The Effect of Aspartame Consumption on Migraine Headache: Preliminary Results

  • Shirley M. Koehler


Almost all dietetic products now contain aspartame, a sweetener consisting of phenylalanine and aspartic acid. Recently, three pilot studies have proposed that the addition of products containing aspartame to the diets of migraine headache sufferers may produce a significant increase in the frequency of their migraines. The present study was a controlled thirteen-week, double-blind, randomized cross-over study comparing the effect of aspartame to that of a matched placebo on the frequency and intensity of migraine headache. The results of this study indicated that the ingestion of aspartame by migraineurs caused a significant increase in headache frequency for some subjects. The possible biochemical bases of these findings and their implications for research are discussed.


Aspartic Acid Migraine Headache Headache Frequency Tame Group Dietary Phenylalanine 
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  1. Adams, H.E., Feuerstein, M., and Fowler, J.L. (1980). Migraine headache: review of parameters, etiology, and intervention. Psychol. Bull. 87:2.a.CrossRefGoogle Scholar
  2. Ad Hoc Committee on Classification of Headache (1962). Classification of headache. J. Am. Med. Assoc. 179:127–128.Google Scholar
  3. Andrasik, F., Blanchard, E.B., Arena, J.G., Saunders, N.L., and Barron, K.D. (1982). Psychophysiology of recurrent headache. Behav. Ther. 13:407–429.CrossRefGoogle Scholar
  4. Blanchard, E.B., and Andrasik, F. (1982). Psychological assessment and treatment of headache: recent developments and emerging issues. J. Consult. and Clin. Psychol. 50:859–879.CrossRefGoogle Scholar
  5. Boullin, D.J. (ed.). (1978). Serotonin in mental abnormalities. New York: John Wiley & Sons.Google Scholar
  6. Dexter, J.D. (1983). Biochemical pathophysiology of migraine. Neurol. Clin. 1:527–531.Google Scholar
  7. Gibson, C.J., Deikel, S.M., Young, S.N., and Binik, Y.M. (1982). Behavioral and biochemical effects of tryptophan, tyrosine, and phenylalanine. Psychopharma-cology 76:118–121.CrossRefGoogle Scholar
  8. Harper, A.E. (1983). Phenylalanine metabolism. In Stegink, L.O., and Filer, L.J. (eds.), Aspartame: physiology and biochemistry. New York: Marcel Dekker, pp. 77–102.Google Scholar
  9. Johns, D.R. (1986). Migraine provoked by aspartame. N. Engl. J. Med. 315:456.PubMedGoogle Scholar
  10. Kewman, D., and Roberts, A.H. (1980). Skin temperature biofeedback and migraine headaches: A double-blind study. Biofeedback and Self-Regulation, 48:327–344.CrossRefGoogle Scholar
  11. Koehler, S.M. (1987). The effect of dietetic products containing phenylalanine on migraine headache. Paper presented at the Florida Psychological Association, Orlando, June.Google Scholar
  12. Koehler, S.M., and Hartje, J.C. (1985). Migraine headache and phenylalanine. Paper presented at the Society of Behavioral Medicine, New Orleans, March 30.Google Scholar
  13. Murray, J.B. (1981). Psychophysiological aspects of migraine headaches. Psychol. Rep. 48: 139–162.PubMedCrossRefGoogle Scholar
  14. Stegink, L.D., and Filer, L.J. (eds.). (1983). Aspartame: physiology and biochemistry. New York: Marcel Dekker.Google Scholar
  15. Wurtman, R.J., and Wurtman, J.J. (eds.). (1979). Nutrition and the brain, Vol. 3. New York: Raven Press.Google Scholar
  16. Yates, A.J. (1980). Biofeedback and the modification of behavior. New York: Plenum.Google Scholar

Copyright information

© Birkhäuser Boston 1988

Authors and Affiliations

  • Shirley M. Koehler
    • 1
  1. 1.Department of Clinical PsychologyUniversity of FloridaGainesvilleUSA

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