Massive Migration of Thymic Lymphocytes to Peyer’s Patches in Neonatal Mice

  • D. D. Joel
  • M. W. Hess
  • H. Cottier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 12)


Although migration of cells from the thymus to intestinal lymphoid tissues has been demonstrated in young animals (l–3), the magnitude of this process remains to be clarified, particularly during the early development of these tissues. Neonatal mice are useful experimental animals in which to study this problem. The Peyer’s patches of newborn mice are poorly developed at birth and contain only a small number of lymphoid cells (4), however, within 2 or 3 days after birth, the number of lymphoid cells increases markedly. Kinetic studies suggest that during this same developmental period there is an extensive emigration of thymic lymphoid cells (5–7). Systemic labeling data in newborn mice have provided evidence for a substantial immigration of lymphocytes into Peyer’s patches (8). These observations focus on the question of whether the gut associated lymphoid tissue in mice is a “primary” lymphoid organ as was proposed for the bursa of Fabricius in birds (9,10,11) or a “secondary” organ whose immunological development is, at least in part, thymus-dependent.


Label Index Lymphoid Cell Neonatal Mouse Newborn Mouse Thymic Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    G.J.V. Nossal, Ann. N.Y. Acad. Sci., 120:171, 1964.PubMedCrossRefGoogle Scholar
  2. 2.
    T.J. Linna, Blood, 31:727, 1968.PubMedGoogle Scholar
  3. 3.
    R.J. Iorio, A.D. Chanana, E.P. Cronkite and D.D. Joel, Cell Tissue Kinet., 3:161, 1970.PubMedGoogle Scholar
  4. 4.
    J.J. Miller, Lab. Invest., 21:484, 1969.PubMedGoogle Scholar
  5. 5.
    H. Cottier, Med. Hyg., 23:794, 1965.Google Scholar
  6. 6.
    M.W, Hess, R.D. Stoner and H. Cottier, Nature, 215: 426, 1967.PubMedCrossRefGoogle Scholar
  7. 7.
    W.D. Michalke, M.W. Hess, H. Riedvyl, R.D. Stoner and H. Cottier, Blood, 33:541, 1969.PubMedGoogle Scholar
  8. 8.
    J. Köbberling, Z. Zellforsch., 68:631, 1965.PubMedCrossRefGoogle Scholar
  9. 9.
    N.L. Warner, A. Szenberg and F.M. Burnet, J. exp. Biol. med. Sci., 40:373, 1962.CrossRefGoogle Scholar
  10. 10.
    O.K. Archer, B.W. Papermaster and R.A. Good, in: H.A. Good and A.E. Gabrielsen, Eds., The Thymus in Immunobiology, p. 414. New York: Hoeber-Harper, 1964.Google Scholar
  11. 11.
    K.E. Fichtelius, Exp. Cell Res., 46:231, 1967.PubMedCrossRefGoogle Scholar
  12. 12.
    M.D. Cooper, D.Y. Perey, A.E. Gabrielsen, D.E.R. Sutherland, M.F. McKneally and R.A. Good, Int. Arch. Allergy, 33:65, 1968.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • D. D. Joel
    • 1
    • 2
  • M. W. Hess
    • 1
    • 2
  • H. Cottier
    • 1
    • 2
  1. 1.Department of PathologyUniversity of BernSwitzerland
  2. 2.Medical Research CenterBrookhaven National LaboratoryUpton, L.I.USA

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