Characterization of Viral Proteins Synthesized in 229E Infected Cells and Effect(s) of Inhibition of Glycosylation and Glycoprotein Transport

  • M. C. Kemp
  • J. C. Hierholzer
  • A. Harrison
  • J. S. Burks
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


Coronaviruses were classified as a distinct group of viruses in 1968 (1) and four members of this group are recognized as human respiratory pathogens: These include B814 (2), the first human coronavirus (HCV) isolated 229E (3), OC-43 (4) and 692 (5), identified by immunoelectromicroscopy only. In addition to the respiratory pathogens, two coronaviruses have been isolated while working with brain tissue from multiple sclerosis patients (6). These viruses cross-react antigenically with OC-43 but neither of these viruses have been implicated in respiratory disease.


Multiple Sclerosis Patient 229E Protein Infectious Bronchitis Virus Virus Glycoprotein Avian Infectious Bronchitis Virus 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. C. Kemp
    • 1
    • 2
    • 3
  • J. C. Hierholzer
    • 4
  • A. Harrison
    • 4
  • J. S. Burks
    • 1
    • 2
    • 3
  1. 1.Center for Neurological DiseasesRocky Mountain Multiple Sclerosis CenterUSA
  2. 2.Veterans Administration Medical CenterUSA
  3. 3.University of Colorado School of MedicineDenverUSA
  4. 4.Division of Viral DiseasesCenters for Disease ControlAtlantaUSA

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