Finke, S. R., 1968, Metabolic response to epinephrine in asthma, J. Allergy 42: 288–299.CrossRefPubMedGoogle Scholar
  153. Mills, J. E., and Widdicombe, J. G., 1970, Role of the vagus nerve in anaphylaxis and histamine-induced bronchoconstriction in guinea pigs, Br. J. Pharmacol. 39: 724–728.CrossRefPubMedGoogle Scholar
  154. Mills, J. E., Sellick, H., and Widdicombe, J. G., 1969, Activity of lung irritant receptors in pulmonary microembolism anaphylaxis and drug-induced bronchoconstriction, J. Physiol. (London) 205: 337–341.Google Scholar
  155. Minor, T. E., Dick, E. C., De Meo, A. N., Ouellette, J. J., Cohen, M. P., and Reed, C. E., 1974, Viruses as precipitants of asthmatic attacks in children, J. Am. Med. Assoc. 227: 292–298.CrossRefGoogle Scholar
  156. Minor, T. E., Dick, E. C., Baker, J. W., Ouellette, J. J., Cohen, M., and Reed, C. E., 1976, Rhinovirus and Influenza type A infections as precipitants of asthma, Am. Rev. Respir. Dis. 113: 149–153.PubMedGoogle Scholar
  157. Mitchell, I., Inglis, H., and Simpson, H., 1976, Viral infection in wheezing bronchitis and asthma in children, Arch. Dis. Child. 15: 707–711.CrossRefGoogle Scholar
  158. Moncada, S., Gryglewski, R. J., Bunting, S., et al., 1976, A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation, Prostaglandins 12: 715–718.CrossRefPubMedGoogle Scholar
  159. Moore, V. L., Hensley, G. T., and Fink, J. N., 1975, An animal mode of hypersensitivity pneumonitis in the rabbit, J. Clin. Invest. 56: 937–944.CrossRefPubMedGoogle Scholar
  160. Morris, H. G., DeRoche, G., and Earle, M. R., 1972, Urinary excretion of epinephrine and norepinephrine in asthmatic children, J. Allergy Clin. Immunol. 50: 138–145.CrossRefPubMedGoogle Scholar
  161. Morris, H. G., DeRoche, G. C., and Caro, C. N., 1974, Response of leukocyte cyclic AMP to epinephrine stimulation in vivo and in vitro, J. Allergy Clin. Immunol. 53: 98 (abstr.).Google Scholar
  162. Morris, H. G., Rusnak, S. A., and Barzens, K., 1977, Leukocyte cyclic adenosine monophosphate in asthmatic children: Effects of adrenergic therapy, Clin. Pharmacol. Ther. 22:352–356. Nadel, J. A., 1968, Mechanisms of airway response to inhaled substances, Arch. Environ. Health 16: 171–178.Google Scholar
  163. Nadel, J. A., 1977, Autonomic control of airway smooth muscle and airway secretions, Am. Rev. Respir. Dis. Suppl. 115: 117–126.Google Scholar
  164. Nadel, J. A., Cabezas, G. A., and Austin, J. H. M., 1971, In vivo roentgenographic examination of parasympathetic innervation of small airways: Use of powdered tantalum and a fine focal spot X-ray tube, Chest Radiol. 6: 9–16.Google Scholar
  165. Nelson, H. S., Black, J. W., Branch, L. B., Pfuetze, B., Spaulding, H., Summers, R., and Wood, D., 1975, Subsensitivity to epinephrine following the administration of epinephrine and ephedrine to normal individuals, J. Allergy Clin. Immunol. 55: 299–309.Google Scholar
  166. Neshi, S., 1970, Cholinergic and adrenergic receptors at sympathetic preganglion nerve terminals, Fed. Proc. 29: 1957 (abstr.).Google Scholar
  167. Niden, A. H., 1967, Bronchiolar and large alveolar cell in pulmonary phospholipid metabolism, Science 158: 1323–1327.CrossRefPubMedGoogle Scholar
  168. Oates, J. A., Melmon, K., Sjoerdsma, A., Gillespie, L., and Mason, D. T., 1964, Release of a kinin peptide in the carcinoid syndrome, Lancet 1: 514–518.CrossRefPubMedGoogle Scholar
  169. Okazaki, T., Vervloet, D., Attallah, A., Lee, J. B., and Arbesman, C. A., 1976, Prostaglandins and asthma: The use of blood components for metabolic studies, J. Allergy Clin. Immunol. 57: 124–133.CrossRefPubMedGoogle Scholar
  170. Okazaki, T., Ilea, V. S., Rosario, N. A., Reisman, R. R., Arbesman, C. E., Lee, J. B., and Middleton, E., Jr., 1977, Regulatory role of prostaglandin E in allergic histamine release with observations on the responsiveness of basophil leukocytes and the effect of acetylsalicylic acid, J. Allergy Clin. Immunol. 60: 360–366.Google Scholar
  171. Orange, R. P., Austen, W. G., and Austen, K. R., 1971, Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. I. Modulation by agents influencing cellular levels of cyclic 3’,5’-adenosine monophosphate,.1. Exp. Med. 134: 136–145.Google Scholar
  172. Ouellette, J. J., and Reed, C. E., 1965, Increased response of asthmatic subjects to methacholine after influenza vaccine, J. Allergy 36: 558–563.CrossRefPubMedGoogle Scholar
  173. Ouellette, J. J., Chosy, J. J., and Reed, C. E., 1967, Catecholamine execretion and bronchial response to methacholine after Salmonella enteriditis endotoxin in a normal and an asthmatic subject, J. Allergy 39: 234–237.CrossRefPubMedGoogle Scholar
  174. Pantal, A. S., 1973, Vagal sensory receptors and their reflex effects, Physiol. Rev. 53:159–164. Parish, W. E., 1970, Short term anaphylactic antibodies in human sera, Lancet 2: 591–592.Google Scholar
  175. Parish, W. E., 1974, Skin sensitizing non-IgE antibodies: Association between human IgG S-TS and IgG4, Progr. Immunol. 4: 19–25.Google Scholar
  176. Parker, C. D., and Bilbo, R. E., 1965, Methacholine aerosol as a test for bronchial asthma, Arch. Intern. Med. 115: 452–455.Google Scholar
  177. Parker, C. W., and Smith, J. W., 1973, Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma, J. Clin. Invest. 52: 48–59.CrossRefPubMedGoogle Scholar
  178. Patel, K. R., 1975, Atropine, sodium cromoglycate, and thymoxamine in PGF2- induced bronchoconstriction in extrinsic asthma, Br. Med. J. 2: 360–362.CrossRefPubMedGoogle Scholar
  179. Patel, K. R., and Kerr, J. W., 1975, Effect of alpha receptor blocking drug, thymoxamine, on allergen induced bronchoconstriction in extrinsic asthma, Clin. Allergy 5: 311–316.Google Scholar
  180. Paterson, J. W., Conolly, M. E., and Davies, D. S., 1968, Isoprenaline resistance and the use of pressurized aerosols in asthma, Lancet 2: 426–431.CrossRefPubMedGoogle Scholar
  181. Patterson, R., Tornita, Y., Oh, S. H., Susyko, I. M., and Pruzansky, J. J., 1974, Respiratory mast cells and basophiloid cells. 1. Evidence that they are secreted into the bronchial lumen, morphology degeneration and histamine release, Clin. Exp. Immunol. 16: 223–229.Google Scholar
  182. Pepys, J., 1977, Clinical and therapeutic significance of patterns of allergic reactions of the lungs to extrinsic agents, Am. Rev. Respir. Dis. 116: 573–588.PubMedGoogle Scholar
  183. Pepys, J.,and Hutchcroft, B. J., 1975, Bronchial provocation tests in etiologic diagnosis and analysis of asthma, Am. Rev. Respir. Dis. 112: 829–859.Google Scholar
  184. Petersson, B. A., 1975, Induction of histamine release and desensitization in human leukocytes: IgGmediated histamine release, Scand. J. Immunol. 4: 777–784.Google Scholar
  185. Petersson, B. A., Nilsson, A., and Stalenheim, G., 1975, Induction of histamine release and desensitization in human leukocytes, J. Immunol. 114.: 1581–1584.PubMedGoogle Scholar
  186. Picken, J. J., Niewoehner, D. E., and Chester, E. H., 1972, Prolonged effects of viral infections of the upper respiratory tract upon small airways, Am. J. Med. 52: 738–746.CrossRefPubMedGoogle Scholar
  187. Poothullil, J., Umemoto, L., Dolovich, J., Hargreave, F. E., and Day, R. P., 1976, Inhibition by prednisone of late cutaneous allergic responses induced by antiserum to human IgE, J. Allergy Clin. Immunol. 57: 164–167.CrossRefPubMedGoogle Scholar
  188. Rachelefsky, G., Park, M. S., Siegel, S., Terasaki, P. I., Katz, R., and Saito, S., 1976, Strong association between B-lymphocyte group-2 specificity and asthma, Lancet 2: 1042–1044.CrossRefPubMedGoogle Scholar
  189. Reid, L. M., 1960, Measurement of the bronchial mucus gland layer: A diagnostic yardstick in chronic bronchitis, Thorax 15: 132–141.CrossRefPubMedGoogle Scholar
  190. Reid, R. T., 1970, Reaginic activity associated with immunoglobulins other than IgE, J. Immunol. 104: 935.PubMedGoogle Scholar
  191. Rhodin, J. A. G., 1966, The ciliated cell: Ultrastructure and function of the human tracheal mucosa, Am. Rev. Respir. Dis. 93: 1–11.PubMedGoogle Scholar
  192. Richardson, J. B., and Bouchard, T., 1975, Demonstration of a nonadrenergic inhibitory nervous system in the trachea of the guinea pig, J. Allergy Clin. Immunol. 56: 473–480.CrossRefPubMedGoogle Scholar
  193. Richardson, J. B., Hogg, J. C., Bouchard, T., and Hall, D. L., 1973, Localization of antigen in experimental bronchoconstriction in guinea pigs, J. Allergy Clin. Immunol. 52: 172–181.CrossRefPubMedGoogle Scholar
  194. Ruffin, R. E., Cockcroft, D. W., and Hargreave, F. E., 1978, A comparison of the protective effects of fenoterol and Sch 1000 on allergen-induced asthma, J. Allergy Clin. Immunol. 61: 42–47.CrossRefPubMedGoogle Scholar
  195. Ryan, J. W., and Ryan, U. S., 1977, Pulmonary endothelial cells, Fed. Proc. 36: 2686–2690.Google Scholar
  196. Ryo, U. Y., and Townley, R. G., 1976, Comparison of respiratory and cardiovascular effects of isoproterenol propranolol and practolol in asthmatic and normal subjects, J. Allergy Clin. Immunol. 57: 12–24.CrossRefPubMedGoogle Scholar
  197. Salvaggio, J. E., Cavenaugh, J. J. A., Lowell, F. C., and Leskowitz, S., 1964, A comparison of the immunologic responses of normal and atopic individuals to intranasally administered antigen, J. Allergy 35: 62–67.CrossRefPubMedGoogle Scholar
  198. Salvaggio, J., Phanuphak, P., Stanford, R., Bice, D., and Claman, H., 1975, Experimental production of granulomatous pneumonitis, J. Allergy Clin. Immunol. 56: 364–380.CrossRefPubMedGoogle Scholar
  199. Salvato, G., 1968, Some histological changes in chronic bronchitis and asthma, Thorax 23:168–173. Saum, W. R., and De Groat, W. C., 1972, Parasympathetic ganglion: Activation of an adrenergic inhibitory mechanism by cholinomimetic agents, Science 1975: 659–664.Google Scholar
  200. Schorlemmer, H. Y., Edwards, J. H., Davies, P., and Allison, A. C., 1977, Macrophage responses to mouldy hay dust, Micropolyspora faeni and zymosan, activators of complement by the alternate pathway, Clin. Exp. Immunol. 27: 198–204.Google Scholar
  201. Segal, M. S., and Dulfano, M. J., 1965, Glomectomy in the treatment of chronic bronchial asthma, N. Engl. J. Med. 272: 57–63.CrossRefPubMedGoogle Scholar
  202. Sen, D. K., Arora, S., Gupta, S., and Sanyal, R. K., 1974, Studies of adrenergic mechanisms in relation to histamine sensitivity in children immunized with Bordetella pertussis vaccine, J. Allergy Clin. Immunol. 54: 25–31.CrossRefPubMedGoogle Scholar
  203. Silva, D. G., and Ross, G., 1974, Ultrastructure and fluorescence histochemical studies on the innervation of the tracheobronchial muscle of normal cats and cats treated with 6-hydroxydopamine, J. Ultrastruct. Res. 47: 310–318.CrossRefPubMedGoogle Scholar
  204. Simani, A. S., Inouel, S., and Hogg, J. C., 1974, Penetration of the respiratory epithelium of guinea pigs following exposure to cigarette smoke, Lab. Invest. 31: 75–81.PubMedGoogle Scholar
  205. Simon, R. A., Stevenson, D. D., Arroyave, C. M., and Tan, E. M., 1977, The relationship of plasma histamine to the activity of bronchial asthma, J. Allergy Clin. Immunol. 60: 312–316.CrossRefPubMedGoogle Scholar
  206. Simonsson, B. G., Jacobs, F. M., and Nadel, J. A., 1967, Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease, J. Clin. Invest. 46: 1812–1818.CrossRefPubMedGoogle Scholar
  207. Simonsson, B. G., Svedmyer, N., Anderson, R., and Bergh, N. P., 1972, In vivo and in vitro studies on alpha-receptors in human airways; potentiation with bacterial endotoxins, Scand. J. Respir. Dis. 58: 227–236.Google Scholar
  208. Siraganian, R. P., and Hook, W. A., 1976, Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction, J. Immunol. 116: 639–646.PubMedGoogle Scholar
  209. Sokol, W. N., and Beall, G. N., 1975, Leukocyte epinephrine receptors of normal and asthmatic individuals, J. Allergy Clin. Immunol. 55: 310–324.CrossRefPubMedGoogle Scholar
  210. Solinger, A., Bernstein, D. L., and Glueck, H. I., 1973, The effect of epinephrine on platelet-aggregation in normal and atopic subjects, J. Allergy Clin. Immunol. 51: 29–34.CrossRefPubMedGoogle Scholar
  211. Soutar, C. A., 1976, Distribution of plasma cells and other cells containing immunoglobulin in the respiratory tract of normal man and class of immunoglobulin contained therein, Thorax 31: 158–164.CrossRefPubMedGoogle Scholar
  212. Spaulding, H. S., Jr., Nelson, A. S., and Branch, B., 1975, Altered cardiovascular and metabolic responses to epinephrine following the administration of ephedrine and terbutaline to normal men, J. Allergy Clin. Immunol. 55: 97 (abstr.).Google Scholar
  213. Spector, S., Luparello, T. J., Kopetzky, M. T., Souhrada, J., and Kinsman, R. A., 1976, Response of asthmatics to methacholine and suggestion, Am. Rev. Respir. Dis. 113: 43–50.PubMedGoogle Scholar
  214. Stevenson, D. D., Mathison, D. A., Tan, E. M., and Vaughan, J. H., 1975, Provoking factors in bronchial asthma, Arch. Intern. Med. 135: 777–783.Google Scholar
  215. Stevenson, D. D., Arroyave, C. M., Bhat, K. N., and Tan, E. M., 1976, Oral aspirin challenges in asthmatic patients: A study of plasma histamine, Clin. Allergy 6: 493–499.CrossRefPubMedGoogle Scholar
  216. Stimson, J. A. V., Hintz, D. S., Minster, A. M., and Spicer, S. S., 1977, Immunocytochemical evidence for antibody binding to mast cell granules, Exp. Mol. Pathol. 26: 85–94.CrossRefGoogle Scholar
  217. Strauss, R. H., Ingram, R. H., Jr., and McFadden, E. R., Jr., 1977, A critical assessment of the roles of circulating hydrogen ion and lactate in the production of exercise-induced asthma, J. Clin. Invest. 60: 658–664.CrossRefPubMedGoogle Scholar
  218. Sturgess, J., and Reed, L., 1972, An organ culture study of the effect of drugs on the secretory activity of the human bronchial submucosal gland, Clin. Sci., 43: 533–541.PubMedGoogle Scholar
  219. Sutherland, E. W., Robison, G. A., and Butcher, R. W., 1968, Some aspects of the biological role of adenosine 3’,5’-monophosphate (cyclic AMP), Circulation 37: 299–306.CrossRefGoogle Scholar
  220. Svedmyr, N. L. V., Larsson, S. A., and Thiringer, G. K., 1976, Development of “resistance” in beta-adrenergic receptors of asthmatic patients, Chest 69: 479–484.CrossRefPubMedGoogle Scholar
  221. Szczeklik, A., Gryglewski, R. J., and Czerneawska-Mysik, G., 1975, Relationship of inhibiton of prostaglandin in biosyntheses by analgesics to asthma attacks in aspirin-sensitive patients, Br. Med. J. 1: 67–73.CrossRefPubMedGoogle Scholar
  222. Szczeklik, A., Gryglewski, R. J., and Czerniawska-Mysik, G., 1977, Asthmatic attacks induced in aspirin-sensitive patients by dicloferae and naproxen, Br. Med. J. 2: 321.CrossRefGoogle Scholar
  223. Szentivanyi, A., and Filipp, G., 1965, Anaphylaxis and the nervous system. Part II, Ann. Allergy 16: 143–151.Google Scholar
  224. Szentivanyi, A., Fishel, C. W., and Talmage, D. W., 1963, Adrenalin mediation of histamine and serotinin hyperglycemia in pertussis sensitized mice, J. Infect. Dis. 113: 86–98.CrossRefPubMedGoogle Scholar
  225. Takino, M., 1946, Findings in bronchial asthma, Sogiogaku (Japan) 3: 456–468.Google Scholar
  226. Takino, M., and Takino, Y., 1968, Indication for glomectomy and postoperative treatment of asthma, Tokuku J. Exp. Med. 94: 257–273.Google Scholar
  227. Tauber, A. E., Kaliner, M., Stechschulte, D. J., and Austen, K. F., 1973, Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine, J. Immunol. 111: 27–32.PubMedGoogle Scholar
  228. Terr, A. I., and Bentz, J. D., 1965, Skin sensitizing antibodies in serum sickness, J. Allergy 36: 433–445.CrossRefPubMedGoogle Scholar
  229. Townley, R. G., McGeady, S., and Bewtra, A., 1976, The effect of beta adrenergic blockade on bronchial sensitivity to acetyl-beta-methacholine in normal and allergic rhinitis subjects, J. Allergy Clin. Immunol. 57: 358–366.CrossRefPubMedGoogle Scholar
  230. Ts’ao, C. H., Patterson, R., McKenna, J. M., and Suszko, I. M., 1977, Ultrastructural identification of mast cells obtained from human bronchial lumens, J. Allergy Clin. Immunol. 59: 320–326.CrossRefPubMedGoogle Scholar
  231. Unväs, B., 1968, Histamine release in allergic conditions, in: Allergology (B. Rose, M. Richater, A. Sehon, and A. W. Frankland, eds.), pp. 127–141, Excerpta Medica Foundation, Amsterdam. Vidruk, E. H., Hahn, H. L., Nadel, J. A., and Sampson, S. R., 1976, Mechanism of stimulation of rapidly adapting receptors of histamine in dog lung, Fed. Proc. 35:841 (abstr.).Google Scholar
  232. Vijay, H. M., and Perelmutter, L., 1977, Inhibition of reagin-mediated PCA reactions in monkeys and histamine release from human leukocytes by human IgG, subclass, Int. Arch. Allergy Appl. Immunol. 53: 78–87.CrossRefPubMedGoogle Scholar
  233. Walker, I. C., 1918, A clinical study of 400 patients with bronchial asthma, Boston Med. Surg. J. 1979: 288–294.Google Scholar
  234. Wallace, D., and Grieco, M. H., 1976, Double-blind cross-over study of cromolyn sodium inhibition of exercise-induced bronchospasm in adults, Ann. Allergy 37: 153–163.PubMedGoogle Scholar
  235. Webster, M. E., Horakova, Z., Beaver, M. A., Takahashi, H., and Newball, H. H., 1974, Release of arginine esterase and histamine from human lung passively sensitized with ragweed antibody, Fed. Proc. 33: 761 (abstr.).Google Scholar
  236. Weiss, E. B., and Patwardhan, A. W., 1977, The responses to lidocaine in bronchial asthma, Chest 72: 429–438.PubMedGoogle Scholar
  237. Wellmann, J. J., McFadden, E. R., Jr., and Ingram, R. H., Jr., 1976, Density-dependence of maximal expiratory flow rates before and after bronchodilators in patients with obstructive airways disease, Clin. Sci. Mol. Med. 51: 133–138.Google Scholar
  238. Widdicombe, J. C., 1963, Regulation of tracheobronchial smooth muscle, Physiol. Rev. 43:1–37. Widdicombe, J. C., 1974, Reflex control of breathing, in: Respiratory Physiology: MTP International Review of Science, Ser. 1, Vol. 2 (J. G. Widdicombe, ed.), pp. 273–301, Butterworth, London. Woolcock, A. J., Macklem, P. T., and Hogg, J. C., 1969, Influence of autonomic nervous system on airway resistance and elastic recoil, J. Appl. Physiol. 26: 814–821.Google Scholar
  239. Yu, D. Y. C., Galant, S. P., and Gold, W. M., 1972, The role of the parasympathetic nervous system in human asthma: Inhibition of antigen-induced bronchoconstriction by atropine sulfate, J. Appl. Physiol. 32: 823–828.PubMedGoogle Scholar
  240. Zaid, G., and Beall, G. N., 1966, Bronchial response to beta-adrenergic blockade, New Engl. J. Med. 275: 580–584.CrossRefPubMedGoogle Scholar
  241. Zimmerman, I., Islam, M. S., and Ulmer, W. T., 1976, Effect of unilateral vagus blockade on antigen-induced airway obstruction, Respiration 33: 359–365.CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Michael H. Grieco
    • 1
    • 2
  1. 1.R. A. Cooke Institute of Allergy and the Allergy, Clinical Immunology, and Infectious Disease Division, Medical ServiceThe Roosevelt HospitalNew YorkUSA
  2. 2.Department of Clinical MedicineColumbia University College of Physicians and SurgeonsNew YorkUSA

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