Genetic Analysis of Morphine Effects: Activity, Analgesia, Tolerance and Sensitization

  • Louis Shuster
Chapter

Abstract

The question of individual variability in response to narcotic drugs is of major importance in the clinical evaluation of analgesic agents. Lasagna & Beecher (1954) found that 30 to 35% of several groups of post-operative patients did not experience any pain relief after the double blind administration of morphine sulfate, 10 mg per 70 kg. Even when the dose was raised to 15 mg, 25% of the patients reported no analgesia.

Keywords

Recombinant Inbred Line Recombinant Inbred Physical Dependence Opiate Receptor Recombinant Inbred Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. BARAN, A., SHUSTER, L., ELEFTHERIOU, B. E.,& BAILEY, D. W., Opiate receptors and analgesic response in mice: basis for genetic differences Brain Res. in press.Google Scholar
  2. BEECHER, H. K., 1959, Measurement of subjective responses: Quanti-tative effects of drugs. Oxford University Press, New York.Google Scholar
  3. BRASE, D. A., TSENG, L. F., LOH, H. H. WAY, E. L., 1974, Cholinergic modification of naloxone-induced jumping in morphine-dependent mice. Eur. J. Pharmacol. 26: 1.PubMedCrossRefGoogle Scholar
  4. D’AMOUR, F. F.& SMITH, D. L., 1941, A method for determining loss of pain sensation. J. Pharmacol. Ex2.Ther. 72: 74.Google Scholar
  5. EBEL, A., HERMETET, J. C.& MANDEL, P., 1973, Comparative study of acetylcholinesterase and choline-acetyltransferase activity in the brain of DBA and C57 mice. Nature New Biology 242: 56.PubMedGoogle Scholar
  6. EDDY, N. B.& LEIMBACH, D., 1953, Synthetic analgesics. II Dithienylbutenyl-and dithienylbutylamines. J .Pharmacol.fm.Ther. 107: 385.Google Scholar
  7. EIDELBERG, E.& ERSPAMER, R., 1974, Genetic factors modulating the actions of morphine in mice. Abstracts of the Fourth Annual Meeting, Society for Neuroscience p. 199.Google Scholar
  8. ERIKSSON, K. &KIIANMAA, K., 1971, Genetic analysis of susceptibility to morphine addiction in inbred mice. Ann. Med. Exp. Biol. Fenn. 49: 73.PubMedGoogle Scholar
  9. GEBHART, G. F.& MITCHELL, C. L., 1973, Strain differences in the analgesic response to morphine as measured on the hot plate. Arch.Int.Pharmacodyn. Ther. 201: 128.PubMedGoogle Scholar
  10. GOLDSTEIN, A.& SHEEHAN, P., 1969, Tolerance to opiod narcotics. I. Tolerance to the running fit caused by levorphanol in the mouse. J. PharmacolExp Ther. 169: 175.PubMedGoogle Scholar
  11. HANO, K., KANETO, H.,& KAKUNOGA, T., 1963, Pharmacological studies on analgesics. 5. Development of physical dependence in morphinized mice. Japanese J. Pharmacol. 13: 207.Google Scholar
  12. IWAMOTO, E. R., HOW, I. K.& WAY, E. L., 1973, Elevation of brain dopamine during naloxone-precipitated withdrawal in morphine dependent mice and rats. J. Pharmacol. Exp. Ther. 187: 558.Google Scholar
  13. KARCZMAR, A. G.& SCHUDDER, C. L., 1967, Behavioral responses to drugs and brain catecholamine levels in mice of different strains and genera. Fed. Proc. 26: 1180.Google Scholar
  14. KEMPF, E., GREILSAMER, J., MACK, G.,& MANDEL, P., 1974, Correlation of behavioral difference in three strains of mice with differences in brain amines. Nature 247: 483.PubMedCrossRefGoogle Scholar
  15. KESSLER, S., CIARANELLO, R. D., SHIRE, J. G. M.& BARCHAS, J. D., Genetic variation in catecholamine-synthesizing enzyme activities. Proc.Nat. Acad. Sci. (U.S.) 69: 2448.Google Scholar
  16. KUHAR, M. J., PERT, C. B.& SNYDER, S. H., 1973, Regional distribution of opiate receptor binding in monkey and human brain. Nature (London) 245: 447.Google Scholar
  17. LASAGNA, L.& BEECHER, H. K., 1954, The optimal dose of morphine. J.Am.Med. Assoc. 156: 230.Google Scholar
  18. LASAGNA, L., VON FELSINGER, J. M.,& BEECHER, H. K., 1955, Drug-induced mood changes in man. I. Observations on healthy sub-jects, chronically ill patients, and post-addicts. J. Am. Med. Assoc. 157: 1006.Google Scholar
  19. LOWNEY, L. I., SCHULTZ, K., LOWERY, P. J.,& GOLDSTEIN, A., 1974, Partial purification of an opiate receptor from mouse brain. Science 183: 749.PubMedCrossRefGoogle Scholar
  20. MAAS, J. W., 1962, Neurochemical differences between two strains of mice. Science 137: 621.PubMedCrossRefGoogle Scholar
  21. MAAS, J. W., 1963, Neurochemical differences between two strains of mice. Nature 197: 255.PubMedCrossRefGoogle Scholar
  22. MAGGIOLO, C.& HUIDOBRO, K., 1961, Administration of pellets of morphine to mice-abstinence syndrome. Acta Physiol. Latino-amer. 11: 70.Google Scholar
  23. MARSHALL, I.& WEINSTOCK, M., 1971, A quantitative method for assessing one symptom of the withdrawal syndrome in mice after chronic morphine administration. Nature 234: 223.Google Scholar
  24. MARUYAMA, Y., HAYASHI, G., SMITS, S. E.,& TAKEMORI, A. E., 1971, Studies on the relationship between 5-hydroxytryptamine turn-over and brain tolerance and physical dependence in mice. J. Pharmacol. Exp. Ther. 718: 20.Google Scholar
  25. MILLER, L. C., 1948, A critique of analgesic testing methods. Ann. N. Y. Acad. Sci. 51: 34.Google Scholar
  26. MILLER, J. M.& COCHIN, J., 1974, The effect of continued morphine administration on motor activity in the mouse. The Pharmacologist 16: 248.Google Scholar
  27. NICHOLS, J. R.& HSIAO, S., 1967, Addiction liability of albino rats: breeding for quantative differences in morphine drinking. Science 157: 561.Google Scholar
  28. OLIVERIO, A.& CASTELLANO, C., 1974, Genotype-dependent sensitivity and tolerance to morphine and heroine: dissociation between opiate-induced running and analgesia in the mouse. Psychopharmacologia 39: 13.Google Scholar
  29. OLIVERIO, A., CASTELLANO, C.,& ELEFTHERIOU, B. E., 1974, Morphine sensitivity and tolerance: a genetic investigation in the mouse. Psychopharmacologia, in press.Google Scholar
  30. PERT, C. B.& SNYDER, S. H., 1973, Opiate receptor: demonstration in nervous tissue. Science 179: 1011.Google Scholar
  31. SANTOS, C. H., III, MIDAUGH, L., BUCKHOLTZ, N.& ZEMP, J. W., 1973, Effects of methadone on activity and on brain monoamines in two mouse strains. Fed. Proc. 32: 758.Google Scholar
  32. SCHLESINGER, K., BOGGAN, W. O.& FREEDMAN, D. X., 1965, Genetics of audiogenic seizures: I. Relation to brain serotonin and norepinephrine in mice. Life Sci. 4: 2345.Google Scholar
  33. SHUSTER, L., HANNAM, R. V.& BOYLE, W. E., JR., 1963, A simple method for producing tolerance to dihydro-morphinone in mice.J Pharmacol. Exe. Ther. 140: 149.Google Scholar
  34. SHUSTER, L., WEBSTER, G. W.& YU, G., 1974a, Increased running response to morphine in morphine-pretreated mice. J. Pharmacol. Exp. Ther., in press.Google Scholar
  35. SHUSTER, L., WEBSTER, G. W.& YU, G., 1974b, Perinatal narcotic addiction in mice: sensitization to morphine stimulation. Internat. J. of Addictive Diseases, in press.Google Scholar
  36. SHUSTER, L., WEBSTER, G. W., YU, G.& ELEFTHERIOU, B. E., 1974c, A genetic analysis of the response to morphine in mice analgesia and running. Psychopharmacologia, in press.Google Scholar
  37. SUDAK, H. S.& MAAS, J. W., 1964, Central nervous system serotonin and norepinephrine localization in emotional and nonemotional strains in mice. Nature 203: 1254.PubMedCrossRefGoogle Scholar
  38. TILSON, H. A.& RECH, R. H., 1974, The effects of p-chlorophenylanine on morphine analgesia, tolerance and dependence development in two strains of rats. Psychopharmacologia 35: 45.Google Scholar
  39. VALZELLI, L., 1973, Psychopharmacology-an introduction to experimental and clinical principles, p. 51 Spectrum Publications, Flushing, New York.Google Scholar
  40. VOGT, M., 1973, Types of neurones involved in the analgesic effect of morphine. In Kosterlitz, H. W., Collier, H. O. J.,& Villarael, J. E. (eds.). Agonist and antagonist actions of narcotic analgesic drugs. University Park Press, Baltimore, p. 139–141.Google Scholar
  41. WAY, E. L., LOH, H. H.& SHEA, F. H., 1969, Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167: 1.Google Scholar
  42. WAY, E. L., HO, I. K.& LOH, H. H., 1973, Relation of brain serotonin to the inhibition and enhancement of morphine tolerance and physical dependence. In A. J. Mandell, (ed). New Concepts in Neurotransmitter Regulation. Plenum Press, N. Y. pp. 279–295.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Louis Shuster
    • 1
  1. 1.Department of Biochemistry and PharmacologyTufts University School of MedicineBostonUSA

Personalised recommendations