Regional Diastolic Dysfunction in Coronary Artery Disease: Clinical and Therapeutic Implications

  • Hubert Pouleur
  • Michel F. Rousseau


Alterations in left ventricular diastolic function, such as reduction in the rate of pressure-decrease during isovolumic relaxation, impaired rate of rapid filling, or upward shift of the diastolic pressure-volume relation, are found in most patients with coronary artery disease [1–9]. These abnormalities are particularly severe during angina [2, 8], but they are also frequently evident in the absence of clinical signs of ischemia [3–6, 9, 10]. It has also been shown that these altered diastolic properties may be improved by several therapeutic interventions [6, 9–11].


Diastolic Function Exercise Duration Left Ventricular Diastolic Function Peak Filling Rate Myocardial Relaxation 
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© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • Hubert Pouleur
  • Michel F. Rousseau

There are no affiliations available

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