Methods of Nucleoside Synthesis

  • Helmut Vorbrüggen
Chapter
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 26)

Abstract

It seems now most probable that nucleosides and amino acids were among the first organic compounds formed at the start of evolution in the very early stages of the history of our planet earth. These prebiotic conditions were imitated by Orgel and coworkers who heated guanine and adenine (Scheme 1) with ribose and sea water (which contains the Lewis acid MgCl2 as catalyst) and obtained ca. 3% of natural β-guanosine as well as 2.3% of natural β-adenosine besides comparable yields of the unnatural α-nucleosides in which the base in 1- position is located α (that means below the plane of the ribose).

Keywords

Purine Nucleoside Central Valley Pyrimidine Nucleoside Trifluoromethanesulfonic Acid Heterocyclic Base 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Helmut Vorbrüggen
    • 1
  1. 1.Research Laboratories of Schering AGBerlin - BergkamenGermany

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