Heparin pp 365-374 | Cite as

Surface-Bonded Heparin

  • R. D. Falb
  • R. I. Leininger
  • G. Grode
  • J. Crowley
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 52)

Abstract

The first report of surface-attached heparin was by Gott and coworkers in 1965 (8). In this work, heparin was attached through formation of a complex with a quaternary ammonium salt that was adsorbed on graphite. The discovery of the thromboresistant properties of heparinized surfaces was inadvertent: the original intent of the work was to evaluate graphite. The graphite surface was treated with a quaternary ammonium salt to sterilize it, and the surface was rinsed in heparin as a simple precautionary measure. Gott et al. showed that the marked thromboresistance of the graphite- benzalkonium-heparin (GBH) surface was due to the presence of heparin This held promise of enabling the use of foreign sufaces in contact with blood without systemic anticoagulation. However, in practice, the GBH coating could not be applied to flexible materials; thus, its use was limited.

Keywords

Natural Rubber Silicone Rubber Platelet Rich Plasma Quaternary Ammonium Salt Covalent Attachment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • R. D. Falb
    • 1
  • R. I. Leininger
    • 1
  • G. Grode
    • 1
  • J. Crowley
    • 1
  1. 1.Battelle Memorial LaboratoriesColumbusUSA

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