Advertisement

Inhibitory Effects of Chlorogenic Acid, Reserpine, Polyprenoic Acid (E-5166), or Coffee on Hepatocarcinogenesis in Rats and Hamsters

  • Takuji Tanaka
  • Akiyoshi Nishikawa
  • Hiroto Shima
  • Shigeyuki Sugie
  • Tokuro Shinoda
  • Naoki Yoshimi
  • Hitoshi Iwata
  • Hideki Mori
Chapter
Part of the Basic Life Sciences book series (BLSC, volume 52)

Abstract

Four different experiments were performed in order to examine the modifying effects of chlorogenic acid (CA), reserpine, polyprenoic acid (E-5166), and coffee on chemical carcinogenesis in rats or hamsters. Experiment 1: The numbers of hyperplastic liver cell foci and the incidence of colon tumors in male and female Syrian golden hamsters given a single intraveneous injection of methylazoxymethanol (MAM) acetate and then fed the diet containing 0.025% CA for 24 wk were significantly lower than those of hamsters given MAM acetate alone. Experiment 2: The incidence of altered hepatocellular foci in female ACI/N rats given N-2-fluorenylacetamide (FAA, 0.02% in diet) for 10 wk and reserpine (weekly subcutaneous injections, 1 μg/g body weight) during or after (17 wk) FAA exposure was significantly lower than that of rats given FAA alone. Experiment 3: The number of hepatocellular foci in male ACI/N rats given 0.02% FAA diet for 13 wk and E-5166 by gavage (40 mg/kg body weight, 3 times/wk) for 16 wk after the end of FAA exposure was significantly smaller than that in rats given FAA diet alone. Experiment 4: Incidences of liver tumors and hepatocellular foci of rats given concurrent dietary administration of aminopyrine (0.01%) and sodium nitrite (0.1%) and coffee solution as a drinking water for 630 da were significantly lower than those of rats given aminopyrine and sodium nitrite. Thus, the tested compounds had inhibitory effects on chemical carcinogenesis in liver or colon.

Keywords

Chlorogenic Acid Sodium Nitrite Syrian Golden Hamster Chemical Carcinogenesis Green Coffee Bean 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Birnbaum, L., T. Sapp, and J. Moore (1976) Effects of reserpine, epidermal growth factor, and cyclic nucleotide modulator on epidermal mitosis. J. Invest. Dermatol. 66:313–318.PubMedCrossRefGoogle Scholar
  2. 2.
    Bollag, W. (1974) Therapeutic effect of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur. J. Cancer 10:731–737.PubMedGoogle Scholar
  3. 3.
    Challis, B.C., and C.D. Bartlett (1975) Possible cocarcinogenic effects of coffee constituents. Nature 254:532–533.PubMedCrossRefGoogle Scholar
  4. 4.
    Das, M., D.R. Bickers, and H. Mukhtar (1984) Plant phenols as in vitro inhibition of glutathione S-transferase(s). Biochem. Biophys. Res. Commun. 127:427–433.CrossRefGoogle Scholar
  5. 5.
    Emminger, A., and U. Mohr (1982) Tumours of the oral cavity, cheek pouch, salivary glands, oesophagus, stomach and intestines. In Pathology of Tumours in Laboratory Animals. Vol. III: Tumours of the Hamster, V.S. Turusov, ed. IARC, Lyon, pp. 45–68.Google Scholar
  6. 6.
    Hayase, F., and H. Kato (1984) Antioxidative compounds of sweet potatoes. J. Nutri. Sci. Vitaminol. 30:37–46.CrossRefGoogle Scholar
  7. 7.
    Heinonen, O.P., S. Shapiro, L. Touminen, and M.I. Turunen (1974) Reserpine use in relation to breast cancer. Lancet 2:675–677.PubMedCrossRefGoogle Scholar
  8. 8.
    Lam, L.K.T., V.L. Sparnins, and L.W. Wattenberg (1982) Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activitj’^ in the mouse. Cancer Res. 42:1193–1198.PubMedGoogle Scholar
  9. 9.
    Lasca, P. (1983) Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced neoplasia in mice. Carcinogenesis 4:1651–1653.CrossRefGoogle Scholar
  10. 10.
    Lewis, P.D., A.J. Patel, G. Bendek, and R. Balasz (1977) Effect of reserpine on cell proliferation in the developing rat brain: A quantitative histological study. Brain Res. 129:1229–1308.CrossRefGoogle Scholar
  11. 11.
    Login, I.S., A.M. Judd, M.J. Cronin, T. Yamamoto, and R.M. Macleod (1985) Reserpine is a calcium channel antagonist in normal and GH3 rat pituitary cells. Am. J. Physiol. 252:E15–19.Google Scholar
  12. 12.
    Lupulescu, A. (1984) Reserpine and carcinogenesis: Inhibition of carcinoma formation in mice. J. Natl. Cancer Inst. 71:57–62.Google Scholar
  13. 13.
    Mori, H., and I. Hirono (1977) Effect of coffee on carcinogenicity of cycasin. Br. J. Cancer 35:369–371.PubMedCrossRefGoogle Scholar
  14. 14.
    Muto, Y., and H. Moriwaki (1984) Antitumor activity of vitamin A and its derivatives. J. Natl. Cancer Inst. 73:1389–1393.PubMedGoogle Scholar
  15. 15.
    Muto, Y., H. Moriwaki, and M. Omori (1981) In vitro binding affinity of novel synthetic polyprenoid (polyprenoic acids) to cellular retinoid-binding proteins. Gann 72:974–977.PubMedGoogle Scholar
  16. 16.
    Ross, R.K., A. Paganini-Hill, M.D. Krilo, V.R. Gerkins, B.E. Henderson, and M.C. Pike (1984) Effects of reserpine on prolactin levels and incidence of breast cancer in postmenopausal women. Cancer Res. 44:3106–3108.PubMedGoogle Scholar
  17. 17.
    Schroder, E.W., and P.H. Black (1980) Retinoids: Tumor preventers or tumor enhancers? J. Natl. Cancer Inst. 65:671–674.PubMedGoogle Scholar
  18. 18.
    Snowdon, D.A., and R.L. Phillips (1984) Coffee consumption and risk of fatal cancers. Am. J. Publ. Health 74:820–823.CrossRefGoogle Scholar
  19. 19.
    Sondenheimer, E. (1964) Chlorogenic acids and related depsides. Bot. Rev. 30:677–712.Google Scholar
  20. 20.
    Sporn, M.B., and D.L. Newton (1979) Chemoprevention of cancer with retinoids. Fed. Proc. 38:2528–2534.PubMedGoogle Scholar
  21. 21.
    Stewart, H.L., G.M. Williams, C.H. Keysser, L.S. Lombard, and R.J. Montali (1980) Histologie typing of liver tumors of the rat. J. Natl. Cancer Inst. 64:177–206.Google Scholar
  22. 22.
    Stich, H.F., M.P. Rosin, C.H. Wu, and W.D. Powrie (1981) A comparative genotoxicity study of chlorogenic acid (3-O-caffeloquinic acid). Mutat. Res. 90:201–212.PubMedCrossRefGoogle Scholar
  23. 23.
    Stizel, R.E. (1977) The biological fate of reserpine. Pharmacol. Rev. 28:179–205.Google Scholar
  24. 24.
    Ward, J.M. (1982) Background data and variations in tumor rates of control in rats and mice. Prog. Exp. Tumor Res. 26:241–258.Google Scholar
  25. 25.
    Wattenberg, L. (1981) Inhibition of chemical carcinogenesis. In Cancer: Achievements, Challenges, and Prospects for the 1980’s, J.H. Burchenal, ed. Grune and Stratton, New York, pp. 517–539.Google Scholar
  26. 26.
    Wattenberg, L.W. (1985) Chemoprevention of cancer. Cancer Res. 45:1–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Welch, C.W., and J. Meites (1970) Effects of reserpine on development of 7,12-dimethylbenzanthracene-induced mammary tumors in female rats. Experientia 26:1133–1134.CrossRefGoogle Scholar
  28. 28.
    Wu, J.M. (1982) The influence of reserpine on nitrogen metabolizing enzymes in chick liver. Biochim. Biophys. Acta 715:57–62.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Takuji Tanaka
    • 1
  • Akiyoshi Nishikawa
    • 1
  • Hiroto Shima
    • 1
  • Shigeyuki Sugie
    • 1
  • Tokuro Shinoda
    • 1
  • Naoki Yoshimi
    • 1
  • Hitoshi Iwata
    • 1
  • Hideki Mori
    • 1
  1. 1.Department of PathologyGifu University School of MedicineGifu City 500Japan

Personalised recommendations