Electronic Design of the Patch Clamp
The paper by Hamill et al. (1981) has already given an overview of the design of a patch clamp and other apparatus for single-channel recording. This chapter will consider some aspects of the electronic circuitry in greater detail, the main topic being the design of low-noise, wide-bandwidth current-measuring amplifiers. Under good patch-recording conditions, the tight seal (gigaseal) and patch membrane have such a low intrinsic noise level that the movement of a few hundred elementary charges should be detectable. The engineering challenge is to preserve this low noise level in the electronic circuitry.
KeywordsNoise Source Patch Clamp Drain Current Current Noise Voltage Noise
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