Nucleus and Cytoplasm: Supply and Demand

What Underlies the Flow of Genetic Information?
  • Anatoly V. Lichtenstein
  • Mikhail M. Zaboykin
  • Valery L. Mojseev
  • Vladimir S. Shapot
Chapter

Abstract

The main problem to be discussed in this chapter pertains to the interrelationship of the nucleus and the cytoplasm in the control of gene expression in eukaryotes. The presence of the nuclear envelope in eukaryotic cells results in the separation of transcription from translation in space and time. Hence, a number of questions arise as to the role of each of the cellular compartments in protein synthesis. For example, does the nucleus itself have total control over this process, with the cytoplasm acting merely to execute the orders issued from the nucleus? In other words, is the nuclear “supply” (via regulation at the transcriptional level) sufficient to specify qualitatively the spectrum of proteins to be synthesized in the cell and to regulate their rates of synthesis, or does cytoplasmic “demand” for certain messengers also play a role in this process?

Keywords

Nuclear Envelope Globin Gene Erythroid Cell Globin mRNA Histone Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Anatoly V. Lichtenstein
    • 1
  • Mikhail M. Zaboykin
    • 1
  • Valery L. Mojseev
    • 1
  • Vladimir S. Shapot
    • 1
  1. 1.Department of BiochemistryOncological Scientific Center of the Academy of Medical SciencesMoscowUSSR

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