The Detection of Chemical Mutagens with Enteric Bacteria

  • Bruce N. Ames


Mutagens alter DNA. As the DNA of all organisms has the same double helical structure and the same four nucleotides, any organism may be used as an indicator system for mutagens. Bacteria have numerous advantages for the detection of mutagens, and we discuss these and describe various methods and strains. We also discuss the validity of the bacterial tests and their pertinence to human mutagenesis and carcinogenesis.


Petri Plate Enteric Bacterium Nitrogen Mustard Chemical Mutagen Nitrate Reductase Gene 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Bruce N. Ames
    • 1
  1. 1.Biochemistry DepartmentUniversity of CaliforniaBerkeleyUSA

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