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Test Systems for Evaluating the Antiviral Activity of Nucleoside Analogues

  • Robert W. Sidwell
Chapter
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 26)

Abstract

Several challenges confront the investigator involved in determining if a particular nucleoside analog has significant antiviral activity. These include, first, selecting an initial test system which will utilize the relatively small amounts of the new chemical usually made available to him. A second problem is to express the antiviral results obtained in a readily understandable, quantitative manner. Finally, and of major importance, is the challenge of selecting those test systems which will accurately predict the antiviral efficacy of a new substance to the human situation. Normally the answers to these challenges are not found in a single, all-encompassing test, but rather are resolved in stepwise fashion beginning with a simple in vitro screening test and then moving into appropriate predictive animal systems.

Keywords

Respiratory Syncytial Virus Test Compound Antiviral Activity Infectious Bronchitis Virus Rift Valley Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Robert W. Sidwell
    • 1
  1. 1.Utah State UniversityLoganUSA

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