Interactions of Porcine Enteric Coronavirus TGEV with Macrophages and Lymphocytes
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Enterocytes covering the microvilli of small intestine are the only target cell of transmissible gastroenteritis (TGEV) that have been characterized until now. Such a tropism has been shown to explain the severe intestinal disorders affecting infected animals. However, several authors mentioned isolation of TGEV from respiratory tract (1, 2, 3), and the possibility of extra-intestinal sites of replication was strenghtened by recent studies on the systemic interferon (IFN) response of newborn piglets infected by wild or cell-adapted strains (H. Laude & C. La Bonnardière, to be published).