Comparative Studies on the Structures of Conjugated Bilirubin-IXα and Changes in Cholestasis

  • K. P. M. Heirwegh
  • G. P. Van Hees
  • N. Blanckaert
  • J. Fevery
  • F. Compernolle
Chapter
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 7)

Abstract

It is classically admitted that the major bile pigment resulting from heme catabolism in mammals is bilirubin-IXα (Lathe, 1972; Gray et al., 1972). The IIIα- and XIIIα-isomers that could arise from bilirubin-IXα by dipyrrole exchange occurring in aqueous solution at about neutral pH (McDonagh and Assisi, 1972) could not be detected in bile from man, cat, dog and rat (McDonagh and Assisi, 1972; Kuenzle, 1970a; Jansen, 1974; Heirwegh et al., 1975). Small amounts of non-α isomers such as bilirubin-IXβ have been found in bile from dog and pig (Petryka, 1966; O’Carra and Colleran, 1970; Tipton and Gray, 1971), but only a few species were examined. According to a recent screening study bilirubin-IXβ and/or -IXδ is widely distributed in the animal kingdom, and even the IXγ-isomer has been detected in some species (our unpublished work).

Keywords

Glucuronic Acid Unpublished Work Bile Pigment Human Bile Normal Bile 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • K. P. M. Heirwegh
    • 1
  • G. P. Van Hees
    • 1
  • N. Blanckaert
    • 1
  • J. Fevery
    • 1
  • F. Compernolle
    • 1
  1. 1.Rega InstituutKatholieke Universiteit te LeuvenLeuvenBelgium

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