A Reappraisal of the Mechanisms of Hypocholesterolemic Action of Therapeutic Agents

  • H. S. Sodhi
  • B. J. Kudchodkar
  • C. Clifford
  • N. Borhani
  • D. T. Mason
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 109)

Abstract

The most commonly used methods to study the mechanisms of hypocholesterolemic action of therapeutic agents generally determine the turnover of total (exchangeable) cholesterol pools in the body. This approach is based on the view that whatever increases the total load of cholesterol in the body will increase the levels of plasma cholesterol, and vice versa. Despite the importance of this assumption it has never been tested, and there is no evidence to indicate that it is valid under all conditions.

Keywords

Plasma Cholesterol Cholesterol Synthesis Plasma Lipoprotein Endogenous Cholesterol Tissue Pool 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. S. Sodhi
    • 1
  • B. J. Kudchodkar
    • 1
  • C. Clifford
    • 1
  • N. Borhani
    • 1
  • D. T. Mason
    • 1
  1. 1.School of Medicine DavisUniversity of CaliforniaUSA

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