Control of Renin Secretion pp 109-116 | Cite as
Area Postrema — Angiotensin-Sensitive Site in Brain
Abstract
It is well known that angiotensin has a direct effect on peripheral arterial walls and also acts on brain directly or indirectly and accordingly elevates the blood pressure. Dickinson and Yu (1) have demonstrated a pressor response to low concentrations of angiotensin infused into the vertebral artery of rabbits. Similar effects have been reported in dogs by Scroop and Lowe (2) and in man by Ueda et al. (3). This study was designed to clarify the central site of action of angiotensin II by examining the effect of local injection of angiotensin and the evoked potential of neurons after local and vertebral artery injection of angiotensin in cats.
Keywords
Brain Stem Vertebral Artery Pressor Response Medulla Oblongata Blood Pressure ResponsePreview
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References
- 1.Dickinson, C.J. and Yu R.: Mechanisms involved in the progressive pressor response to very small amounts of angiotensin in conscious rabbits. Circulation Res. 21: 157, 1967.PubMedGoogle Scholar
- 2.Scroop, G.C. and Lowe, R.D.: Central pressor effect of angiotensin mediated by the parasympathetic nervous system. Nature 220: 1331, 1968.PubMedCrossRefGoogle Scholar
- 3.Ueda, H., Uchida, Y. et al.: Centrally mediated vasopressor effect of angiotensin II in man. Jap. Heart J. 10: 243, 1969.PubMedCrossRefGoogle Scholar
- 4.Wislocki, G.B. and Putnam, T.J.: Further observations on the anatomy and physiology of the areae postremae. Anatomical Rec. 27: 151, 1924.CrossRefGoogle Scholar
- 5.Wang, S.C. and Borison, H.L.: A new concept of organization of the central emetic mechanism: recent studies on the sites of action of apomorphine, copper sulfate and cardiac glycosides. Gastroenterology 22: 1, 1952.PubMedGoogle Scholar
- 6.Borison, H.L. and Brizzee, K.R.: Morphology of emetic chemoreceptor trigger zone in cat medulla oblongata. Proc. Soc. Exptl. Biol. Med. 77: 38, 1951.Google Scholar
- 7.Koella, W.P. and Czicman, J.: Mechanism of EEG synchronizing action of serotonin. Am. J. Physiol. 211: 926, 1966.PubMedGoogle Scholar
- 8.Katayama, S., Ueda, H. et al.: Angiotensin and catecholamine sensitivity of area postrema. J. Physiol. Soc. Jap. 31: 451, 1969.Google Scholar
- 9.Ueda, H.: Renin-angiotensin system and central nervous system. Proceedings of 5th European Congress of Cardiology, pp. 246–252, 1968.Google Scholar
- 10.Ueda, H.: Angiotensin-sensitive site in brain. (President’s speech) J. Jp. Soc. Int. Med. 58: 1, 1969.CrossRefGoogle Scholar
- 11.Ueda, H., Katayama, S., et al.: Angiotensin-sensitive neuron in medulla oblongata. Jap. J. Med. 9: 164, 1970.Google Scholar
- 12.Ueda, H.: Renin release by catecholamine and angiotensin-sensitive site in brain stem. Presented at the Meeting of the International Society of Hypertension in Oxford on September 4, 1970.Google Scholar
- 13.Joy, M.D. and Lowe, R.D.: The site of cardiovascular action of angiotensin II in the brain. Clin. Sci. 39: 327, 1970.PubMedGoogle Scholar