Tissue Hypoxia and Ischemia pp 143-150 | Cite as
The Sensing of Oxygen Tension in the Pulmonary Circulation
Chapter
Abstract
It now seems settled that acute hypoxia elicits pulmonary vasoconstriction and that the predominant site of constriction is the small muscular pulmonary artery1–3. What remains to be resolved is how this vasoconstriction comes about4.
Keywords
Vascular Smooth Muscle Pulmonary Circulation Acute Hypoxia Lung Mast Cell Alveolar Hypoxia
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References
- 1.Von Euler US, Liljestrand G: Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12:301–320, 1946.CrossRefGoogle Scholar
- 2.Fishman AP: Dynamics of the pulmonary circulation. In Hamilton WF, Dow P (Editors): Handbook of Physiology, Section 2, Circulation, vol 2. Washington, American Physiological Society, 1963, pp 1667–1743Google Scholar
- 3.Bergofsky EH: Mechanisms underlying vasomotor regulation of regional pulmonary blood flow in normal and disease states. Am J Med 57:378–394, 1974.PubMedCrossRefGoogle Scholar
- 4.Fishman AP: Hypoxia on the pulmonary circulation. Circ Res 38:221–231, 1976.PubMedCrossRefGoogle Scholar
- 5.Szidon JP, Fishman AP: Autonomic control of the pulmonary circulation. In Fishman AP, Hecht HH (Editors): The Pulmonary Circulation and Interstitial Space. Chicago, University of Chicago Press, 1969, pp 239–268Google Scholar
- 6.Bergofsky EH, Holtzman S: A study of the mechanisms involved in the pulmonary arterial pressor response to hypoxia. Circ Res 20:506–519, 1967.PubMedCrossRefGoogle Scholar
- 7.Torrance RW: The idea of a chemoreceptor. In Fishman AP, Hecht HH (Editors): The Pulmonary Circulation and Interstitial Space. Chicago, University of Chicago Press, 1969, pp 223–237Google Scholar
- 8.Somlyo AP, Somlyo AV: Vascular smooth muscle. II. Pharmacology of normal and hypertensive vessels. Pharmacol Rev 22:249–353, 1970.PubMedGoogle Scholar
- 9.Detar R, Bohr DF: Oxygen and vascular smooth muscle contraction. Am J Physiol 214:241–244, 1968.PubMedGoogle Scholar
- 10.Detar R, Bohr DF: Contractile responses of isolated vascular smooth muscle during prolonged exposure to anoxia. Am J Physiol 222:1269–1277, 1972.PubMedGoogle Scholar
- 11.Kay JM, Grover RF: Lung mast cells and hypoxic pulmonary hypertension. Prog Respir Res 9:157–164, 1975.Google Scholar
- 12.Lloyd TC Jr: Role of nerve pathways in the hypoxic vasoconstriction of lung. J Appl Physiol 21:1351–1355, 1966.PubMedGoogle Scholar
- 13.Hauge A: Conditions governing the pressor response to ventilation hypoxia in isolated perfused rat lungs. Acta Physiol Scand 72:33–44, 1968.PubMedCrossRefGoogle Scholar
- 14.Daly I de B, Michel CC, Ramsay DJ, Waaler BA: Conditions governing the pulmonary vascular response to ventilation hypoxia and hypoxaemia in the dog. J Physiol (Lond) 196:351–379, 1968.Google Scholar
- 15.Hauge A: Hypoxia and pulmonary vascular resistance: the relative effects of pulmonary arterial and alveolar PO2. Acta Physiol Scand 76:121–130, 1969.PubMedCrossRefGoogle Scholar
- 16.Hauge A, Staub NC: Prevention of hypoxic vasoconstriction in cat lung by histamine-releasing agent 48/80. J Appl Physiol 26:693–699, 1969.PubMedGoogle Scholar
- 17.Silove ED, Simcha AJ: Histamine-induced pulmonary vasodilatation in the calf; relationship to hypoxia. J Appl Physiol 35:830–836, 1973.PubMedGoogle Scholar
- 18.Said SI, Voshida T, Kitamura S, Vreim G: Pulmonary alveolar hypoxia: release of prostaglandins and other humoral mediators. Science 185:1181–1183, 1974.PubMedCrossRefGoogle Scholar
- 19.Vaage J, Hauge A: Prostaglandins and the pulmonary vasoconstrictor response to alveolar hypoxia. Science 189:899–900, 1975.PubMedCrossRefGoogle Scholar
- 20.Harvey RM, Enson Y, Betti R, Lewis ML, Rochester DF, Ferrer MI: Further observations on the effect of hydrogen ion on the pulmonary circulation. Circulation 35:1019–1027, 1967.PubMedCrossRefGoogle Scholar
- 21.Barer GW, McCurrie JR: Pulmonary vasomotor responses in the cat: the effect and interrelationship of drugs, hypoxia and hypercapnia. Q J Exp Physiol 54:156–172, 1969.Google Scholar
- 22.McMurtry IF, Reeves JT, Grover RF: Inhibition by verapamil of pulmonary vasoconstrictive response to alveolar hypoxia. Physiologist 17:285, 1974.Google Scholar
- 23.Souhrada JF, Dickey DW: Effect of substrate on hypoxic response of pulmonary artery. J Appl Physiol 40:533–538, 1976.PubMedGoogle Scholar
Copyright information
© Plenum Press, New York 1977