Interactions of Porcine Enteric Coronavirus TGEV with Macrophages and Lymphocytes

  • H. Laude
  • B. Charley
  • C. La Bonnardiere
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


Enterocytes covering the microvilli of small intestine are the only target cell of transmissible gastroenteritis (TGEV) that have been characterized until now. Such a tropism has been shown to explain the severe intestinal disorders affecting infected animals. However, several authors mentioned isolation of TGEV from respiratory tract (1, 2, 3), and the possibility of extra-intestinal sites of replication was strenghtened by recent studies on the systemic interferon (IFN) response of newborn piglets infected by wild or cell-adapted strains (H. Laude & C. La Bonnardière, to be published).


Infected Animal Newborn Piglet Systemic Interferon Extensive Cell Death Virus Input 
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    Kemeny et al., Cornell, vet. 65, 352 (1975).Google Scholar
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    Furuuchi et atl, Vet. Microbiol. 3, 169 (1978/9).CrossRefGoogle Scholar
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    La Bonnardière and Laude, Inf. Immun. 32, 28 (1981).Google Scholar
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    Charley et al., Ann. Virol 134E, 119 (1983).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. Laude
    • 1
  • B. Charley
    • 1
  • C. La Bonnardiere
    • 1
  1. 1.Station de Recherches de Virologie et d’ImmunologieI.N.R.A.Thiverval-GrignonFrance

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