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Electroconformational Coupling: A Fundamental Process of Biomolecular Electronics for Signal Transductions

  • Tian Yow Tsong

Summary

Biomolecules are like electronic elements and are built to process information. Proteins of a cell membrane are adept to receive and to decipher even the very weak electromagnetic signals. Experiments on ion channel activity and on electric activation of [Na, K] -ATPase and mitochondrial ATPase reveal a fundamental process of the biomolecular electronics, the “Resonance Electroconformational Coupling”. An alternating electric field of a defined amplitude and frequency is shown to induce oscillation of protein conformers. The process can turn the activity of the protein on and off much like a molecular switch. When coupled to ligand binding it also allows the molecule to use the binding energy of a ligand to drive an endergonic reaction.

Keywords

Pulse Electric Field Transmembrane Potential Mitochondrial ATPase Conformational Coupling Oriented Dipole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Tian Yow Tsong
    • 1
  1. 1.Department of BiochemistryUniversity of Minnesota College of Biological SciencesSt. PaulUSA

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