Our aim in this chapter will be to develop a prototype hypothesis of evolutionary adaptation which we hope not only helps us to surmount the difficulties of rabbit idiotypy, but also provides a better rationale for the adaptive process. In this journey, we must be conscious of those factors which speed up or slow down the natural attrition rate of scientific hypotheses. At least four criteria can be identified: (a) coherence, (b) simplicity and number of assumptions, (c) explanatory and predictive power and, in addition, (d) the hypothesis must possess a clear plan for its refutation (Popper 1972).
KeywordsGerm Cell Somatic Mutation Mutant Clone Somatic Gene Reverse Translation
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