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Biology of Coronaviruses 1983

  • Volker ter Meulen
Chapter
  • 446 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)

Abstract

At the first international Symposion of coronaviruses held in Würzburg in 1980, studies on the biology of coronaviruses were mainly concerned with two subjects: coronavirus persistent infections in tissue cultures and the description of different disease models, in a variety of hosts, with the particular emphasise on subacute or chronic conditions. Much of the discussion centered around the possible mechanisms of persistence and the pathogenic factors playing a role in the development of the different disease types. However, due to the lack of basic information on the molecular biology of coronaviruses the majority of studies reported three years ago were of a more descriptive nature, and in the animal studies immunological and genetic aspects were mainly analysed. In the intervening period, although surprisingly little virological information has been obtained on coronavirus persistent infections in vitro and in vivo, the animal work has been concentrated on two virus groups, namely the murine and feline coronaviruses. Obviously, the involvement of multiple organs in different diseases associated with infections of the two virus groups has turned out to be the most interesting basis for the study of virus-cell and virus-host interactions and the analyses of viral and host factors involved in the development of different disease processes.

Keywords

Basic Myelin Protein Persistent Infection Experimental Allergic Encephalomyelitis Virus Group Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Weiner, L.P., R.T. Johnson, R.M. Herndon. Viral infections and demyelinating diseases. N. Engl. J. Med. 288: 1103–1110 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    Paterson, P.Y. Transfer of allergic encephalomyelitis in rats by means of lymphnode cells. J. Exp. Med. 111: 119–136 (1960).PubMedCrossRefGoogle Scholar
  3. 3.
    Dal Canto, M.C., Rabinowitz, S.G. and T.C. Johnson. Virus-induced demyelination. J. Neurol. Sci. 42: 155–168 (1979).CrossRefGoogle Scholar
  4. 4.
    ter Meulen, V. and M.J. Carter. Morbillivirus persistent infections in animals and man. In: “Virus persistence” (B.W.J. Mahy, A.C. Minson and G.K. Darby, eds). Cambridge University Press 97–132 (1982).Google Scholar
  5. 5.
    Carter, M.J., Willcocks, M.M. and V. ter Meulen. Defective translation of measles virus matrix protein in a SSPE line. Nature, in press.Google Scholar
  6. 6.
    Wege, H., Koga, M., Wege H. and V. ter Meulen. JHM infection in rats as a model for acute and subacute demyelinating disease. In: “Biochemistry and Biology of Coronaviruses” (V. ter Meulen, S. Siddell, H. Wege, eds). Adv. Exp. Med. Biol. 142: 327–340 (1981).PubMedGoogle Scholar
  7. 7.
    Watanabe, R., Wege, H. and V. ter Meulen. Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis. Nature, in press.Google Scholar
  8. 8.
    Gonatas, N.K. and J.C. Howard. Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T-cells. Science 212: 672–675 (1974).Google Scholar
  9. 9.
    Horzinek, M.C. and A.D. Osterhaus. The virology and pathogenesis of feline infectious peritonitis. Arch. Virol. 59: 1–15 (1979).PubMedCrossRefGoogle Scholar
  10. 10.
    ter Meulen, V. and S.G. Siddell. Virus infections of the nervous system: molecular, biological and pathogenetic considerations. In: “The Molecular Basis of Neuropathology” (A.N. Davison and R.H.S. Thompson, eds), Edward Arnold Publ. 150–187 (1981).Google Scholar
  11. 11.
    Oldstone, M.B.A., Holmstoen, J. and R.M. Weese. Alterations of acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus. J. Cell Physiol. 91: 459–472 (1977).PubMedCrossRefGoogle Scholar
  12. 12.
    Halbach, M. and K. Koschel. Impairment of hormone dependent signal transfer by chronic SSPE virus infection. J. gen. Virol. 42: 615–619 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    Koschel, K. and M. Halbach. Rabies virus infection selectively impairs membrane receptor functions in neuronal model cells. J. gen. Virol. 42: 627–632 (1979).PubMedCrossRefGoogle Scholar
  14. 14.
    Barrett, P.N. and K. Koschel. Effect of antibody-induced modulation of measles (SSPE) virus membrane proteins on ß-adrenergic receptor-mediated adenylate cyclase activity. Virology. 127: in press.Google Scholar
  15. 15.
    Woodruff, J.F. and J.J. Woodruff. The effect of viral infections on the function of the immune system. In: “Viral Immunology and Immunopathology” (A.L. Notkins, ed), Academic Press, New York, San Francisco, London 393–418 (1975).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Volker ter Meulen
    • 1
  1. 1.Institute of Virology and ImmunobiologyUniversity of WürzburgWürzburgGermany

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