DNA Synthesis pp 347-366 | Cite as

Some Aspects of DNA Strand Separation

  • James C. Wang
Chapter
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 17)

Abstract

Ever since the double helix structure was first proposed for DNA, the problem of strand separation during replication has attracted much attention. When I was asked by the organizers of this meeting to give a general survey on the physical chemistry of DNA, I decided to focus my discussions on strand separation. At the molecular level however, even the simplest in vitro DNA replication system is rather complicated, and little quantitative information is available. Therefore, the discussions to follow are qualitative and conceptual in nature.

Keywords

Free Energy Change Standard Free Energy Change Helical Turn Strand Separation Unpaired Basis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Abdel-Monem, M., Dürwald, H. and Hoffman-Berling, H. (1976) Eur. J. Biochem. 65: 441PubMedCrossRefGoogle Scholar
  2. 2.
    Abdel-Monem, M., Lauppe, H.-F., Kartenbeck, J., Dürwald, H. and Hoffmann-Berling, H. (1977a). J. Mol. Biol. 110: 667PubMedCrossRefGoogle Scholar
  3. 3.
    Abdel-Monem, M., Chanal, M-C. and Hoffmann-Berling, H. (1977b) Eur. J. Biochem.Google Scholar
  4. 4.
    Abdel-Monem, M., Dürwald, H. and Hoffmann-Berling, H. (1977c) Eur. J. Biochem.Google Scholar
  5. 5.
    Abdel-Monem, M. and Hoffmann-Berling, H. (1976) Eur. J. Biochem. 65: 431PubMedCrossRefGoogle Scholar
  6. 6.
    Baase, W.A. and Wang, J.C. (1974) Biochemistry 13: 4299PubMedCrossRefGoogle Scholar
  7. 7.
    Baba, Y. and Kagemoto, A. (1974) Biopolymers 13: 339PubMedCrossRefGoogle Scholar
  8. 8.
    Bauer, W.R., Ressner, E.C., Kates, J. and Patzke, J.V. (1977) Proc. Natl. Acad. Sci. USA 74: 1841PubMedCrossRefGoogle Scholar
  9. 9.
    Bauer, W.R. and Vinograd, J. (1970) J. Mol. Biol. 47: 419PubMedCrossRefGoogle Scholar
  10. 10.
    Beard, P., Morrow, J.F. and Berg, P. (1973) J. Virol. 12: 1303PubMedGoogle Scholar
  11. 11.
    Botchan, P., Wang, J.C. and Echols, H. (1973) Proc. Natl. Acad. Sci. USA 70: 3077PubMedCrossRefGoogle Scholar
  12. 12.
    Cairns, J. (1963a) J. Mol. Biol. 6: 208PubMedCrossRefGoogle Scholar
  13. 13.
    Cairns, J. (1963b) Cold Spring Harbor Symp. Quant. Biol. 28: 43CrossRefGoogle Scholar
  14. 14.
    Cairns, J. and Davern, C.I. (1967) J. Cell Physiol. 70: 1–65CrossRefGoogle Scholar
  15. 15.
    Champoux, J.J. (1976) Proc. Natl. Acad. Sci. USA 73: 8488CrossRefGoogle Scholar
  16. 16.
    Champoux, J.J. and Dulbecco, R. (1972) Proc. Natl. Acad. Sci. USA 69: 143PubMedCrossRefGoogle Scholar
  17. 17.
    Christiansen, C. and Baldwin, R.L. (1977) J. Mol. Biol.Google Scholar
  18. 18.
    Davidson, N. (1972) J. Mol. Biol. 66: 307PubMedCrossRefGoogle Scholar
  19. 19.
    Delbrück, M. and Stent, G.S. (1957) In: The Chemical Basis of Heredity (W.D. McElroy and B. Glass, eds.) The Johns Hopkins Press, Baltimore, pp 699Google Scholar
  20. 20.
    Delius, H., Mantell, N.J. and Alberts, B. (1972) J. Mol. Biol. 67: 341PubMedCrossRefGoogle Scholar
  21. 21.
    Depew, R.E., Liu, L.F. and Wang, J.C. (1976) Fed.Proc. Amer. Soc. Exp. Biol. 35: 1493Google Scholar
  22. 22.
    Depew, R.E. and Wang, J.C. (1975) Proc. Natl. Acad. Sci. USA 72: 4280CrossRefGoogle Scholar
  23. 23.
    Friedman, E.A. and Smith, H.O. (1973) Nature New Biol. 241: 54PubMedCrossRefGoogle Scholar
  24. 24.
    Gefter, M.L. (1975) Ann. Rev. Biochem. 44: 45PubMedCrossRefGoogle Scholar
  25. 25.
    Gefter, M.L., Molineux, I.J., Pauli, A. and Sherman, L. (1976) In: DNA Synthesis and Its Regulation. (M. Goulian and P. Hanawalt, eds.) W.A. Benjamin Inc., Menlow Park, Calif. p2Google Scholar
  26. 26.
    Gellert, M Mizuuchi, K., O’Dea, M.H. and Nash, H.A. (1976a) Proc. Natl. Acad. Sci. USA 73: 3872PubMedCrossRefGoogle Scholar
  27. 27.
    Gellert, M., O’Dea, M.H., Itoh, T. and Tomizawa, J. (1976b) Proc. Natl. Acad. Sci. USA 73: 4474PubMedCrossRefGoogle Scholar
  28. 28.
    Heijneker, H.L., Ellens, D.J., Tjeerde, R.H., Glickman, B., van Dorp, V., and Pouwels, P.H. (1973) Mol. Gen. Genet. 124: 83PubMedCrossRefGoogle Scholar
  29. 29.
    Holloman, W.K., Wiegand, R., Hoessli, C. and Radding, C.M. (1975) Proc. Natl. Acad. Sci. USA 72: 2394PubMedCrossRefGoogle Scholar
  30. 30.
    Hsieh, T.-S. and Wang, J.C. (1975) Biochemistry 14: 527PubMedCrossRefGoogle Scholar
  31. 31.
    Huberman, J.A., Kornberg, A. and Alberts, B.M. (1971) J. Mol. Biol. 62: 39PubMedCrossRefGoogle Scholar
  32. 32.
    Hurwitz, J. and Wickner, S. (1974) Proc. Nat. Acad. Sci. USA 71: 6PubMedCrossRefGoogle Scholar
  33. 33.
    Ikeda, J., Yudelevich, W. and Hurwitz, J. (1976) Proc. Natl. Acad. Sci. USA 73: 2669PubMedCrossRefGoogle Scholar
  34. 34.
    Kato, A.C., Bartok, K., Fraser, M.J. and Denhardt, D.T. (1973) Biochim. Biophys. Acta 308: 68PubMedGoogle Scholar
  35. 35.
    Keller, W. (1975a) Proc. Natl. Acad. Sci. USA 72: 2550PubMedCrossRefGoogle Scholar
  36. 36.
    Keller, W. (1975b) Proc. Natl. Acad. Sci. USA 72: 4876PubMedCrossRefGoogle Scholar
  37. 37.
    Kelly, R.B., Cozzarelli, N.R., Deutscher, M.P., Lehman, I.R. and Kornberg, A. (1970). J. Biol. Chem. 245: 39PubMedGoogle Scholar
  38. 38.
    Klump, H. and Ackermann, T. (1971) Biopolymers 10: 513PubMedCrossRefGoogle Scholar
  39. 39.
    Kolodner, R. and Richardson, C.C. (1977) Proc. Natl. Acad. Sci. USA 74: 1525PubMedCrossRefGoogle Scholar
  40. 40.
    Kung, V.W. and Wang, J.C. (1977) J. Biol. Chem.Google Scholar
  41. 41.
    Liu, L.F., Depew, R.E. and Wang, J.C. (1976) J. Mol. Biol. 106: 439PubMedCrossRefGoogle Scholar
  42. 42.
    Liu, L.F. and Wang, J.C. (1976) In: DNA Synthesis and Its Regulation (M. Goulian and P. Hanawalt, eds.) W.A. Benjamin, Inc., Menlo Park, Calif. p38Google Scholar
  43. 43.
    Livingston, D.M., Hinckle, D.C. and Richardson, C.C. (1974) J. Biol. Chem. 250: 461Google Scholar
  44. 44.
    MacKay, V. and Linn, S. (1974) J. Biol. Chem. 249: 4286PubMedGoogle Scholar
  45. 45.
    MacKay, V. and Linn, S. (1976) J. Biol. Chem. 251: 3716PubMedGoogle Scholar
  46. 46.
    Marvin, D.A. and Hohn, B. (1969) Bacteriol. Rev. 33: 172PubMedGoogle Scholar
  47. 47.
    Masamune, Y. and Richardson, C.C. (1971) J. Biol. Chem. 246: 2692PubMedGoogle Scholar
  48. 48.
    Mizuuchi, K. and Nash, H.A. (1976) Proc. Natl. Acad. Sci. USA 73: 3524PubMedCrossRefGoogle Scholar
  49. 49.
    Nossal, N.G. (1974) J. Biol. Chem., 249: 5668PubMedGoogle Scholar
  50. 50.
    Privalov, P.L. and Ptitsyn, O.B. (1969) Biopolymers 8: 559CrossRefGoogle Scholar
  51. 51.
    Pulleyblank, D.E. and Morgan, A.R. (1975) Biochemistry, 23: 5205CrossRefGoogle Scholar
  52. 52.
    Pulleyblank, D.E., Shure, M., Tang, D., Vinograd, J. and Vosberg, H. P. (1975) Proc. Natl. Acad. Sci. USA 72: 4280PubMedCrossRefGoogle Scholar
  53. 53.
    Richet, E. and Kohiyama, M. (1976) J. Biol. Chem. 251: 808PubMedGoogle Scholar
  54. 54.
    Ruyechan, W.T. and Wetmur, J.G. (1975) Biochemistry 14: 5529PubMedCrossRefGoogle Scholar
  55. 55.
    Ruyechan, W.T. and Wetmur, J.G. (1976) Biochemistry 15: 5057PubMedCrossRefGoogle Scholar
  56. 56.
    Schildkraut, C.L., Richardson, C.C. and Kornberg, A. (1964) J. Mol. Biol. 9: 24PubMedCrossRefGoogle Scholar
  57. 57.
    Scott, J.F., Eisenberg, S., Bertsch, L.L. and Kornberg, A. (1977) Proc. Natl. Acad. Sci. USA 74: 193PubMedCrossRefGoogle Scholar
  58. 58.
    Sherman, L.A. and Gefter, M.L. (1976) J. Mol. Biol. 103: 61PubMedCrossRefGoogle Scholar
  59. 59.
    Sigal, N., Delius, H., Kornberg, T., Gefter, M.L. and Alberts, B. (1972) Proc. Natl. Acad. Sci. USA 69: 3537PubMedCrossRefGoogle Scholar
  60. 60.
    Shiao, D.D.F. and Sturtevant, J.M. (1973) Biopolymers 12: 1829PubMedCrossRefGoogle Scholar
  61. 61.
    Tinoco, I. Jr.,.Borer, P.N., Dengler, B., Levine, M.D., Uhlenbeck, O.C., Crothers, D.M. and Gralla, J. (1973) Nature New Biol. 246: 40PubMedGoogle Scholar
  62. 62.
    Vinograd, J. and Lebowitz, J. (1966) J. Gen. Physiol. 49: 103PubMedCrossRefGoogle Scholar
  63. 63.
    Vosberg, H.-P. and Vinograd, J. (1976) In: DNA Synthesis and Its Regulation (M. Goulian and P. Hanawalt, eds.) W.A. Benjamin, Inc., Menlo Park, Calif. p94Google Scholar
  64. 64.
    Wang, J.C. (1971) J. Mol. Biol. 55: 523PubMedCrossRefGoogle Scholar
  65. 65.
    Wang, J.C. (1973) In: DNA Synthesis in Vitro. (R.D. Wells and R.B. Inman, eds), University Park Press, Baltimore, Md, p153Google Scholar
  66. 66.
    Wang, J.C. (1974) J. Mol. Biol. 87: 797PubMedCrossRefGoogle Scholar
  67. 67.
    Wang, J.C., Barkley, M.D. and Bourgeois, S. (1974) Nature, 251: 249CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • James C. Wang
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyHarvard UniversityCambridgeUSA

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